Michael Laffin
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View article: 75 Implementation of a family physician-staffed streamlined care team at an academic tertiary care children’s hospital
75 Implementation of a family physician-staffed streamlined care team at an academic tertiary care children’s hospital Open
Background CHEO is an academic tertiary care children’s hospital in Ottawa, Ontario that serves a catchment of 500,000 children and youth in eastern Ontario, western Quebec and Nunavut resulting in ∼3000 annual admissions to our general pa…
View article: Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways
Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways Open
Bariatric surgery induces significant microbial and metabolomic changes, however, links between microbial and metabolic pathways have not been fully elucidated. The objective of this study was to conduct a comprehensive investigation of th…
View article: Ileal microbial shifts after Roux-en-Y gastric bypass orchestrate changes in glucose metabolism through modulation of bile acids and L-cell adaptation
Ileal microbial shifts after Roux-en-Y gastric bypass orchestrate changes in glucose metabolism through modulation of bile acids and L-cell adaptation Open
Roux-en-Y gastric bypass (RYGB)-induced glycemic improvement is associated with increases in glucagon-like-peptide-1 (GLP-1) secreted from ileal L-cells. We analyzed changes in ileal bile acids and ileal microbial composition in diet-induc…
View article: Timing of Tributyrin Supplementation Differentially Modulates Gastrointestinal Inflammation and Gut Microbial Recolonization Following Murine Ileocecal Resection
Timing of Tributyrin Supplementation Differentially Modulates Gastrointestinal Inflammation and Gut Microbial Recolonization Following Murine Ileocecal Resection Open
Background: Gastrointestinal surgery imparts dramatic and lasting imbalances, or dysbiosis, to the composition of finely tuned microbial ecosystems. The aim of the present study was to use a mouse ileocecal resection (ICR) model to determi…
View article: The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work
The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work Open
Background Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence is not well defined. Methods A literature search was conducted where inclusion required an assessment, by ge…
View article: A high-sugar diet rapidly enhances susceptibility to colitis via depletion of luminal short-chain fatty acids in mice
A high-sugar diet rapidly enhances susceptibility to colitis via depletion of luminal short-chain fatty acids in mice Open
Western-style diets have been implicated in triggering inflammatory bowel disease activity. The aim of this study was to identify the effect of a short-term diet high in sugar on susceptibility to colitis. Adult wild-type mice were placed …
View article: The success of fecal microbial transplantation in <i>Clostridium difficile</i> infection correlates with bacteriophage relative abundance in the donor: a retrospective cohort study
The success of fecal microbial transplantation in <i>Clostridium difficile</i> infection correlates with bacteriophage relative abundance in the donor: a retrospective cohort study Open
Background: Fecal microbial transplantation (FMT) is used in the treatment of relapsing Clostridium difficile infection (rCDI). Failure rate for FMT is as high as 10% but the mechanisms contributing to a failed FMT are not understood. We u…
View article: A77 CONSUMPTION OF REFINED SUGAR RAPIDLY DECREASES MICROBIAL DIVERSITY AND ENHANCES SYSTEMIC RESPONSE TO MICROBIAL STIMULI
A77 CONSUMPTION OF REFINED SUGAR RAPIDLY DECREASES MICROBIAL DIVERSITY AND ENHANCES SYSTEMIC RESPONSE TO MICROBIAL STIMULI Open
BACKGROUND: Population-based studies have demonstrated an association between refined sugar intake and increased incidence of inflammatory bowel disease. We have previously shown that both long- and short-term exposure to a high sugar diet…
View article: Organ Dysfunction After Surgery in Patients Treated With Individualized or Standard Blood Pressure Management
Organ Dysfunction After Surgery in Patients Treated With Individualized or Standard Blood Pressure Management Open
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JA…
View article: A83 THE MUCOSA-ASSOCIATED-MICROBIOTA IS ASSOCIATED WITH RELAPSE IN CROHN’S DISEASE PATIENTS UNDERGOING ILEOCECAL RESECTION
A83 THE MUCOSA-ASSOCIATED-MICROBIOTA IS ASSOCIATED WITH RELAPSE IN CROHN’S DISEASE PATIENTS UNDERGOING ILEOCECAL RESECTION Open
BACKGROUND: A large proportion of Crohn’s disease patients require an intestinal resection at some point. The most common type of intestinal resection in CD patients is an ileocolonic resection (ICR). Unfortunately, following ICR, disease …
View article: A82 A BACH2 GENE VARIANT IS ASSOCIATED WITH POST-OPERATIVE RECURRENCE OF CROHN’S DISEASE
A82 A BACH2 GENE VARIANT IS ASSOCIATED WITH POST-OPERATIVE RECURRENCE OF CROHN’S DISEASE Open
BACKGROUND: Crohn’s disease often requires intestinal resection, which is not considered curative. Repeat surgical intervention is necessary in over half of the patients following their initial operation. Although many genetic loci are imp…
View article: Factors associated with the post-operative recurrence of Crohn's disease
Factors associated with the post-operative recurrence of Crohn's disease Open
Background- Crohn's disease (CD) is a type of inflammatory bowel disease that can cause inflammation throughout the alimentary tract. Many individuals diagnosed with CD ultimately require intestinal resection. Unfortunately, disease often …
View article: Prebiotic Supplementation Following Ileocecal Resection in a Murine Model is Associated With a Loss of Microbial Diversity and Increased Inflammation
Prebiotic Supplementation Following Ileocecal Resection in a Murine Model is Associated With a Loss of Microbial Diversity and Increased Inflammation Open
Background Individuals with Crohn’s disease frequently require ileocecal resection (ICR), and inflammation often recurs in the neoterminal ileum following surgery. Fructooligosaccharide (FOS) is a fermentable prebiotic that stimulates the …
