Ryan T. Wagner
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View article: CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death Open
Transposable elements (TEs) are powerful cis-regulatory drivers of gene expression, particularly during early development when many TEs become de-repressed. MERVL elements are transiently up-regulated in mouse totipotent two-cell (2C) embr…
View article: Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)
Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC) Open
RNA N6-methyladenosine (m6A) plays diverse roles in RNA metabolism and its deregulation contributes to tumor initiation and progression. Clear cell renal cell carcinoma (ccRCC) is characterized by near ubiquitous loss of VHL followed by mu…
View article: CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death Open
Transposable elements (TEs) provide sequences that are powerful cis-regulatory drivers of gene expression programmes. This is particularly apparent during early development when many TEs become de-repressed. MERVL elements are highly yet t…
View article: Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts
Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts Open
Germline variants in the NSD1 gene are responsible for Sotos syndrome, while somatic variants promote neoplastic cell transformation. Our previous studies revealed three alternative RNA isoforms of NSD1 present in fibroblast cell lines (FB…
View article: <scp>SETD2</scp> loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a <scp>TGF</scp>‐β‐independent manner
<span>SETD2</span> loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a <span>TGF</span>‐β‐independent manner Open
Histone‐lysine N ‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is often mutated in clear cell renal cell carcinoma (ccRCC). SETD2 mutation and/or l…
View article: Nucleolar-based <i>Dux</i> repression is essential for embryonic two-cell stage exit
Nucleolar-based <i>Dux</i> repression is essential for embryonic two-cell stage exit Open
Upon fertilization, the mammalian embryo must switch from dependence on maternal transcripts to transcribing its own genome, and in mice this involves the transient up-regulation of MERVL transposons and MERVL-driven genes at the two-cell …
View article: Nucleolar-based <i>Dux</i> repression is essential for 2-cell stage exit
Nucleolar-based <i>Dux</i> repression is essential for 2-cell stage exit Open
Upon fertilisation, the mammalian embryo must switch from dependence on maternal transcripts to transcribing its own genome, and in mice involves the transient upregulation of MERVL transposons and MERVL-driven genes at the 2-cell stage. T…
View article: Additional file 1 of Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer
Additional file 1 of Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer Open
Additional file 1. Table S1: Detailed summary of RRBS QC parameters and patient data from cohort 1, cohort 2, and normal kidney. Table S2: List of differentially methylated CpGs and the gene(s) they are associated with from cohort 1. Table…
View article: The Significant Influencing Factors of Xenophobia
The Significant Influencing Factors of Xenophobia Open
This paper serves as a review of the influencing factors of xenophobia and its behavioral products. Two primary categories of influencing factors of xenophobia are discussed: inherent factors and environmental factors. Inherent factors tha…