Ryan Ottwell
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View article: Adherence to CONSORT-PRO Extension Guidelines for Patient-Reported Outcomes in Randomized Controlled Trials Focused on Peripheral Nerve Blocks: A Meta-epidemiological Study
Adherence to CONSORT-PRO Extension Guidelines for Patient-Reported Outcomes in Randomized Controlled Trials Focused on Peripheral Nerve Blocks: A Meta-epidemiological Study Open
Our meta-epidemiological review reveals substantial nonadherence to CONSORT-PRO guidelines in PNB trials. Although PROs are crucial for capturing patient-centered outcomes, they remain under-reported, especially when treated as secondary e…
View article: Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials
Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials Open
Although vemurafenib showed efficacy in metastatic melanoma, off-label use resulted in limited benefit and increased adverse events. Unclear endpoints and underreported adverse events highlight the need for improved clinical trial design.
View article: The Reporting and Methodological Quality of Systematic Reviews Underpinning Clinical Practice Guidelines Focused on the Management of Cutaneous Melanoma: Cross-Sectional Analysis
The Reporting and Methodological Quality of Systematic Reviews Underpinning Clinical Practice Guidelines Focused on the Management of Cutaneous Melanoma: Cross-Sectional Analysis Open
Background Clinical practice guidelines (CPGs) inform evidence-based decision-making in the clinical setting; however, systematic reviews (SRs) that inform these CPGs may vary in terms of reporting and methodological quality, which affects…
View article: Evaluating the underreporting of patient-reported outcomes in carpal tunnel syndrome randomized controlled trials
Evaluating the underreporting of patient-reported outcomes in carpal tunnel syndrome randomized controlled trials Open
Context In recent years, patient-centered healthcare has become a primary concern for researchers and healthcare professionals. When included in randomized controlled trials (RCTs), patient-reported outcome (PRO) measures serve a critical …
View article: Assessment of Spin in the Abstracts of Systematic Reviews and Meta-analyses on Platelet-Rich Plasma Treatment in Orthopaedics: A Cross-sectional Analysis
Assessment of Spin in the Abstracts of Systematic Reviews and Meta-analyses on Platelet-Rich Plasma Treatment in Orthopaedics: A Cross-sectional Analysis Open
Background: Systematic reviews on the use of platelet-rich plasma (PRP) in orthopaedic surgery are abundant in current published literature. However, a beautification of results (referred to as spin) has been noted in abstracts across vari…
View article: Examining the Public’s Most Frequently Asked Questions About Carpal Tunnel Syndrome and Appraising Online Information About Treatment
Examining the Public’s Most Frequently Asked Questions About Carpal Tunnel Syndrome and Appraising Online Information About Treatment Open
Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Patients often search online for health information regarding common musculoskeletal complaints. Thus, the purpose of this study was to use language process…
View article: The Reporting and Methodological Quality of Systematic Reviews Underpinning Clinical Practice Guidelines Focused on the Management of Cutaneous Melanoma: Cross-Sectional Analysis (Preprint)
The Reporting and Methodological Quality of Systematic Reviews Underpinning Clinical Practice Guidelines Focused on the Management of Cutaneous Melanoma: Cross-Sectional Analysis (Preprint) Open
BACKGROUND Clinical practice guidelines (CPGs) inform evidence-based decision-making in the clinical setting; however, systematic reviews (SRs) that inform these CPGs may vary in terms of reporting and methodological quality, which affect…
View article: REPORTING OF PATIENT-REPORTED OUTCOMES IN RCTS FOCUSED ON TINNITUS: A META STUDY
REPORTING OF PATIENT-REPORTED OUTCOMES IN RCTS FOCUSED ON TINNITUS: A META STUDY Open
Background The inclusion of patient-reported outcomes (PROs) in randomized controlled trials (RCTs) supplements outcomes of treatment efficacy with the patient’s perspectives. The aim of this study was to evaluate reporting completeness of…
View article: The presence of spin in systematic reviews focused on diabetic neuropathy: A cross-sectional analysis
The presence of spin in systematic reviews focused on diabetic neuropathy: A cross-sectional analysis Open
