Ryan Calhoun
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View article: The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation
The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation Open
The transcription factor CUX1 regulates adipocyte differentiation in opposite directions in humans and mice, emphasizing the need for species-specific models in metabolic disease research.
View article: PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition Open
Vascular smooth muscle cells (SMCs) undergo phenotype switching to acquire various fates in response to pathological stimuli. Among these, ‘synthetic’ SMCs—defined by migration, proliferation and extracellular matrix production—accumulate …
View article: PRDM16 controls smooth muscle cell fate in atherosclerosis
PRDM16 controls smooth muscle cell fate in atherosclerosis Open
Summary Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to pathologic stimuli 1–3 . In atherosclerosis, these phenotypically modulated …
View article: Transcriptional regulation of adipocyte lipolysis by IRF2BP2
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 Open
Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by posttranslational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate li…
View article: Transcriptional regulation of adipocyte lipolysis by IRF2BP2
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 Open
Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by post-translational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate l…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism
Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism Open
Collectively, these data demonstrate that blockade of ActRII signaling improves body composition and metabolic parameters during calorie deficit driven by GLP-1 receptor agonism and demonstrate the existence of Akt-independent pathways sup…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…