Patrick Ryan Potts
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View article: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases Open
Histone acetylation is a critical modification that regulates gene expression by modulating chromatin structure and function. Histone acetyltransferases are essential for maintaining acetylation homeostasis, and the disruption of this bala…
View article: LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation Open
Proximity-inducing modalities that co-opt cellular pathways offer new opportunities to regulate oncogenic drivers. Inspired by the success of proximity-based chimeras in both intracellular and extracellular target space, here we describe t…
View article: Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors
Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors Open
Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB (G3 MB) subtype accounts for about 25% of MB and is associated with the worst outcomes. Herein, we report that more than half of G3 MB tumors express melanoma an…
View article: Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq Open
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue degraders (MGD) are monovalent small molec…
View article: Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells Open
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated variants of AR that are constitutively activ…
View article: LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation
LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation Open
Proximity-inducing modalities that co-opt cellular pathways offer new opportunities to regulate oncogenic drivers. Inspired by the success of proximity-based chimeras in both intracellular and extracellular target space, here we describe t…
View article: VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation Open
In targeted protein degradation (TPD) a protein of interest is degraded by chemically induced proximity to an E3 ubiquitin ligase. One limitation of using TPD therapeutically is that most E3 ligases have broad tissue expression, which can …
View article: Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors
Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors Open
Background Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB subtype accounts for about 25% of MB diagnoses and is associated with the most unfavorable outcomes. Herein, we report that more than half of group 3 …
View article: Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction
Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction Open
This review surveys molecular glue-induced ternary complexes in the PDB and provides an overview of computational methods that can be utilized to predict them.
View article: Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs Open
Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis‐targeting chimera (PROTAC) approaches, owing to favorable drug‐like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are…
View article: Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis
Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis Open
Despite the potential of the inhibitor of apoptosis proteins (IAPs) to block cytochrome c–dependent caspase activation, the critical function of IAPs in regulating mammalian apoptosis remains unclear. We report that the ability of endogeno…
View article: Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis Open
In sympathetic neurons, unlike most nonneuronal cells, growth factor withdrawal–induced apoptosis requires the development of competence in addition to cytochrome c release to activate caspases. Thus, although most nonneuronal cells die ra…
View article: Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production
Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production Open
Prader-Willi syndrome (PWS) is a developmental disorder caused by loss of maternally imprinted genes on 15q11-q13, including melanoma antigen gene family member L2 (MAGEL2). The clinical phenotypes of PWS suggest impaired hypothalamic neur…
View article: Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase Open
Spatiotemporal control of Wnt/β-catenin signaling is critical for organism development and homeostasis. The poly-(ADP)-ribose polymerase Tankyrase (TNKS1) promotes Wnt/β-catenin signaling through PARylation-mediated degradation of AXIN1, a…
View article: Enhanced stress tolerance through reduction of G3BP and suppression of stress granules
Enhanced stress tolerance through reduction of G3BP and suppression of stress granules Open
SUMMARY Stress granules (SG) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SG act as a protective mechanism to cope with acute stress, but persistent SG have cytotoxic…
View article: MAGE cancer-testis antigens protect the mammalian germline under environmental stress
MAGE cancer-testis antigens protect the mammalian germline under environmental stress Open
Mammals evolved testis-specific Mage-a genes to protect the male germline under starvation stress and are co-opted in cancer.
View article: Correction: γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers
Correction: γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers Open
[This corrects the article DOI: 10.18632/oncotarget.6006.].
View article: Cytosolic iron-sulfur assembly is evolutionarily tuned by a cancer-amplified ubiquitin ligase by Weon et al.
Cytosolic iron-sulfur assembly is evolutionarily tuned by a cancer-amplified ubiquitin ligase by Weon et al. Open
Data for Cytosolic iron-sulfur assembly is evolutionarily tuned by a cancer-amplified ubiquitin ligase by Weon et al.
View article: Cellular and disease functions of the Prader–Willi Syndrome gene<i>MAGEL2</i>
Cellular and disease functions of the Prader–Willi Syndrome gene<i>MAGEL2</i> Open
Melanoma antigen L2 (MAGEL2 or MAGE-L2) is a member of the MAGE family of ubiquitin ligase regulators. It is maternally imprinted and often paternally deleted or mutated in the related neurodevelopmental syndromes, Prader–Willi Syndrome (P…