Explanipedia

miRNA-146a protects mice from hepatocellular carcinoma by suppressing age-associated CD8+ T-cells 2715 Open

Morgan C. Nelson, Vu Long Tran, Colton J. Hernandez, Cathal Doherty, Ryan M. O’Connell · 2025

Description Liver cancer is a major cause of cancer-related death globally, with Hepatocellular Carcinoma (HCC) representing up to 90% of primary liver cancers. Our lab and others have shown that the micro-RNA miR-146a protects mice from H…

1137 A human-derived bacterium’s capsular polysaccharide activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy Open

Allison M. Weis, Kaylyn M. Bauer, Neli Ulrich, Ryan M. O’Connell, William W. Tang , et al. · 2025

MicroRNA regulation of messenger RNA vaccine responses in a mouse model of acute myeloid leukemia 3050 Open

William W. Tang, Kaylyn M. Bauer, Soh-Hyun Lee, Liam O’Malley, Colton J. Hernandez , et al. · 2025

Description Acute myeloid leukemia (AML) is the most common adult leukemia and is characterized by aggressive myeloblast proliferation. CAR-T cell and immune checkpoint blockade immunotherapies are in clinical trials for their ability to e…

Macrophage metabolic rewiring rejuvenates muscle Raman signatures and cellular remodeling during regrowth in aged mice Open

Zachary J. Fennel, Negar Kosari, Paul‐Emile Bourrant, Elena M. Yee, Robert Castro , et al. · 2025

Impaired muscle regrowth in aging is underpinned by reduced proinflammatory macrophage function and subsequently impaired muscle cellular remodeling. Macrophage phenotype is metabolically controlled through TCA intermediate accumulation an…

A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy Open

Allison M. Weis, Kaylyn M. Bauer, William W. Tang, Emmanuel Stephen‐Victor, Rickesha Bell , et al. · 2025

microRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma Open

Chad VanSant‐Webb, J.M. Castro, Audrey Y. Su, Kathleen A. Hawkins, Aavrati Saxena , et al. · 2025

Backgrounds and Aims The prevalence of hepatocellular carcinoma (HCC) is rising in parallel with increasing obesity and metabolic dysfunction-associated steatohepatitis (MASH). MicroRNAs are key post-transcriptional regulators of gene expr…

Adolescent to Parent Violence in the Wake of Domestic and Family Violence: Practitioner Insights Open

Amy Young, Jemma Venables, Ryan M. O’Connell, Patrick O’Leary · 2025

TCGEx: a powerful visual interface for exploring and analyzing cancer gene expression data Open

Muhammet Emre Kus, Cagatay Sahin, Emre Kılıç, Arda Askin, Mustafa Mert Özgür , et al. · 2025

Analyzing gene expression data from the Cancer Genome Atlas (TCGA) and similar repositories often requires advanced coding skills, creating a barrier for many researchers. To address this challenge, we developed The Cancer Genome Explorer …

A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy Open

William W. Tang, Ben Battistone, Kaylyn M. Bauer, Allison M. Weis, Cindy Barba , et al. · 2025

The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants…

Macrophage immunometabolism: emerging targets for regrowth in aging muscle Open

Zachary J. Fennel, Ryan M. O’Connell, Micah J. Drummond · 2025

The recovery from muscle atrophy is impaired with aging as characterized by improper muscle remodeling and sustained functional deficits. Age-related deficits in muscle regrowth are tightly linked with the loss of early pro-inflammatory ma…

HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-κB pathway Open

Karen Acuña-Pilarte, Ethan C. Reichert, Yangsook Song Green, Lily M-T. Halberg, Martin Golkowski , et al. · 2024

Background and Aims: HCC incidence is increasing worldwide due to the obesity epidemic, which drives metabolic dysfunction–associated steatohepatitis (MASH) that can lead to HCC. However, the molecular pathways driving MASH-HCC are poorly …

A molecularly-confirmed extraskeletal myxoid chondrosarcoma with dual gene rearrangements, EWSR1::NR4A3 and HAPLN1::EDIL3 fusion Open

Dong Ren, Katherine Wei, Ryan M. O’Connell · 2024

Background: Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal neoplasm with uncertain origin that is commonly seen in the lower extremities. Due to lack of specific clinical presentation, radio-pathologic and immunohistochemi…

A novel visual analysis interface enables integrative analyses of cancer transcriptomics data and iden-tifies potential markers of immunotherapy response via machine learning. Open

Muhammet Emre Kus, Cagatay Sahin, Emre Kılıç, Arda Askin, Mustafa Mert Özgür , et al. · 2023

The Cancer Genome Atlas (TCGA) initiative has been essential for revealing key mechanisms in hu-man cancer leading to the development of novel therapeutics. Analysis of the cancer transcriptomics data in the TCGA and other public repositor…

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia Open

Jian‐Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Meng‐Fang Wu , et al. · 2023

RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered…

Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation Open

Enric Mocholí, Laura Russo, Keshav Gopal, Andrew G. Ramstead, Sophia M. Hochrein , et al. · 2023

miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation Open

Arevik Ghazaryan, Jared Wallace, William W. Tang, Cindy Barba, Soh-Hyun Lee , et al. · 2023

