Ryan Samarakoon
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View article: AHA PREVENT Equations and Cardiovascular Disease Risk in Diverse Health Care Populations
AHA PREVENT Equations and Cardiovascular Disease Risk in Diverse Health Care Populations Open
The PREVENT model moderately discriminated ASCVD incidence across 4 geographically distinct academic health care systems in the United States. However, calibration metrics varied widely across health care systems, sociodemographics, and un…
View article: Individual variability of neural computations in the primate retina
Individual variability of neural computations in the primate retina Open
Variation in the neural code contributes to making each individual unique. We probed neural code variation using ∼100 neural population recordings from major ganglion cell types in the macaque retina, combined with an interpretable computa…
Oligogenic inheritance of a human heart disease involving a genetic modifier Open
Three rights can make a wrong Many diseases are thought to arise from co-inheritance of rare genetic variants that are benign on their own but harmful in combination. This hypothesis has been difficult to validate by functional experiments…
Oligogenic inheritance of congenital heart disease involving a NKX2-5 modifier Open
Complex genetic inheritance is thought to underlie many human diseases, yet experimental proof of this model has been elusive. Here, we show that a human congenital heart defect, left ventricular non-compaction (LVNC), can be caused by a c…