Ryan Mifflin
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View article: Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice
Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice Open
Deletion of the nuclear hormone receptor small heterodimer partner (Shp) ameliorates the development of obesity and nonalcoholic steatohepatitis (NASH) in mice. Liver-specific SHP plays a significant role in this amelioration. The gut micr…
View article: Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice
Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice Open
Deficiency of the orphan nuclear hormone receptor small heterodimer partner (SHP, NR0B2) protects mice from diet-induced hepatic steatosis, in part, via repression of peroxisome proliferator-activated receptor (PPAR)-γ 2 ( Pparg2) gene exp…