Ryan T. Botts
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View article: Polluted wetlands contain multidrug-resistance plasmids encoding CTX-M-type extended-spectrum β-lactamases
Polluted wetlands contain multidrug-resistance plasmids encoding CTX-M-type extended-spectrum β-lactamases Open
While most detailed analyses of antibiotic resistance plasmids focus on those found in clinical isolates, less is known about the vast environmental reservoir of mobile genetic elements and the resistance and virulence factors they encode.…
A novel method of screening combinations of angiostatics identifies bevacizumab and temsirolimus as synergistic inhibitors of glioma-induced angiogenesis Open
Tumor angiogenesis is critical for the growth and progression of cancer. As such, angiostasis is a treatment modality for cancer with potential utility for multiple types of cancer and fewer side effects. However, clinical success of angio…
Supra-Versus Submaximal Cycle Ergometer Verification of VO2max in Males and Females Open
This study was designed to determine the optimal intensity for verification phase testing (VP) in healthy, young adults. Thirty one young, active participants (16 females) completed a cycle ergometer graded exercise test (GXT) VO2max test …
Circadian activity patterns of mammalian predators and prey in Costa Rica Open
Temporal niche shifts can shape predator–prey interactions by enabling predator avoidance, enhancing feeding success, and reducing competition among predators. Using a community-based conservation approach, we investigated temporal niche p…
Does Moonlight Increase Predation Risk for Elusive Mammals in Costa Rica? Open
An increasing body of evidence indicates that moonlight influences the nocturnal activity patterns of tropical mammals, both predators and prey. One explanation is that brighter moonlight is associated with increased risk of predation (Pre…
Natural Selection of Melanism in Costa Rican Jaguar and Oncilla: A Test of Gloger’s Rule and the Temporal Segregation Hypothesis Open
The persistence of coat color polymorphisms—such as the coexistence of melanistic and “wild-type” coat color—is an ongoing evolutionary puzzle. We tested the predictions of Gloger’s rule and the Temporal Segregation hypothesis that propose…
Characterization of Four Multidrug Resistance Plasmids Captured from the Sediments of an Urban Coastal Wetland Open
Self-transmissible and mobilizable plasmids contribute to the emergence and spread of multidrug-resistant bacteria by enabling the horizontal transfer of acquired antibiotic resistance. The objective of this study was to capture and charac…