Ryo Aoki
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View article: Regioselectivity Inversion in the Cycloaddition Reaction between Stable Nitrile Oxides and Acylalkyne Derivatives
Regioselectivity Inversion in the Cycloaddition Reaction between Stable Nitrile Oxides and Acylalkyne Derivatives Open
1,3-Dipolar cycloaddition reaction of stable nitrile oxides with α,β-alkynyl hydrazones affords 5-iminoisoxazoles, whereas the reaction of nitrile oxides with α,β-alkynyl carbonyl compounds gives 4-acylisoxazoles. The regioselectivity of t…
View article: A Premature Infant With Renal Tubular Dysgenesis Who Survived 61 Days With Anuria
A Premature Infant With Renal Tubular Dysgenesis Who Survived 61 Days With Anuria Open
Autosomal recessive renal tubular dysgenesis (AR-RTD) is a rare and typically lethal disorder of the renin-angiotensin system (RAS), caused by mutations in genes such as angiotensinogen (AGT), renin (REN), angiotensin-converting enzyme (AC…
View article: Regularizing hyperparameters of interacting neural signals in the mouse cortex reflect states of arousal
Regularizing hyperparameters of interacting neural signals in the mouse cortex reflect states of arousal Open
In natural behaviors, multiple neural signals simultaneously drive activation across overlapping brain networks. Due to limitations in the amount of data that can be acquired in common experimental designs, the determination of these inter…
View article: Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish
Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish Open
The cortico-basal ganglia circuit mediates decision making. Here, we generated transgenic tools for adult zebrafish targeting specific subpopulations of the components of this circuit and utilized them to identify evolutionary homologs of …
View article: Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells
Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells Open
Protein kinase C γ (PKCγ), a neuronal isoform present exclusively in the central nervous system, is most abundantly expressed in cerebellar Purkinje cells (PCs). Targeted deletion of PKCγ causes a climbing fiber synapse elimination in deve…
View article: Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization
Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization Open
The production of cell-type- and age-specific genetically modified mice is a powerful approach for unraveling unknown gene functions. Here, we present a simple and timesaving method that enables adeno-associated virus (AAV)-mediated cell-t…
View article: Transgenic tools targeting striatal and pallidal subpopulations revealed evolutionary conservation and specialization of the cortico-basal ganglia circuit in zebrafish
Transgenic tools targeting striatal and pallidal subpopulations revealed evolutionary conservation and specialization of the cortico-basal ganglia circuit in zebrafish Open
Summary The cortico-basal ganglia circuit mediates decision-making. Here, we generated transgenic tools for adult zebrafish targeting specific subpopulations of the components of this circuit and utilized them to identify evolutionary homo…
View article: Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems
Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems Open
Sleep is a crucial component of health, and insomnia is among the most common and vexing of life-habit-related disorders. While dietary sleep-support supplements can improve sleep, choosing an effective dietary supplement can be challengin…
View article: Distributed context-dependent choice information in mouse posterior cortex
Distributed context-dependent choice information in mouse posterior cortex Open
Choice information appears in multi-area brain networks mixed with sensory, motor, and cognitive variables. In the posterior cortex—traditionally implicated in decision computations—the presence, strength, and area specificity of choice si…
View article: Efficient coding of natural images in the mouse visual cortex
Efficient coding of natural images in the mouse visual cortex Open
How communication between neurons gives rise to natural vision remains a matter of intense investigation. The mid-level visual areas along the ventral stream, as studies in primates have shown, are selective to a common class of natural im…
View article: Distributed context-dependent choice information in mouse posterior cortex
Distributed context-dependent choice information in mouse posterior cortex Open
Choice information appears in multi-area brain networks mixed with sensory, motor, and cognitive variables. In the posterior cortex—traditionally implicated in decision computations—the presence, strength, and area specificity of choice si…
View article: Probabilistic discrimination of relative stimulus features in mice
Probabilistic discrimination of relative stimulus features in mice Open
Significance In vision research, oriented gratings are classical stimuli that drive a large population of neurons in the primary visual cortex, but it is unclear whether mice—a recently popular model animal for visual decision-making—can b…
View article: Distributed context-dependent choice information in mouse dorsal-parietal cortex
