Ryan Neff
YOU?
Author Swipe
View article: Dysfunction of ubiquitin protein ligase <i>MYCBP2</i> leads to cell resilience in human breast cancers
Dysfunction of ubiquitin protein ligase <i>MYCBP2</i> leads to cell resilience in human breast cancers Open
Breast cancer is the most common type of cancer among women worldwide, and it is estimated that 294 000 new diagnoses and 37 000 deaths will occur each year in the United States alone by 2030. Large-scale genomic studies have identified a …
View article: Multi‐omics‐based analysis of high grade serous ovarian cancer subtypes reveals distinct molecular processes linked to patient prognosis
Multi‐omics‐based analysis of high grade serous ovarian cancer subtypes reveals distinct molecular processes linked to patient prognosis Open
Despite advancements in treatment, high‐grade serous ovarian cancer (HGSOC) is still characterized by poor patient outcomes. To understand the molecular heterogeneity of this disease, which underlies the challenge in selecting optimal trea…
View article: Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling
Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling Open
Sensitivity to immune checkpoint blockades (ICB) depends on the overall balance of immunogenic and immunosuppressive signals in the tumor immune microenvironment (TIME). Chemotherapy as an immunostimulatory strategy showed potential in imp…
View article: Whole genome sequencing–based copy number variations reveal novel pathways and targets in Alzheimer's disease
Whole genome sequencing–based copy number variations reveal novel pathways and targets in Alzheimer's disease Open
Introduction A few copy number variations (CNVs) have been reported for Alzheimer's disease (AD). However, there is a lack of a systematic investigation of CNVs in AD based on whole genome sequencing (WGS) data. Methods We used four method…
View article: Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease
Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease Open
Metabolites, the biochemical products of the cellular process, can be used to measure alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease (AD). However, the relationships between systemic abnormalities in…
View article: Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease Open
Communication between glial cells has a profound effect on the pathophysiology of Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. Here, we reveal a role of reactive astrocytes in enforcing cell distancing in the gli…
View article: 14-3-3ζ Captures SET in the Cytoplasm, Mediating Tau Pathology and Cognitive Impairments
14-3-3ζ Captures SET in the Cytoplasm, Mediating Tau Pathology and Cognitive Impairments Open
Background : 14-3-3ζ is overexpressed in brain regions affected by tau pathology in Alzheimer’s disease (AD), and its expression correlates with disease progression. The nuclear protein SET is a specific and efficient endogenous inhibitor …
View article: Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer
Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer Open
Gold nanoparticles (AuNPs) have been shown to enhance cancer radiotherapy (RT) gain by localizing the absorption of radiation energy in the tumor while sparing surrounding normal tissue from radiation toxicity. Previously, we showed that A…
View article: Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets
Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets Open
Three major molecular subtypes of Alzheimer’s disease are identified, cross-validated, and characterized across 1543 individuals.
View article: Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease
Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease Open
SUMMARY To study the molecular mechanisms driving the pathogenesis and identify novel therapeutic targets of late onset Alzheimer’s Disease (LOAD), we performed an integrative network analysis of whole-genome DNA and RNA sequencing profili…
View article: Primary Aldosteronism and<i>ARMC5</i>Variants
Primary Aldosteronism and<i>ARMC5</i>Variants Open
Germline ARMC5 variants may be associated with primary aldosteronism. Additional cohorts of patients with primary aldosteronism and metabolic syndrome, particularly African Americans, should be screened for ARMC5 sequence variants because …