Ryan Patwell
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View article: Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex
Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex Open
The hypothalamic neuropeptide oxytocin is best known for its prosocial behavioral effects. However, the precise anatomical and cellular targets for oxytocin in the cortex during social behavior remain elusive. Here we show that oxytocin ne…
Rv0100: An essential acyl carrier protein from M. tuberculosis important in dormancy Open
We have identified an acyl-carrier protein, Rv0100, that is up-regulated in a dormancy model. This protein plays a critical role in the fatty acid biosynthesis pathway, which is important for energy storage and cell wall synthesis in Mycob…
A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray Open
The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel subset of OT neurons whose projections preferentially terminate on OT receptor (OTR)-expressing …
Calcium imaging and BAPTA loading of amygdala astrocytes in mouse brain slices Open
Astrocytes are glial cells that exhibit calcium signaling-mediated activity. Here, we present a protocol to monitor and manipulate astrocyte calcium activity from mouse amygdala slices. In the first part of this protocol, we describe the p…
Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up‐regulation of<i>Fmr1</i>gene expression in rat cerebellum Open
Background Alcohol intoxication produces ataxia by affecting the cerebellum, which coordinates movements. Fragile X mental retardation (FMR) protein is a complex regulator of RNA and synaptic plasticity implicated in fragile X‐associated t…
Rv0100, a proposed acyl carrier protein in <i>Mycobacterium tuberculosis</i>: expression, purification and crystallization. Corrigendum Open
The true identity of the protein found in the crystals reported by Bondoc et al. [(2019), Acta Cryst. F 75 , 646–651] is given.
Rv0100, a proposed acyl carrier protein in <i>Mycobacterium tuberculosis</i>: expression, purification and crystallization Open
Acyl carrier proteins (ACPs) are important components in fatty-acid biosynthesis in prokaryotes. Rv0100 is predicted to be an essential ACP in Mycobacterium tuberculosis , the pathogen that is the causative agent of tuberculosis, and there…