Ryan Mulhern
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View article: L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling
L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling Open
Background: L-2-hydroxyglutarate (L2HG) couples mitochondrial and cytoplasmic energy metabolism to support cellular redox homeostasis. Under oxygen-limiting conditions, mammalian cells generate L2HG to counteract the adverse effects of red…
View article: Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI
Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI Open
Background Ischemic AKI lacks a urinary marker for early diagnosis and an effective therapy. Differential nucleophosmin (NPM) phosphorylation is a potential early marker of ischemic renal cell injury and a therapeutic target. Methods Diffe…
View article: Proteinuria causes dysfunctional autophagy in the proximal tubule
Proteinuria causes dysfunctional autophagy in the proximal tubule Open
Proteinuria is a major risk factor for chronic kidney disease progression. Furthermore, exposure of proximal tubular epithelial cells to excess albumin promotes tubular atrophy and fibrosis, key predictors of progressive organ dysfunction.…