Ryan T. Fansler
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View article: An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut
An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut Open
To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How obligate anaerobic pathogens construct nutrient niches in the densely populated large intestine rema…
View article: Commensal resilience: ancient ecological lessons for the modern microbiota
Commensal resilience: ancient ecological lessons for the modern microbiota Open
The gut microbiota constitutes a complex ecosystem essential for host health, offering metabolic support, modulating the immune system, and protecting against pathogens. However, this community faces constant destabilizing challenges, incl…
View article: Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection Open
View article: Iron acquisition by a commensal bacterium modifies host nutritional immunity during<i>Salmonella</i>infection
Iron acquisition by a commensal bacterium modifies host nutritional immunity during<i>Salmonella</i>infection Open
During intestinal inflammation, host nutritional immunity starves microbes of essential micronutrients such as iron. Pathogens scavenge iron using siderophores, which is counteracted by the host using lipocalin-2, a protein that sequesters…
View article: Respire or expire—precision killing of Helicobacter pylori by targeting complex I respiration
Respire or expire—precision killing of Helicobacter pylori by targeting complex I respiration Open
View article: Mind the Gap: Bridging the Divide from Sequencing Data to Empiric Phenotypes in the Human Gut Microbiota
Mind the Gap: Bridging the Divide from Sequencing Data to Empiric Phenotypes in the Human Gut Microbiota Open
The gut microbiome exerts a powerful influence on human health and disease. Elucidating the underlying mechanisms of the microbiota’s influence is hindered by the immense complexity of the gut microbial community and the glycans they forag…