Ryo Kishida
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View article: Compositionally Optimized Bone Scaffolds Based on Carbonate Apatite and Silver Phosphate for Osteogenesis, Scaffold Resorption, and Photoactivated Antibacterial Activity
Compositionally Optimized Bone Scaffolds Based on Carbonate Apatite and Silver Phosphate for Osteogenesis, Scaffold Resorption, and Photoactivated Antibacterial Activity Open
Antimicrobial resistance (AMR) is a growing global health concern, especially in the management of bone and joint infections. A bioresorbable scaffold comprising carbonate apatite and 0.4 wt % silver phosphate (Ag3PO4) (designated as CASP)…
View article: Wood-Derived Hydrogels for Osteochondral Defect Repair
Wood-Derived Hydrogels for Osteochondral Defect Repair Open
Repairing cartilage tissue is a serious global challenge. Herein, we focus on wood skeletal structures that are highly porous for cell penetration yet have load-bearing strength, and aim to synthesize wood-derived hydrogels with the abilit…
View article: Hematopoietic Function Restoration by Transplanting Bone Marrow Niches In Vivo Engineered Using Carbonate Apatite Honeycomb Bioreactors
Hematopoietic Function Restoration by Transplanting Bone Marrow Niches In Vivo Engineered Using Carbonate Apatite Honeycomb Bioreactors Open
Hematopoietic stem cell (HSC) transplantation is used to treat blood and immunodeficient diseases. HSC expansion techniques must be developed to prevent complications and ensure reliable therapeutic efficacy. Hence, several studies have at…
View article: Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction
Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction Open
Both the composition and architecture of artificial bone govern bone regeneration. Herein, carbonate apatite (CAp), which has a similar mineral composition to bone, was prepared by immersing calcium carbonate (CaCO 3 ) in a phosphate solut…
View article: In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects
In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects Open
Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granu…
View article: Effects of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects.
Effects of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects. Open
Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granu…
View article: Transformable Carbonate Apatite Chains as a Novel Type of Bone Graft
Transformable Carbonate Apatite Chains as a Novel Type of Bone Graft Open
The aging global population is generating an ever‐increasing demand for bone regeneration. Various materials, including blocks, granules, and sponges, are developed for bone regeneration. However, blocks require troublesome shaping and exh…
View article: Antibacterial and osteogenic thin films on Ti-6Al-4V surface formed by passivation process in copper hydroxide solution
Antibacterial and osteogenic thin films on Ti-6Al-4V surface formed by passivation process in copper hydroxide solution Open
Implant-associated infections are threatening and devastating complications that lead to bone destruction and loss. As a smooth surface is suitable for inhibiting bacterial adhesion, endowing antibacterial activity to the Ti surface withou…
View article: Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration
Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration Open
Synthetic bone grafts are in high demand owing to increased age-related bone disorders in the global aging population. Here, we report fabrication of gear-shaped granules (G-GRNs) for rapid bone healing. G-GRNs possessed six protrusions an…
View article: Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation
Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation Open
Synthetic scaffolds with the ability to prevent fibrous tissue penetration and promote bone augmentation may realize guided bone regeneration without the use of a barrier membrane for dental implantation. Here, we fabricated two types of h…
View article: Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System
Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System Open
Although studies on scaffolds for tissue generation have mainly focused on the chemical composition and pore structure, the effects of scaffold shape have been overlooked. Scaffold shape determines the scaffold surface area (SA) at the sin…
View article: Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation
Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation Open
The HC scaffolds surpassed the various combined scaffolds and growth factors or stem cells in the ability for vertical bone augmentation. Thus, the HC structure is inherently suitable for vertical bone augmentation. Notably, the HC scaffol…
View article: Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks
Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks Open
Porous architecture in bone substitutes, notably the interconnectivity of pores, is a critical factor for bone ingrowth. However, controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved usin…
View article: No-Observed-Effect Level of Silver Phosphate in Carbonate Apatite Artificial Bone on Initial Bone Regeneration
No-Observed-Effect Level of Silver Phosphate in Carbonate Apatite Artificial Bone on Initial Bone Regeneration Open
Fracture-related infections require both treatments for bacteria removal and bone reconstruction. The use of combined broad-spectrum antibacterial silver compounds and artificial bone with high osteogenic activity is considered to be an ef…
View article: Fabrication of vaterite blocks from a calcium hydroxide compact
Fabrication of vaterite blocks from a calcium hydroxide compact Open
Metastable vaterite blocks are expected to show high reactivity. However, they have not been reported to date. In this study, the feasibility of fabricating an artificial vaterite block was investigated by exposing a Ca(OH)2 compact to CO2…
View article: Density Functional Theory-Based Calculation Shed New Light on the Bizarre Addition of Cysteine Thiol to Dopaquinone
Density Functional Theory-Based Calculation Shed New Light on the Bizarre Addition of Cysteine Thiol to Dopaquinone Open
Two types of melanin pigments, brown to black eumelanin and yellow to reddish brown pheomelanin, are biosynthesized through a branched reaction, which is associated with the key intermediate dopaquinone (DQ). In the presence of l-cysteine,…
View article: Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration
Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration Open
Carbonate apatite honeycomb scaffolds achieve barrier membrane-free guided bone regeneration that can resolve the current challenges in vertical bone augmentation.