R. Kathryn McHugh
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View article: Brief Report: Effectiveness of two financial incentives on patient follow‐up after brief substance use disorder inpatient treatment
Brief Report: Effectiveness of two financial incentives on patient follow‐up after brief substance use disorder inpatient treatment Open
Background and Objectives Clinical follow‐up data after substance use disorder (SUD) treatment provides important information about treatment effectiveness, yet compliance is a challenge. We compared financial incentives for obtaining foll…
View article: Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats
Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats Open
Opioid dependence is defined by an aversive withdrawal syndrome upon drug cessation that can motivate continued drug-taking, development of opioid use disorder, and precipitate relapse. An understudied but common opioid withdrawal symptom …
View article: Study protocol for a pilot randomised controlled trial of a virtually delivered behavioural intervention (ACTION) for adults with cancer at risk for opioid use disorder
Study protocol for a pilot randomised controlled trial of a virtually delivered behavioural intervention (ACTION) for adults with cancer at risk for opioid use disorder Open
Introduction Opioid therapy is often central to pain management during cancer care. However, opioid exposure and unaddressed psychological suffering jointly amplify opioid use disorder risk. Therefore, we iteratively developed a behavioura…
View article: Implications of the shift to DSM‐5 for alcohol use disorder prevalence estimates in the National Survey on Drug Use and Health
Implications of the shift to DSM‐5 for alcohol use disorder prevalence estimates in the National Survey on Drug Use and Health Open
Background and aims The Substance Abuse and Mental Health Services Administration's annual National Survey on Drug Use and Health (NSDUH) is a commonly used source for estimating trends in alcohol use disorders (AUD) in the United States. …
View article: Protocol for harmonization of randomized trials testing the addition of behavioral therapy to buprenorphine for opioid use disorder
Protocol for harmonization of randomized trials testing the addition of behavioral therapy to buprenorphine for opioid use disorder Open
Results will help to inform clinical and research efforts to optimize the use of behavioral therapies in the treatment of OUD.
View article: Spontaneous oxycodone withdrawal disrupts sleep, circadian, and electrophysiological dynamics in rats
Spontaneous oxycodone withdrawal disrupts sleep, circadian, and electrophysiological dynamics in rats Open
Opioid dependence is defined by an aversive withdrawal syndrome upon drug cessation that can motivate continued drug-taking, development of opioid use disorder, and precipitate relapse. An understudied but common opioid withdrawal symptom …
View article: Examination of the mild, moderate, and severe alcohol use disorder severity indicators using a nationally representative sample.
Examination of the mild, moderate, and severe alcohol use disorder severity indicators using a nationally representative sample. Open
Results partially support the current AUD indicators as AUD severity and co-occurring problems did broadly increase across the indicators. However, the present study also explores several ways to improve these indicators in future AUD form…
View article: Toward a Psychological Model of Chemical Coping with Opioids in Cancer Care
Toward a Psychological Model of Chemical Coping with Opioids in Cancer Care Open
Learning Objectives: After participating in this CME activity, the psychiatrist should be better able to • Outline the risk factors involved with opioid accessibility in patients receiving treatment for cancer. • Identify factors to addres…
View article: Generalized Biomolecular Modeling and Design with RoseTTAFold All-Atom
Generalized Biomolecular Modeling and Design with RoseTTAFold All-Atom Open
Although AlphaFold2 (AF2) and RoseTTAFold (RF) have transformed structural biology by enabling high-accuracy protein structure modeling, they are unable to model covalent modifications or interactions with small molecules and other non-pro…
View article: Clinical and psychosocial outcomes by sex among individuals prescribed buprenorphine‐naloxone (BUP‐NX) or extended‐release naltrexone (XR‐NTX) for opioid use disorder
Clinical and psychosocial outcomes by sex among individuals prescribed buprenorphine‐naloxone (BUP‐NX) or extended‐release naltrexone (XR‐NTX) for opioid use disorder Open
Background and Objectives Limited research has explored sex differences in opioid use disorder medication (MOUD) treatment outcomes. The purpose of this study was to examine MOUD initiation onto buprenorphine‐naloxone (BUP‐NX) versus exten…
View article: Why do we focus on the exception and not the rule? Examining the prevalence of mono‐ versus polysubstance use in the general population
Why do we focus on the exception and not the rule? Examining the prevalence of mono‐ versus polysubstance use in the general population Open
Background and aims Substance use disorders (SUDs) are predominantly studied as drug class specific constructs (e.g. opioid versus alcohol use disorder). Polysubstance use (PSU), or the use of two or more substances from multiple drug clas…
View article: Blueprinting expandable nanomaterials with standardized protein building blocks
Blueprinting expandable nanomaterials with standardized protein building blocks Open
A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assembl…
View article: Prevalence and correlates of the misuse of z-drugs and benzodiazepines in the National Survey on Drug Use and Health
Prevalence and correlates of the misuse of z-drugs and benzodiazepines in the National Survey on Drug Use and Health Open
Background Benzodiazepines and non-benzodiazepine hypnotics (z-drugs) are commonly prescribed for their anxiolytic and hypnotic properties, though they can also be misused. In studies examining the epidemiology of prescription drug misuse,…
View article: An evaluation of cognitive behavioral therapy for substance use disorders: A systematic review and application of the society of clinical psychology criteria for empirically supported treatments.
