Ryan Victor-Joseph
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View article: Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice Open
SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quit…
View article: <i>SIRT5</i>variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology
<i>SIRT5</i>variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology Open
Summary SIRT5 is a sirtuin deacylase that represents the major activity responsible for removal of negatively-charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basa…