View article: Ileocolic resection is associated with increased susceptibility to injury in a murine model of colitis
Ileocolic resection is associated with increased susceptibility to injury in a murine model of colitis Open
Ileocolic resection (ICR) is the most common intestinal resection performed for Crohn's disease, with recurrences commonly occurring at the site of the anastomosis. This study used an animal model of ICR in wild-type mice to examine immuno…
View article: Fecal microbial transplantation as a therapeutic option in patients colonized with antibiotic resistant organisms
Fecal microbial transplantation as a therapeutic option in patients colonized with antibiotic resistant organisms Open
Despite increasing interest in fecal microbiota transplantation (FMT), its full therapeutic potential has yet to be determined. Since its increase in popularity, FMT has been shown to be highly effective in the treatment of both Clostridiu…
2015 Canadian Surgery Forum02 The usefulness and costs of routine contrast studies after laparoscopic sleeve gastrectomy for detecting staple line leaks03 The association of change in body mass index and health-related quality of life in severely obese patients04 Inpatient cost of bariatric surgery within a regionalized centre of excellence system05 Regional variations in the public delivery of bariatric surgery: an evaluation of the centre of excellence model06 The effect of distance on short-term outcomes after bariatric surgery07 The role of preoperative upper endoscopy in bariatric surgery: a systematic review08 Outcomes of a dedicated bariatric revision surgery clinic10 Quality of follow-up: a systematic review of the research in bariatric surgery14 Bariatric surgery improves weight loss and cardiovascular disease compared with medical management alone: an Alberta multi-institutional early outcomes study16 Diabetic control after laparoscopic gastric bypass and sleeve gastrectomy: a short-term prospective study17 Knowledge and perception of bariatric surgery among primary care physicians: a survey of family doctors in Ontario19 Is early discharge of patients post laparoscopic sleeve gastrectomy safe?22 A comparison of outcomes between bariatric centres of excellence within Ontario02 Closure methods for laparotomy incisions: a cochrane review03 Closing the audit cycle: Are we consenting correctly now?05 Regional variation in the use of surgery in Ontario06 Quitting general surgery residency: attitudes and factors in Canada07 Nipple-sparing mastectomy: utility of intraoperative frozen section analysis of retroareolar tissue08 Withdrawn09 Reliable assessment of operative performance10 Video assessment as a method of assessing surgical competence: the difference in video-rating skills after 4 years of residency11 Burnout among academic surgeons13 Increased health services use by severely obese patients undergoing emergency surgery: a retrospective cohort study14 Novel models for advanced laparoscopic suturing: taking it to the next level16 Pectoral nerve block in breast and axillary surgery17 Predictors for positive resection margins in gastric adenocarcinoma: a population-based analysis18 Predictors of malignancy in thyroid nodules19 Safety and efficacy of POEM for treatment of achalasia: a systematic review of the literature20 Informed consent for surgery21 Meconium ileus: 20 years of experience22 Paraesophageal hernia repair in the elderly: outcomes in a 10-year retrospective study23 The changing face of breast cancer: younger age and aggressive disease in Filipino Canadians24 A systematic review of intraoperative blood loss estimation methods for major noncardiac surgery: a 50-year perspective25 The AVATAR trial: applying vacuum to accomplish reduced wound infections in laparoscopic pediatric surgery27 Indications for use of damage control surgery in civilian trauma patients: a content analysis and expert appropriateness rating study28 Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients: a content analysis and expert appropriateness rating study29 The impact of health care contact and invasive procedures on <i>Staphylococcus aureus</i> bacteremia: a 5-year retrospective cohort study30 Acute care surgery — positive impact on gallstone pancreatitis31 Safety and efficacy of a step-up approach to management of severe, refractory <i>Clostridium difficile</i> infection32 Clinical and operative outcome of patients with acute cholecystitis who are treated initially with image-guided cholecystostomy34 Assessment of preoperative carbohydrate loading and blood glucose concentration in patients with diabetes35 Impact of pre-emptive lidocaine infiltration at trocar sites (PLITS) and intraoperative ketorolac administration on postoperative pain and narcotics consumption after endocholecystectomy: a randomized-controlled trial36 Expert intraoperative judgment and decision-making: defining the cognitive competencies for safe laparoscopic cholecystectomy37 Teaching clinical anatomy to postgraduate surgical trainees38 Investigating the role of TNFR1 in gastric adenocarcinoma peritoneal metastasis39 Selective outcome reporting and publication biases in surgical randomized controlled trials40 Definitive percutaneous management of symptomatic cholelithiasis41 Peer-based coaching: an innovative method to teach faculty an advanced laparoscopic technique42 Improving teaching and learning in the operating room: Does the surgical procedure feedback rubric support learning?43 Withdrawn44 Mislabelling study designs as case–control in surgical literature45 Measured resting energy expenditure in patients with open abdomens: preliminary data of a prospective pilot study46 Open abdomen management and primary abdominal closure in a surgical abdominal sepsis cohort: a retrospective review47 The effect of early mobilization protocols on postoperative outcomes following abdomina Open
The Canadian Surgery Forum Steering Committee acknowledges and thanks the following organizations for their support of the 2015 Forum: # 02 The usefulness and costs of routine contrast studies after laparoscopic sleeve gastrectomy for dete…