Background Spin—the misrepresentation of a study’s actual results—has the potential to alter a clinician’s interpretation of the study’s findings and therefore could affect patient care. Studies have shown spin frequently occurs in abstrac…
View article: Sickle Cell Disease and Quality of Life: An Evaluation of Reporting of Patient-Reported Outcomes in Randomized Controlled Trials
Sickle Cell Disease and Quality of Life: An Evaluation of Reporting of Patient-Reported Outcomes in Randomized Controlled Trials Open
Sickle cell disease significantly impacts one’s quality of life (QOL); thus, randomized controlled trials (RCTs) have integrated patient-reported outcomes (PROs) to assess patients’ health from their perspective. We aim to evaluate the com…
View article: Evaluating the Public's Interest in Testicle Tanning: Observational Study
Evaluating the Public's Interest in Testicle Tanning: Observational Study Open
Background A new and potentially dangerous health trend, testicle tanning, received extensive media attention following a popular television program where a health and fitness influencer touted that testicular tanning increases testosteron…
View article: An Evaluation of Primary Studies Published in Predatory Journals Included in Systematic Reviews From High-Impact Dermatology Journals: Cross-sectional Study
An Evaluation of Primary Studies Published in Predatory Journals Included in Systematic Reviews From High-Impact Dermatology Journals: Cross-sectional Study Open
Background Predatory publishing is a deceptive form of publishing that uses unethical business practices, minimal to no peer review processes, or limited editorial oversight to publish articles. It may be problematic to our highest standar…
View article: Spin within systematic review abstracts on antiplatelet therapies after acute coronary syndrome: a cross-sectional study
Spin within systematic review abstracts on antiplatelet therapies after acute coronary syndrome: a cross-sectional study Open
Objectives Spin is a reporting practice in which study results are misrepresented by overestimating efficacy or underestimating harm. Prevalence of spin varies between clinical specialties, and estimates are based almost entirely on clinic…
View article: Testicle Tanning: Evaluating the Public’s Interest In A Potentially Harmful New Health Trend (Preprint)
Testicle Tanning: Evaluating the Public’s Interest In A Potentially Harmful New Health Trend (Preprint) Open
UNSTRUCTURED Letter to the Editor
View article: Primary Studies Published in Predatory Journals Are Frequently Included in Systematic Reviews Published in High-Impact Dermatology Journals: A Cross-Sectional Study (Preprint)
Primary Studies Published in Predatory Journals Are Frequently Included in Systematic Reviews Published in High-Impact Dermatology Journals: A Cross-Sectional Study (Preprint) Open
UNSTRUCTURED No abstract required for research letter.
View article: Assessing the Presence of Spin in Abstracts of Systematic Reviews and Meta-Analyses on Testicular Cancer Treatment, Screening, and Quality of Life: Cross-Sectional Analysis
Assessing the Presence of Spin in Abstracts of Systematic Reviews and Meta-Analyses on Testicular Cancer Treatment, Screening, and Quality of Life: Cross-Sectional Analysis Open
Introduction Spin — reporting in a way that exaggerates benefits or minimizes harm — has been shown to affect a clinician’s perceptions of treatment efficacy. It is necessary to identify if spin is used in systematic reviews and meta-analy…
View article: Assessing the United States’ most frequently asked questions about osteopathic medicine, osteopathic education, and osteopathic manipulative treatment
Assessing the United States’ most frequently asked questions about osteopathic medicine, osteopathic education, and osteopathic manipulative treatment Open
Context Osteopathic medicine in the United States continues to produce a substantial number of physicians and medical educators. However, recently popularized misconceptions about osteopathic medical practice, education, and manual therapy…
View article: Spin in Abstracts of Systematic Reviews and Meta-analyses of Melanoma Therapies: Cross-sectional Analysis
Spin in Abstracts of Systematic Reviews and Meta-analyses of Melanoma Therapies: Cross-sectional Analysis Open
Background Spin is defined as the misrepresentation of a study’s results, which may lead to misperceptions or misinterpretation of the findings. Spin has previously been found in randomized controlled trials and systematic reviews of acne …
View article: Evaluating reporting of patient-reported outcomes in peptic ulcer disease: a meta-epidemiological study of randomized controlled trials
