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Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts Open
Aging is a major risk factor for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). As metabolic alterations are a hallmark of aging and have previously been observed in ALS, it is important to examine the effect of…
View article: C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis Open
Energy metabolism is altered in amyotrophic lateral sclerosis and its animal models. Using metabolic profiling, Allen et al. reveal a loss of metabolic flexibility in induced astrocytes derived from patients with C9orf72 ALS, caused by def…
View article: Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis Open
As clinical evidence supports a negative impact of dysfunctional energy metabolism on the disease progression in amyotrophic lateral sclerosis, it is vital to understand how the energy metabolic pathways are altered and whether they can be…