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View article: Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug
Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug Open
Suramin was the first effective drug for the treatment of human African sleeping sickness. Structural analogues of the trypanocide have previously been shown to be potent inhibitors of several enzymes. Therefore, four suramin analogues lac…
View article: CCDC 1515963: Experimental Crystal Structure Determination
CCDC 1515963: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Targeting Cartilage Degradation in Osteoarthritis
Targeting Cartilage Degradation in Osteoarthritis Open
Osteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical researc…
View article: Correction to: Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur
Correction to: Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur Open
The original version of this article unfortunately contained a mistake. The PDF version and the online version have discrepancies in the affiliations of the authors. The correct affiliations are given below.
View article: Physiological Studies of <i>Chlorobiaceae</i> Suggest that Bacillithiol Derivatives Are the Most Widespread Thiols in Bacteria
Physiological Studies of <i>Chlorobiaceae</i> Suggest that Bacillithiol Derivatives Are the Most Widespread Thiols in Bacteria Open
Low-molecular-weight thiols are key metabolites that participate in many basic cellular processes: central metabolism, detoxification, and oxidative stress resistance. Here we describe a new thiol, N-methyl-bacillithiol, found in an anaero…
View article: Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur
Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur Open
Purpose of review This article provides a brief overview of natural phytoprotective products of allium with a special focus on the therapeutic potential of diallyl polysulfanes from garlic, their molecular targets and their fate in the liv…
View article: Unusual Nucleophilic Addition of Grignard Reagents in the Synthesis of 4-Amino-pyrimidines
Unusual Nucleophilic Addition of Grignard Reagents in the Synthesis of 4-Amino-pyrimidines Open
Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation of biochemical roles, in particular that of vitamin B1. Herein, we describe a reaction pathway in a Grignard reagent-based syn…
View article: N-methyl-bacillithiol, a new metabolite discovered in the<i>Chlorobiaceae</i>, indicates that bacillithiol and derivatives are widely phylogenetically distributed
N-methyl-bacillithiol, a new metabolite discovered in the<i>Chlorobiaceae</i>, indicates that bacillithiol and derivatives are widely phylogenetically distributed Open
Low-molecular weight (LMW) thiols are metabolites that mediate redox homeostasis and the detoxification of chemical stressors in cells. LMW thiols are also thought to play a central role in sulfur oxidation pathways in phototrophic bacteri…
View article: Think Yellow and Keep Green—Role of Sulfanes from Garlic in Agriculture
Think Yellow and Keep Green—Role of Sulfanes from Garlic in Agriculture Open
Reactive sulfur species from garlic have long been renowned for their health benefits and antimicrobial properties. In agriculture the subject matter is now gathering momentum in the search for new bio-pesticides to addressing emerging env…
View article: The design and synthesis of a novel thiamine cofactor for potential biocatalysis
The design and synthesis of a novel thiamine cofactor for potential biocatalysis Open
The design and application of enzyme mimics has received more attention due to requirement of
\ngreen chemistry applications within industry and academia. One way of introducing these
\nmodifications is via a cofactor, due to their locatio…