R.P. McAndrew
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View article: The crystal structure of Grindelia robusta 7,13-copalyl diphosphate synthase reveals active site features controlling catalytic specificity
The crystal structure of Grindelia robusta 7,13-copalyl diphosphate synthase reveals active site features controlling catalytic specificity Open
View article: Structure and Interactions of HIV-1 gp41 CHR-NHR Reverse Hairpin Constructs Reveal Molecular Determinants of Antiviral Activity
Structure and Interactions of HIV-1 gp41 CHR-NHR Reverse Hairpin Constructs Reveal Molecular Determinants of Antiviral Activity Open
View article: Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases
Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases Open
View article: Structural Basis for Expanded Substrate Specificities of Human Long Chain Acyl-CoA Dehydrogenase and Related Acyl- CoA Dehydrogenases
Structural Basis for Expanded Substrate Specificities of Human Long Chain Acyl-CoA Dehydrogenase and Related Acyl- CoA Dehydrogenases Open
Crystal structures of human long-chain acyl-CoA dehydrogenase (LCAD) and the E291Q mutant, have been determined. These structures suggest that LCAD harbors functions beyond its historically defined role in mitochondrial β-oxidation of long…
View article: Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases Open
Engineered polyketide synthases (PKSs) are promising synthetic biology platforms for the production of chemicals with diverse applications. The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent…
View article: Engineering glycoside hydrolase stability by the introduction of zinc binding
Engineering glycoside hydrolase stability by the introduction of zinc binding Open
The development of robust enzymes, in particular cellulases, is a key step in the success of biological routes to `second-generation' biofuels. The typical sources of the enzymes used to degrade biomass include mesophilic and thermophilic …
View article: Berkeley Screen: a set of 96 solutions for general macromolecular crystallization
Berkeley Screen: a set of 96 solutions for general macromolecular crystallization Open
Using statistical analysis of the Biological Macromolecular Crystallization Database, combined with previous knowledge about crystallization reagents, a crystallization screen called the Berkeley Screen has been created. Correlating crysta…
View article: Reply to Kiser: Dioxygen binding in NOV1 crystal structures
Reply to Kiser: Dioxygen binding in NOV1 crystal structures Open
In PNAS (1) Kiser has expressed some skepticism about the identity of the active-site dioxygen molecule and suggests that the density is better modeled with two water molecules at partial occupancy. In response, we have performed an extend…
View article: Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy
Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy Open
View article: Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase
Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase Open
Significance NOV1 is a stilbene cleavage oxygenase (SCO). SCOs cleave the central double bond of stilbenes, forming two phenolic aldehydes. Many stilbenes, such as resveratrol, are produced by plants as secondary metabolites. They are also…
View article: Author Index
Author Index Open
View article: Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin β-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6
Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin β-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6 Open
View article: Author Index
Author Index Open
View article: Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin
Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin Open