Ryan Mellor YOU? Author Swipe

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pH-modulated soluble expression of alcohol dehydrogenases in Escherichia coli using adaptive laboratory evolution Open

Suraj Mital, Graham Christie, Annette Alcasabas, Ryan Mellor, Duygu Dikicioǧlu · 2025

Industrial production of alcohol dehydrogenases (ADHs) is severely hampered by their propensity to form insoluble inclusion bodies during recombinant expression. This work achieves soluble expression of such historically aggregate-prone en…

Clustered, SERS-Active, Ultrasmall AuNPs for Photothermal Therapy Open

Ryan Mellor, Guojun Xiong, Alexandra Vaideanu, Benjamin Gardner, Nicholas Stone , et al. · 2025

The results provide proof-of-concept for the potential of these AuNCs in photothermal cancer therapy. Future work should focus on improving tumour targeting, optimizing treatment parameters, and assessing long-term safety to advance this p…

A lipid-based delivery platform for thermo-responsive delivery of teriparatide Open

Corinna Schlosser, Wojciech Rozek, Ryan Mellor, Szymon W. Manka, Christopher J. Morris , et al. · 2024

Teriparatide (and analogue peptides) are the only FDA approved anabolic treatments for osteoporosis. Current therapies are administered as a daily subcutaneous injection, which limits patient adherence and clinical efficacy. To achieve the…

A lipid-based delivery platform for pulsatile delivery of teriparatide Open

Corinna Schlosser, Wojciech Rozek, Ryan Mellor, Szymon W. Manka, Christopher M. Morris , et al. · 2024

The influence of amphiphilic quaternary ammonium palmitoyl glycol chitosan (GCPQ) polymer composition on oil-loaded nanocapsule architecture Open

Francisco Humberto Xavier Júnior, Rui M. Lopes, Ryan Mellor, Ijeoma F. Uchegbu, Andreas G. Schätzlein · 2024

Non-linear mathematical models (Particle size (nm) = 466.05 - 5.64DP - 6.52DQ + 0.13DQ² - 0.03 MW² - 14.48cHLB + 0.48cHLB²) were derived to predict the nanoparticle sizes (R² = 0.998, R²

Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents—A Novel Polymer Formulation for Anticancer Therapy Open

Yvonne Lerchbammer-Kreith, Michaela Hejl, Nadine S. Sommerfeld, Xian Weng-Jiang, Uchechukwu Odunze , et al. · 2023

Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug delivery properties and has been studied as a carrier for anticancer agents. Consequently, we synthesised cytotoxic platinum(IV) conjugates of cisplatin…

Ultrasmall-in-Nano: Why Size Matters Open

Ryan Mellor, Ijeoma F. Uchegbu · 2022

Gold nanoparticles (AuNPs) are continuing to gain popularity in the field of nanotechnology. New methods are continuously being developed to tune the particles’ physicochemical properties, resulting in control over their biological fate an…

Particulate levodopa nose-to-brain delivery targets dopamine to the brain with no plasma exposure Open

Savvas Dimiou, Rui M. Lopes, Ilona Kubajewska, Ryan Mellor, Corinna Schlosser , et al. · 2022

Levodopa (L-DOPA) is an oral Parkinson's Disease drug that generates the active metabolite - dopamine (DA) in vivo. However, oral L-DOPA exhibits low oral bioavailability, limited brain uptake, peripheral DA-mediated side effects and its p…

SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray Open

Krzysztof Pyrć, Aleksandra Milewska, Emilia Barreto-Durán, Paweł Botwina, Agnieszka Dąbrowska , et al. · 2021

Development of Bio-Functionalized, Raman Responsive, and Potentially Excretable Gold Nanoclusters Open

Ryan Mellor, Andreas G. Schätzlein, Ijeoma F. Uchegbu · 2021

Gold nanoparticles (AuNPs) are used experimentally for non-invasive in vivo Raman monitoring because they show a strong absorbance in the phototherapeutic window (650–850 nm), a feature that is accompanied by a particle size in excess of 1…

SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray Open

Ijeoma F. Uchegbu, Krzysztof Pyrć, Aleksandra Milewska, E Duran, Paweł Botwina , et al. · 2020

There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is spread by respiratory droplets …

SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray Open

Krzysztof Pyrć, Aleksandra Milewska, Emilia Barreto-Durán, Paweł Botwina, Rui M. Lopes , et al. · 2020