An evaluation of cognitive behavioral therapy for substance use disorders: A systematic review and application of the society of clinical psychology criteria for empirically supported treatments. Open
Cognitive behavioral therapy (CBT) is a commonly used treatment for substance use disorders (SUDs) but has not been evaluated using the American Psychological Association's "Tolin Criteria" for determining the empirical basis of psychologi…
View article: CASP15 RNA target predictions with RoseTTAFold-NA
CASP15 RNA target predictions with RoseTTAFold-NA Open
Structure predictions of CASP-15 RNA targets made using RoseTTAFold-NA on December 9, 2022.
View article: Defining Prescription Drug Misuse: A Naturalistic Evaluation of National Survey on Drug Use and Health Data From 2012–2014 to 2015–2017
Defining Prescription Drug Misuse: A Naturalistic Evaluation of National Survey on Drug Use and Health Data From 2012–2014 to 2015–2017 Open
Objectives Prescription drug misuse (PDM) is a significant public health problem. As research has evolved, the definitions of misuse have varied over time, yet the implications of this variability have not been systematically studied. The …
View article: An Evaluation of Cognitive Behavioral Therapy for Substance Use Disorder: A Systematic Review and Application of the Society of Clinical Psychology Criteria for Empirically Supported Treatments
An Evaluation of Cognitive Behavioral Therapy for Substance Use Disorder: A Systematic Review and Application of the Society of Clinical Psychology Criteria for Empirically Supported Treatments Open
Cognitive behavioral therapy (CBT) is a commonly used treatment for substance use disorders (SUDs) but has not been evaluated using the American Psychological Association’s “Tolin Criteria” for determining the empirical basis of psychologi…
View article: Accurate prediction of nucleic acid and protein-nucleic acid complexes using RoseTTAFoldNA
Accurate prediction of nucleic acid and protein-nucleic acid complexes using RoseTTAFoldNA Open
Protein-nucleic acid complexes play critical roles in biology. Despite considerable recent advances in protein structure prediction, the prediction of the structures of protein-nucleic acid complexes without homology to known complexes is …
View article: Reducing opioid use disorder and overdose deaths in the United States: A dynamic modeling analysis
Reducing opioid use disorder and overdose deaths in the United States: A dynamic modeling analysis Open
Opioid overdose deaths remain a major public health crisis. We used a system dynamics simulation model of the U.S. opioid-using population age 12 and older to explore the impacts of 11 strategies on the prevalence of opioid use disorder (O…
View article: Operationalizing Engagement With an Interpretation Bias Smartphone App Intervention: Case Series
Operationalizing Engagement With an Interpretation Bias Smartphone App Intervention: Case Series Open
Background Engagement with mental health smartphone apps is an understudied but critical construct to understand in the pursuit of improved efficacy. Objective This study aimed to examine engagement as a multidimensional construct for a no…
View article: The opioid use disorder core outcomes set (OUD–COS) for treatment research: findings from a Delphi consensus study
The opioid use disorder core outcomes set (OUD–COS) for treatment research: findings from a Delphi consensus study Open
Background and Aim There is no gold‐standard and considerable heterogeneity in outcome measures used to evaluate treatments for opioid use disorder (OUD) along the opioid treatment cascade. The aim of this study was to develop the US Natio…
View article: Are Pain and Negative Affect Coping Distinct Motives for Opioid Misuse?
Are Pain and Negative Affect Coping Distinct Motives for Opioid Misuse? Open
Background: Coping with pain is a commonly reported motive for opioid misuse. Opioids also provide relief of stress and negative affect and thus are often misused to cope with these emotional states. Although several studies have investiga…
View article: Clinical utility of a hybrid secondary and relapse prevention program in adults with mild intellectual disability in community residential and day habilitation settings
Clinical utility of a hybrid secondary and relapse prevention program in adults with mild intellectual disability in community residential and day habilitation settings Open
The Refusal Skills Group is developmentally appropriate for people with mild ID in that: (1) they can learn and demonstrate refusal skills and (2) their skill acquisition is predicted more strongly by exposure to the intervention than by i…
View article: Association of State Social and Environmental Factors With Rates of Self-injury Mortality and Suicide in the United States
Association of State Social and Environmental Factors With Rates of Self-injury Mortality and Suicide in the United States Open
These findings suggest that SIM rates were associated with modifiable, upstream factors. Although embedded in SIM, suicide unexpectedly deviated in proposed social and environmental determinants. Heterogeneity in medicolegal death investig…