Ryan M. Kramer
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View article: Topological Hierarchical Decompositions
Topological Hierarchical Decompositions Open
Topological data analysis is an emerging field that applies the study of topological invariants to data. Perhaps the simplest of these invariants is the number of connected components or clusters. In this work, we explore a topological fra…
View article: Lyophilization process engineering and thermostability of ID93 + GLA-SE, a single-vial adjuvanted subunit tuberculosis vaccine candidate for use in clinical studies
Lyophilization process engineering and thermostability of ID93 + GLA-SE, a single-vial adjuvanted subunit tuberculosis vaccine candidate for use in clinical studies Open
Promising clinical efficacy results have generated considerable enthusiasm for the potential impact of adjuvant-containing subunit tuberculosis vaccines. The development of a thermostable tuberculosis vaccine formulation could have signifi…
View article: A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery
A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery Open
Current RNA vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited by instability of both the RNA and the lipid nanoparticle delivery system, requiring storage at -20°C or -70°C and compromising universal…
View article: Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model
Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model Open
Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in dosage and administration through different routes. Such a dry powder presentation…
View article: A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response
A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response Open
Current RNA vaccines against SARS-CoV-2 are limited by instability of both the RNA and the lipid nanoparticle delivery system, requiring storage at −20°C or −70°C and compromising universally accessible vaccine distribution. This study dem…
View article: HELOC Applicant Risk Performance Evaluation by Topological Hierarchical Decomposition
HELOC Applicant Risk Performance Evaluation by Topological Hierarchical Decomposition Open
Strong regulations in the financial industry mean that any decisions based on machine learning need to be explained. This precludes the use of powerful supervised techniques such as neural networks. In this study we propose a new unsupervi…
View article: Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2 Open
The Gcn5 histone acetyltransferase (HAT) subunit of the SAGA transcriptional coactivator complex catalyzes acetylation of histone H3 and H2B N-terminal tails, posttranslational modifications associated with gene activation. Binding of the …
View article: Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach
Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach Open
These efforts will aid in the development of a platform formulation for use with other similar vaccines.
View article: Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses
Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses Open
The involvement of innate receptors that recognize pathogen- and danger-associated molecular patterns is critical to programming an effective adaptive immune response to vaccination. The synthetic TLR4 agonist glucopyranosyl lipid adjuvant…