Ryan Seals
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View article: Comparative safety of conjugated estrogens/bazedoxifene versus estrogen/progestin combination hormone therapy among women in the United States: a multidatabase cohort study
Comparative safety of conjugated estrogens/bazedoxifene versus estrogen/progestin combination hormone therapy among women in the United States: a multidatabase cohort study Open
Objective To assess the risk of select safety outcomes including endometrial cancer, endometrial hyperplasia, and breast cancer among women using conjugated estrogens/bazedoxifene (CE/BZA) as compared with estrogen/progestin combination ho…
View article: Bias Amplification in Epidemiologic Analysis of Exposure to Mixtures
Bias Amplification in Epidemiologic Analysis of Exposure to Mixtures Open
Investigators must consider steps to minimize possible bias amplification in the design and analysis of epidemiologic studies of multiple correlated exposures. This may be particularly important when biomarkers of exposure are used. https:…
View article: Journal Club: Depression before and after diagnosis with amyotrophic lateral sclerosis
Journal Club: Depression before and after diagnosis with amyotrophic lateral sclerosis Open
The prevalence of depression among individuals with amyotrophic lateral sclerosis (ALS) is reported to be up to 44%, depending on the assessment methodology.1 Depression negatively affects quality of life in ALS, and psychological stress i…
View article: Cardiovascular disease and diagnosis of amyotrophic lateral sclerosis: A population based study
Cardiovascular disease and diagnosis of amyotrophic lateral sclerosis: A population based study Open
Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurodegenerative disease of unknown etiology. We investigated the association between ALS diagnosis and prior cardiovascular disease (CVD), and CVD-specific, hospital admissions in th…
View article: Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries
Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries Open
Prior studies have suggested that physical trauma might be associated with the development of amyotrophic lateral sclerosis (ALS). We conducted a population-based, individually matched case-control study in Denmark to assess whether hospit…
View article: Risk Factors for Amyotrophic Lateral Sclerosis
Risk Factors for Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive debilitating disease of the upper and lower motor neurons. Median survival of ALS patients is consistently estimated at between 2-3 years from symptom onset, with some evidence that surv…
View article: Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis
Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis Open
In this Danish nationwide study to investigate the association between diabetes and ALS diagnosis, our findings are in agreement with previous reports of a protective association between vascular risk factors and ALS and suggest that type …
View article: Comparison of diagnoses of amyotrophic lateral sclerosis by use of death certificates and hospital discharge data in the Danish population
Comparison of diagnoses of amyotrophic lateral sclerosis by use of death certificates and hospital discharge data in the Danish population Open
Because ALS is rare, large-scale studies are difficult. Hospital and death certificate data are valuable tools, but understanding of how well they capture cases is needed. We identified 3650 incident cases in the Danish National Patient Re…