Ryn Flaherty
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View article: Amygdala microstructural changes in subjective cognitive decline as measured by MRI diffusion kurtosis, neurite orientation dispersion and density, and magnetization transfer imaging
Amygdala microstructural changes in subjective cognitive decline as measured by MRI diffusion kurtosis, neurite orientation dispersion and density, and magnetization transfer imaging Open
Background Our prior work applying diffusion kurtosis imaging (DKI) to subjective cognitive decline (SCD) showed significantly decreased kurtosis fractional anisotropy (KFA) and significantly increased mean kurtosis (MK) for SCD in bilater…
View article: A diffusion kurtosis MRI signature of subjective cognitive decline
A diffusion kurtosis MRI signature of subjective cognitive decline Open
Background Diffusion weighted imaging (DWI) of brain white matter is better at predicting future cognitive decline and medial temporal lobe atrophy than cerebrospinal fluid biomarkers in subjective cognitive decline (SCD)1. However, few st…
View article: A diffusion kurtosis MRI signature of subjective cognitive decline
A diffusion kurtosis MRI signature of subjective cognitive decline Open
Background Diffusion weighted imaging (DWI) of brain white matter is better at predicting future cognitive decline and medial temporal lobe atrophy than cerebrospinal fluid biomarkers in subjective cognitive decline (SCD) 1 . However, few …
View article: Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline
Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline Open
Introduction Alzheimer’s Disease (AD) typically starts in the medial temporal lobe, then develops into a neurodegenerative cascade which spreads to other brain regions. People with subjective cognitive decline (SCD) are more likely to deve…
View article: The impact of subjective cognitive decline on aging effects in the brain as measured by diffusion tensor imaging
The impact of subjective cognitive decline on aging effects in the brain as measured by diffusion tensor imaging Open
Background Diffusion tensor imaging (DTI) can separate subjective cognitive decline (SCD) participants who progress to mild cognitive impairment and those who do not 1. We explored the effect age and memory performance has on DTI measures …
View article: Gray to White Matter Signal Ratio as a novel biomarker of neurodegeneration in Alzheimer’s disease
Gray to White Matter Signal Ratio as a novel biomarker of neurodegeneration in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is characterized neuropathologically by ß‐amyloid (Aß) plaques, hyperphosphorylated tau neurofibrillary tangles, and neurodegeneration which leads to a phenotypically heterogeneous cognitive‐behavioral d…
View article: The impact of subjective cognitive decline on aging effects in the brain as measured by diffusion tensor imaging
The impact of subjective cognitive decline on aging effects in the brain as measured by diffusion tensor imaging Open
Background Diffusion tensor imaging (DTI) can separate subjective cognitive decline (SCD) participants who progress to mild cognitive impairment and those who do not 1 . We explored the effect age and memory performance has on DTI measures…
View article: Distinct Neural Correlates of Anxiety and Depression in Subjective Cognitive Decline versus Healthy Aging, a Microstructural Diffusion MRI Study
Distinct Neural Correlates of Anxiety and Depression in Subjective Cognitive Decline versus Healthy Aging, a Microstructural Diffusion MRI Study Open
Background A common criticism of considering Subjective Cognitive Decline (SCD) as a preclinical stage of Alzheimer’s Disease is that it may be explained by depression or anxiety1. We used NODDI, a diffusion microstructural model2, to expl…
View article: Distinct Neural Correlates of Anxiety and Depression in Subjective Cognitive Decline versus Healthy Aging, a Microstructural Diffusion MRI Study
Distinct Neural Correlates of Anxiety and Depression in Subjective Cognitive Decline versus Healthy Aging, a Microstructural Diffusion MRI Study Open
Background A common criticism of considering Subjective Cognitive Decline (SCD) as a preclinical stage of Alzheimer’s Disease is that it may be explained by depression or anxiety 1 . We used NODDI, a diffusion microstructural model 2 , to …
View article: Gray to white matter signal ratio as a novel biomarker of neurodegeneration in Alzheimer’s disease
Gray to white matter signal ratio as a novel biomarker of neurodegeneration in Alzheimer’s disease Open
Alzheimer's disease (AD) is characterized neuropathologically by β-amyloid (Aβ) plaques, hyperphosphorylated tau neurofibrillary tangles, and neurodegeneration, which lead to a phenotypically heterogeneous cognitive-behavioral dementia syn…
View article: Increased white matter MRI T1 hypointensity volume in young‐onset Alzheimer’s disease patients is not accounted for by age or cardiovascular risk factors
Increased white matter MRI T1 hypointensity volume in young‐onset Alzheimer’s disease patients is not accounted for by age or cardiovascular risk factors Open
Background White matter (WM) hypointensity volume in T1 MRI correlates strongly with T2 hyperintensities and both are typically associated with advancing age and vascular brain injury (VBI). Recent research has suggested that Alzheimer’s D…