Rusung Tan
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View article: A Techno-Economic Assessment of Steam Methane Reforming and Alkaline Water Electrolysis for Hydrogen Production
A Techno-Economic Assessment of Steam Methane Reforming and Alkaline Water Electrolysis for Hydrogen Production Open
This study explores hydrogen’s potential as a sustainable energy source for Brunei, given the nation’s reliance on fossil fuels and associated environmental concerns. Specifically, it evaluates two hydrogen production technologies; steam m…
View article: Viral Infection Detector: Ensemble Learning for Predicting Viral Infection in Single-cell Transcriptomics of Virus-Induced Cancers
Viral Infection Detector: Ensemble Learning for Predicting Viral Infection in Single-cell Transcriptomics of Virus-Induced Cancers Open
Oncoviruses cause around 15-20% of all human cancers. As 3’ end-based single-cell RNA-sequencing (scRNA-seq) methods become more popular, the relationship between viral infection and tumor progression at the transcriptomic level has been i…
View article: Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis
Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis Open
SUMMARY Infective endocarditis (IE) is a life-threatening biofilm-associated infection, yet the factors driving biofilm formation remain poorly understood. Here, we identified the Fsr quorum sensing (QS) system of Enterococcus faecalis as …
View article: Molecular characteristics and antibiotic resistance mechanisms of multidrug-resistant Pseudomonas aeruginosa in Nanning, China
Molecular characteristics and antibiotic resistance mechanisms of multidrug-resistant Pseudomonas aeruginosa in Nanning, China Open
The mechanisms of antibiotic resistance of MDR-PA strains mainly were the production of MBLS and higher expression of MexA in our study, and ST1971 was the predominant ST type of MDR-PA strains in our hospital, our findings may assist in p…
View article: A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes
A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes Open
Summary Objectives We assessed the safety of ustekinumab (a monoclonal antibody used in psoriasis to target the IL-12 and IL-23 pathways) in a small cohort of recent-onset (<100 days of diagnosis) adults with type 1 diabetes (T1D) by co…
View article: Virome-wide serological profiling reveals association of herpesviruses with obesity
Virome-wide serological profiling reveals association of herpesviruses with obesity Open
The relationship between viral infection and obesity has been known for several decades but epidemiological data is limited to only a few viral pathogens. The association between obesity and a wide range of viruses was assessed using VirSc…
View article: Virome-wide serological profiling reveals association of herpesviruses with obesity
Virome-wide serological profiling reveals association of herpesviruses with obesity Open
The relationship between viral infection and obesity has been known for several decades but epidemiological data related to obesity is limited to only a few viral pathogens. To identify associations between viral infections and obesity, a …
View article: BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis
BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis Open
Neonatal administration of BCG vaccine rapidly increases neutrophil production to reduce mortality from sepsis.
View article: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report Open
Background Infections with multidrug-resistant organisms (MDRO) pose a serious threat to patients with dysregulated immunity such as in hemophagocytic lymphohistiocytosis (HLH), but such infections have rarely been comprehensively characte…
View article: A Metagenomics – Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting
A Metagenomics – Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting Open
The etiology of central nervous system (CNS) infections such as meningitis and encephalitis remains unknown in a large proportion of cases partly because the diversity of pathogens that may cause CNS infections greatly outnumber available …
View article: Treg gene signatures predict and measure type 1 diabetes trajectory
Treg gene signatures predict and measure type 1 diabetes trajectory Open
JDRF (1-PNF-2015-113-Q-R, 2-PAR-2015-123-Q-R, 3-SRA-2016-209-Q-R, 3-PDF-2014-217-A-N), the JDRF Canadian Clinical Trials Network, the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (UM1AI109565 a…
View article: A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format
A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format Open
Commercial multiplex assays, built on different chemistries and platforms are widely available for simultaneous detection of pathogens that cause respiratory infections. However, these tests are often difficult to implement in a resource l…
View article: <scp>sPD</scp>‐L1 Expression is Associated with Immunosuppression and Infectious Complications in Patients with Acute Pancreatitis
<span>sPD</span>‐L1 Expression is Associated with Immunosuppression and Infectious Complications in Patients with Acute Pancreatitis Open
Acute pancreatitis ( AP ) with infectious complications has high mortality because of early‐stage immunosuppression. The programmed cell death‐1 ( PD ‐1)/programmed cell death ligand 1 ( PD ‐L1) pathway is an important host immunosuppressi…
View article: Profiling of circulating microRNAs in children with recent onset of type 1 diabetes
Profiling of circulating microRNAs in children with recent onset of type 1 diabetes Open
Type 1 diabetes (T1D) is an autoimmune disease that is clinically silent until the majority of β cells are destroyed. There is an unmet need for reliable and cost-effective biomarkers to predict and diagnose diabetes at an early stage. A n…
View article: T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression
T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression Open
T regulatory cells (Tregs) control immune homeostasis by preventing inappropriate responses to self and nonharmful foreign antigens. Tregs use multiple mechanisms to control immune responses, all of which require these cells to be near the…
View article: Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing
Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing Open
Next-generation sequencing (NGS) technology has shown promise for the detection of human pathogens from clinical samples. However, one of the major obstacles to the use of NGS in diagnostic microbiology is the low ratio of pathogen DNA to …
View article: CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance
CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance Open
Manipulation of regulatory T cell (Treg) migration by islet expression of the chemokine CCL22 prevents diabetes in NOD mice and delays recurrent autoimmunity in syngeneic islet transplants. We sought to determine whether attracting Tregs w…
View article: CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections
CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections Open
Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor and surface markers shared with the natural killer cell lineage. iNKT cells reco…
View article: Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis
Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis Open
C-type lectins are key players in immune regulation by driving distinct functions of antigen-presenting cells. The C-type lectin CLEC16A gene is located at 16p13, a susceptibility locus for several autoimmune diseases, including multiple s…