Distributed context-dependent choice information in mouse dorsal-parietal cortex Open
Choice information appears in the brain as distributed signals with top-down and bottom-up components that together support decision-making computations. In sensory and associative cortical regions, the presence of choice signals, their st…
View article: Distributed context-dependent choice information in mouse dorsal-parietal cortex
Distributed context-dependent choice information in mouse dorsal-parietal cortex Open
Choice information appears in the brain as distributed signals with top-down and bottom-up components that together support decision-making computations. In sensory and associative cortical regions, the presence of choice signals, their st…
View article: Step response of turbulent structure inside a horizontal bubbly channel flow due to sudden change in void fraction
Step response of turbulent structure inside a horizontal bubbly channel flow due to sudden change in void fraction Open
Performance of bubbly drag reduction (BDR) can be improved by repetitive bubble injection (RBI) which provides spatiotemporal fluctuation of local void fraction, termed void waves, to enhance momentum exchange between turbulence and bubble…
View article: Probabilistic discrimination of relative stimulus features in mice
Probabilistic discrimination of relative stimulus features in mice Open
Understanding how the brain computes choice from sensory information is a central question in perceptual decision-making research. From a behavioral perspective, paradigms suitable to study perceptual decision-making condition choice on in…
View article: AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication
AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication Open
Autism susceptibility candidate 2 (AUTS2), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we investiga…
View article: AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication
AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication Open
Summary Autism susceptibility candidate 2 ( AUTS2 ), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we…
View article: Design of bubble splitter for drag reduction of vessels by bubble injection
Design of bubble splitter for drag reduction of vessels by bubble injection Open
Bubble drag reduction (BDR) is expected as a solution to ship energy saving. However, it has a problem that the combination of bubbles at aft disturbs the drag reduction. This study aims to development of bubble splitter to make bubbles fr…
View article: Attention Decorrelates Sensory and Motor Signals in the Mouse Visual Cortex
Attention Decorrelates Sensory and Motor Signals in the Mouse Visual Cortex Open
Summary Visually-guided behaviors depend on the activity of cortical networks receiving visual inputs and transforming these signals to guide appropriate actions. However, non-retinal inputs, carrying motor signals as well as cognitive and…
View article: The precursor osteoblast-like cell, MC3T3-E1 cell line, enhances sodium–calcium exchanger 1 (<i>Ncx1</i>) gene expression by stretch stimuli prior to osteoblast differentiation
The precursor osteoblast-like cell, MC3T3-E1 cell line, enhances sodium–calcium exchanger 1 (<i>Ncx1</i>) gene expression by stretch stimuli prior to osteoblast differentiation Open
This study evaluated the expression of genes involved in the concentration of Ca2+ in precursor osteoblast-like cell, MC3T3-E1 subjected to stretching stimuli. Transient receptor potential vanilloid 4 (Trpv4) gene expression, the factor th…
View article: Interface Shape Optimization for Controlling Natural Frequency of Composite Structure
Interface Shape Optimization for Controlling Natural Frequency of Composite Structure Open
In this paper, a non-parametric shape optimization method is proposed for designing the interface and the outer boundary shapes of a three dimensional composite structure composed of dissimilar materials in natural vibration problem. We em…
View article: An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation
An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation Open
Recording neural activity during animal behavior is a cornerstone of modern brain research. However, integration of cutting-edge technologies for neural circuit analysis with complex behavioral measurements poses a severe experimental bott…
View article: Differential Cellular Control by Cotyledon-Derived Phytohormones Involved in Graft Reunion of Arabidopsis Hypocotyls
Differential Cellular Control by Cotyledon-Derived Phytohormones Involved in Graft Reunion of Arabidopsis Hypocotyls Open
When wounding or grafting interrupts the original connection of plant tissue, cell proliferation is induced and the divided tissue is reunited. Previous studies suggested that gibberellin derived from the cotyledon is required for tissue r…
View article: Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue
Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue Open
Fatigue reduces productivity and is a risk factor for lifestyle diseases and mental disorders. Everyone experiences physiological fatigue and recovers with rest. Pathological fatigue, however, greatly reduces quality of life and requires t…