Ryan S. MacLeod
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View article: Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption
Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption Open
View article: A Ticklish Parrot-dox: Dual Diagnosis of Lyme Carditis and Psittacosis
A Ticklish Parrot-dox: Dual Diagnosis of Lyme Carditis and Psittacosis Open
We present a young female who presented with three weeks of dry cough, dizziness, shortness of breath, headache, and chest pressure. She was found to have atrial flutter, atrial fibrillation and complete heart block, and eventually diagnos…
View article: Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass
Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass Open
View article: Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo Open
The cytokine RANKL is essential for osteoclast formation during physiological and pathological bone resorption. RANKL also contributes to lymphocyte production, development of lymph nodes and mammary glands, as well as other biological act…
View article: Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence Open
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine R…
View article: Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption
Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption Open
View article: Osteoblasts Suppress Bone Resorption Via Production of Osteoprotegerin
Osteoblasts Suppress Bone Resorption Via Production of Osteoprotegerin Open
View article: Effective CRISPR interference of an endogenous gene via a single transgene in mice
Effective CRISPR interference of an endogenous gene via a single transgene in mice Open
Drawbacks of conditional gene deletion in mice include the need for extensive breeding and, often, a lack of cell type-specificity. CRISPR interference (CRISPRi) is an alternative approach for loss-of-function studies that inhibits express…