Graphical Abstract We blocked pyruvate entry into mitochondria and decreased Oxidative Phosphorylation (OXPHOS) in human AML cell lines MV4-11 and MOLM-14 by using gene editing tools. This metabolic shift led to increased expression of miR…

T cell expressed microRNA-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1 Open

William W. Tang, H. Atakan Ekiz, Warren P. Voth, Kaylyn M. Bauer, Cindy Barba , et al. · 2023

Colorectal cancer (CRC) is the 2nd deadliest cancer globally and has the 3rd highest incidence and mortality in the United States. Advanced-stage disease is incurable by current clinical standards. Thus, alternative treatments are being ex…

Supplementary Figures and Legends from Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade Open

Jeremy P. Snook, Ashleigh J. Soedel, H. Atakan Ekiz, Ryan M. O’Connell, Matthew A. Williams · 2023

Supp. Fig.1-5 + Legends

Data from Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade Open

Jeremy P. Snook, Ashleigh J. Soedel, H. Atakan Ekiz, Ryan M. O’Connell, Matthew A. Williams · 2023

The presence and activity of CD8⁺ T cells within the tumor microenvironment are essential for the control of tumor growth. Utilizing B16-F10 melanoma tumors that express altered peptide ligands of chicken ovalbumin, OVA_257-…

Supplementary Figures and Legends from Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade Open

Jeremy P. Snook, Ashleigh J. Soedel, H. Atakan Ekiz, Ryan M. O’Connell, Matthew A. Williams · 2023

Supp. Fig.1-5 + Legends

Data from Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade Open

Jeremy P. Snook, Ashleigh J. Soedel, H. Atakan Ekiz, Ryan M. O’Connell, Matthew A. Williams · 2023

The presence and activity of CD8⁺ T cells within the tumor microenvironment are essential for the control of tumor growth. Utilizing B16-F10 melanoma tumors that express altered peptide ligands of chicken ovalbumin, OVA_257-…

Clec12a tempers inflammation while restricting expansion of a colitogenic commensal Open

Tyson R. Chiaro, Kaylyn M. Bauer, Kyla S. Ost, Emmanuel Stephen‐Victor, Morgan C. Nelson , et al. · 2023

SUMMARY Regulation of the microbiota is critical to intestinal health yet the mechanisms employed by innate immunity remain unclear. Here we show that mice deficient in the C-Type-lectin receptor, Clec12a developed severe colitis, which wa…

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs Open

Spencer Arnesen, Jacob T. Polaski, Zannel Blanchard, Kyle S. Osborne, Alana L. Welm , et al. · 2023

Estrogen receptor α (ER) mutations occur in up to 30% of metastatic ER-positive breast cancers. Recent data has shown that ER mutations impact the expression of thousands of genes not typically regulated by wildtype ER. While the majority …

Interferon Gamma-Inducible NAMPT in Melanoma Cells Serves as a Mechanism of Resistance to Enhance Tumor Growth Open

Cindy Barba, H. Atakan Ekiz, William W. Tang, Arevik Ghazaryan, Mason Hansen , et al. · 2023

(1) Background: Immune cells infiltrate the tumor microenvironment and secrete inflammatory cytokines, including interferons (IFNs), to drive antitumor responses and promote tumor clearance. However, recent evidence suggests that sometimes…

MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation Open

Jacob Thompson, Ruozhen Hu, Thomas B. Huffaker, Andrew G. Ramstead, H. Atakan Ekiz , et al. · 2023

The proinflammatory microRNA-155 (miR-155) is highly expressed in the serum and CNS lesions of patients with multiple sclerosis (MS). Global knockout (KO) of miR-155 in mice confers resistance to a mouse model of MS, experimental autoimmun…

Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG Open

Kasey Schalich, Seesandra V. Rajagopala, Suman R. Das, Ryan M. O’Connell, Fang Yan · 2023

Introduction Intestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote the beneficial effects of a commen…

388 Targeted ovarian cancer immunotherapy through engineering of follicle stimulating hormone receptor (FSHR) antibody to engage T cells Open

Devivasha Bordoloi, Pratik Bhojnagarwala, Alfredo Perales‐Puchalt, Abhijeet D. Kulkarni, Xizhou Zhu , et al. · 2022

Background Ovarian cancer is the deadliest gynecologic malignancy, resulting in the highest mortality among cancers of the female reproductive system. The most prevalent subtype of epithelial ovarian cancer (EOC) is high-grade serous cance…

CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis Open

Kaylyn M. Bauer, Morgan C. Nelson, William W. Tang, Tyson R. Chiaro, D. Garrett Brown , et al. · 2022

Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the r…

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs Open

Spencer Arnesen, Jacob T. Polaski, Zannel Blanchard, Kyle S. Osborne, Alana L. Welm , et al. · 2022

Estrogen receptor α (ER) mutations occur in up to 30% of metastatic ER-positive breast cancers. Recent data has shown that ER mutations impact the expression of thousands of genes not typically regulated by wildtype ER. While the majority …

miR-aculous new avenues for cancer immunotherapy Open

William W. Tang, Kaylyn M. Bauer, Cindy Barba, H. Atakan Ekiz, Ryan M. O’Connell · 2022

The rising toll of cancer globally necessitates ingenuity in early detection and therapy. In the last decade, the utilization of immune signatures and immune-based therapies has made significant progress in the clinic; however, clinical st…

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