Evaluating reporting of patient-reported outcomes in peptic ulcer disease: a meta-epidemiological study of randomized controlled trials Open
Peptic ulcer disease (PUD) can significantly affect quality of life (QoL). These QoL outcomes are often patient-reported, and their inclusion in clinical trials supplements efficacy outcomes to provide the patients’ perspective. This asses…
View article: Spin in Abstracts of Systematic Reviews and Meta-analyses of Melanoma Therapies: Cross-sectional Analysis (Preprint)
Spin in Abstracts of Systematic Reviews and Meta-analyses of Melanoma Therapies: Cross-sectional Analysis (Preprint) Open
BACKGROUND Spin is defined as the misrepresentation of a study’s results, which may lead to misperceptions or misinterpretation of the findings. Spin has previously been found in randomized controlled trials and systematic reviews of acne…
View article: The use of person-first language in scientific literature focused on drug-seeking behavior: a cross-sectional analysis
The use of person-first language in scientific literature focused on drug-seeking behavior: a cross-sectional analysis Open
Context Person first language (PFL) – a way of referring to individuals with medical conditions or disability that emphasizes the person over their condition or disability – is important in reducing the stigma surrounding individuals who e…
View article: Examining the Public’s Most Frequently Asked Questions Regarding COVID-19 Vaccines Using Search Engine Analytics in the United States: Observational Study
Examining the Public’s Most Frequently Asked Questions Regarding COVID-19 Vaccines Using Search Engine Analytics in the United States: Observational Study Open
Background The emergency authorization of COVID-19 vaccines has offered the first means of long-term protection against COVID-19–related illness since the pandemic began. It is important for health care professionals to understand commonly…
View article: Cross-Sectional Analysis of Patient-Centered Language Use in Journals Publishing Research Focused on Heart Failure
Cross-Sectional Analysis of Patient-Centered Language Use in Journals Publishing Research Focused on Heart Failure Open
PURPOSE: Detrimental effects of using non–patient-centered language (nPCL) have been reported for diabetes, mental illness, and obesity, and both the American Medical Association (AMA) and International Committee of Medical Journal Editors…
View article: Correction: The Use of Person-Centered Language in Medical Research Journals Focusing on Psoriasis: Cross-sectional Analysis
Correction: The Use of Person-Centered Language in Medical Research Journals Focusing on Psoriasis: Cross-sectional Analysis Open
[This corrects the article DOI: 10.2196/28415.].
View article: Correction: The Use of Person-Centered Language in Medical Research Journals Focusing on Psoriasis: Cross-sectional Analysis (Preprint)
Correction: The Use of Person-Centered Language in Medical Research Journals Focusing on Psoriasis: Cross-sectional Analysis (Preprint) Open
UNSTRUCTURED REMOVE
View article: Spin in the abstracts of systematic reviews and metaanalyses focused on percutaneous coronary intervention
Spin in the abstracts of systematic reviews and metaanalyses focused on percutaneous coronary intervention Open
Context “Spin” is a form of bias that involves highlighting study results in a way that presents the conclusions about benefit or efficacy beyond the scope of the data. Spin in the abstract of published studies has the potential to affect …
View article: The Use of Person-Centered Language in Medical Research Journals Focusing on Psoriasis: Cross-sectional Analysis
The Use of Person-Centered Language in Medical Research Journals Focusing on Psoriasis: Cross-sectional Analysis Open
Background Person-centered language places a person’s identity before any disability or medical condition they may have. Using person-centered language reduces stigma and improves the patient-physician relationship, potentially optimizing …
View article: Evaluation of spin in the abstracts of systematic reviews and meta-analyses of treatments and interventions for smoking cessation
Evaluation of spin in the abstracts of systematic reviews and meta-analyses of treatments and interventions for smoking cessation Open
Of the reviewed abstracts in systematic reviews and meta-analyses, 96.5% of those that focused on smoking cessation were free of spin. However, the existence of spin warrants further steps to improve the scientific accuracy of abstracts on…