Ryan P. Berger
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View article: Neutrophil prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal <i>Salmonella enterica</i> serovars
Neutrophil prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal <i>Salmonella enterica</i> serovars Open
Nontyphoidal strains of Salmonella enterica are a major cause of foodborne illnesses, and infection with these bacteria results in inflammatory gastroenteritis. Polymorphonuclear leukocytes (PMNs), also known as neutrophils, are a dominant…
View article: Brain structure and allelic associations in Alzheimer's disease
Brain structure and allelic associations in Alzheimer's disease Open
Background Alzheimer's disease (AD), the most prevalent form of dementia, affects 6.5 million Americans and over 50 million people globally. Clinical, genetic, and phenotypic studies of dementia provide some insights of the observed progre…
View article: Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection
Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection Open
Infection of the human gut by Salmonella enterica Typhimurium (STM) results in a localized inflammatory disease that is not mimicked in murine infections. To determine mechanisms by which neutrophils, as early responders to bacterial chall…
View article: Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal<i>Salmonella enterica</i>serovars
Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal<i>Salmonella enterica</i>serovars Open
Nontyphoidal strains of Salmonella enterica are a major cause of foodborne illnesses and infection with these bacteria result in inflammatory gastroenteritis. Neutrophils are a dominant immune cell type found at the site of infection in Sa…
View article: Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during <i>Salmonella</i> infection
Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during <i>Salmonella</i> infection Open
Infection of the human gut by Salmonella enterica Typhimurium (STM) results in a localized inflammatory disease that is not mimicked in murine infections. To determine mechanisms by which neutrophils, as early responders to bacterial chall…
View article: Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids
Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids Open
Salmonella enterica represents over 2500 serovars associated with a wide-ranging spectrum of disease; from self-limiting gastroenteritis to invasive infections caused by non-typhoidal serovars (NTS) and typhoidal serovars, respectively. Ho…
View article: Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System
Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System Open
Salmonella enterica serovar Typhimurium ( S . Typhimurium) causes a significant health burden worldwide, yet host responses to initial stages of intestinal infection remain poorly understood.
View article: Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal<i>Salmonella</i>serovars in human intestinal organoids
Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal<i>Salmonella</i>serovars in human intestinal organoids Open
Salmonella enterica represents over 2500 serovars associated with a wide-ranging spectrum of disease; from self-limiting gastroenteritis to invasive infection caused by non-typhoidal serovars (NTS) and typhoidal serovars, respectively. Hos…
View article: Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system
Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system Open
The intestinal epithelium is a primary interface for engagement of the host response by foodborne pathogens, like Salmonella enterica serovar Typhimurium (STm). While interaction of STm with the mammalian host has been well studied in vitr…
View article: Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape
Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape Open
Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have been reported in humans. One limitation…
View article: Glycosylation and stem cells: Regulatory roles and application of iPSCs in the study of glycosylation‐related disorders
Glycosylation and stem cells: Regulatory roles and application of iPSCs in the study of glycosylation‐related disorders Open
Glycosylation refers to the co‐ and post‐translational modification of protein and lipids by monosaccharides or oligosaccharide chains. The surface of mammalian cells is decorated by a heterogeneous and highly complex array of protein and …
View article: ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells
ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells Open
Polysialic acid (PSA) is a carbohydrate polymer of repeating α-2,8 sialic acid residues that decorates multiple targets, including neural cell adhesion molecule (NCAM). PST and STX encode the two enzymes responsible for PSA modification of…