Ryan Tuck
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View article: Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283
Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283 Open
Description A goal of an HIV-1 vaccine is induction of broadly neutralizing antibodies (bnAbs) that prevent infection of different strains. Previous studies have shown that infants and children living with HIV-1 generate bnAbs more frequen…
View article: Evidence for Multiple Subpopulations of Herpesvirus-Latently Infected Cells
Evidence for Multiple Subpopulations of Herpesvirus-Latently Infected Cells Open
Latency is the defining characteristic of the Herpesviridae and central to the tumorigenesis phenotype of Kaposi’s sarcoma-associated herpesvirus (KSHV). KSHV-driven primary effusion lymphomas (PEL) rapidly develop resistance to therapy, s…
View article: Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life
Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life Open
Most infant deaths occur in the first year of life. Yet, our knowledge of immune development during this period is scarce and derived from cord blood (CB) only. To more effectively combat pediatric diseases, a deeper understanding of the k…
View article: HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy Open
The majority of new HIV-1 infections occur in young adults, with adolescent women being 3 times more likely to acquire HIV than young men. Implementation of HIV prevention strategies has been less successful in this age group; thus, a vacc…
View article: Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission
Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission Open
Nonhuman primate (NHP) models are invaluable for HIV pathogenesis, intervention and cure studies. To enhance the translational potential of NHP HIV vaccine studies, clinically relevant R5-tropic, tier 2 neutralization sensitive, and mucosa…
View article: Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life
Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life Open
Most infant deaths occur in the first year of life. Yet, our knowledge of immune development during this period is scarce and derived from cord blood (CB) only. To more effectively combat pediatric diseases, a deeper understanding of the k…