Ryann Callaghan
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View article: E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis
E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis Open
Balance between microbiota-specific effector and regulatory T (Treg) cells is required to promote intestinal health and limit disease pathology. The pathways regulating T cell equilibrium during inflammation and the role of individual micr…
View article: Gut bacteria–derived serotonin promotes immune tolerance in early life
Gut bacteria–derived serotonin promotes immune tolerance in early life Open
The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remain largely undefined. Here, we demonstrate that the neonatal gut is uniquely enri…
View article: Microbiota regulation of thymic microbiota-specific T cell development
Microbiota regulation of thymic microbiota-specific T cell development Open
While exposure to microbial antigens in peripheral sites causes expansion and differentiation of antigen-specific T cells, a role for antigen-specific expansion had not been identified during T cell development in the thymus. We recently f…
View article: Gut bacteria-derived serotonin promotes immune tolerance in early life
Gut bacteria-derived serotonin promotes immune tolerance in early life Open
The gut microbiome promotes immune system development in early life, but the neonatal gut metabolome remains undefined. Here, we demonstrate that, distinct from adults, the neonatal mouse gut is enriched with neurotransmitters, and specifi…
View article: Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer
Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer Open
Inflammatory bowel disease (IBD) is a chronic life-long inflammatory disease affecting almost 2 million Americans. Although new biologic therapies have been developed, the standard medical treatment fails to selectively control the dysregu…