Ryo Yokomizo
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View article: A smartphone application as a promising tool for large-scale collection of participant data on fertility treatment
A smartphone application as a promising tool for large-scale collection of participant data on fertility treatment Open
In Japan, there is a registry for fertility treatment (the JSOG registry), which is a system that only registers select clinical data related to assisted reproductive technology (ART). This system does not include patient-derived data, so …
View article: Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells
Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells Open
Endometrium is vital to the establishment of pregnancy through its cyclical regeneration, which, when disrupted, can lead to endometrial thinning and Asherman's syndrome (AS). AS is characterized by infertility, pelvic pain, menstrual irre…
View article: Amendment of the Act on the Safety of Regenerative Medicine: A new voyage of regenerative medicine in Japan and the dawn of a new era for young investigators
Amendment of the Act on the Safety of Regenerative Medicine: A new voyage of regenerative medicine in Japan and the dawn of a new era for young investigators Open
Aiming to promote the safe and appropriate provision of regenerative medicine (RM) in Japan, the Japanese government implemented the Act on the Safety of Regenerative Medicine (RM Act) on November 25, 2014. A supplemental rule of th…
View article: Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial
Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial Open
Ferric carboxymaltose (FCM) is widely used to correct anemia and replenish iron stores rapidly, particularly in Western populations. However, lower doses of FCM are typically used in East Asia, with limited research on their effectiveness,…
View article: A Case of Colon Leiomyosarcoma Arising from the Muscularis Mucosae: A Case Report and Literature Review
A Case of Colon Leiomyosarcoma Arising from the Muscularis Mucosae: A Case Report and Literature Review Open
This literature demonstrates CLMS arising from MM and suggests that its pathological diagnosis is associated with disease prognosis.
View article: Regenerative medicine in Obstetrics & Gynecology: Current status under the Act on the Safety of Regenerative Medicine in Japan
Regenerative medicine in Obstetrics & Gynecology: Current status under the Act on the Safety of Regenerative Medicine in Japan Open
The RM Act permits knowledge of the current status of regenerative medicine even for unapproved uses in a specific clinical field. The study findings shall prompt a worldwide discussion regarding the required regulations for therapy and cl…
View article: Prolongation of the Menstrual Cycle After Receipt of the Primary Series and Booster Doses of mRNA Coronavirus Disease 2019 (COVID-19) Vaccination
Prolongation of the Menstrual Cycle After Receipt of the Primary Series and Booster Doses of mRNA Coronavirus Disease 2019 (COVID-19) Vaccination Open
OBJECTIVE: To quantitatively evaluate the effect of a booster vaccination dose against coronavirus disease 2019 (COVID-19) on menstrual cycle in a large-scale retrospective cohort study using a menstrual cycle tracking smartphone applicati…
View article: Novel therapeutic strategies for injured endometrium: intrauterine transplantation of menstrual blood‑derived cells from infertile patients
Novel therapeutic strategies for injured endometrium: intrauterine transplantation of menstrual blood‑derived cells from infertile patients Open
Background Menstrual blood-derived cells show regenerative potential as a mesenchymal stem cell and may therefore be a novel stem cell source of treatment for refractory infertility with injured endometrium. However, there have been few pr…
View article: Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3
Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3 Open
View article: Successful use of single-port laparoscopic surgery for ovarian cyst removal during pregnancy: a case series of three cases
Successful use of single-port laparoscopic surgery for ovarian cyst removal during pregnancy: a case series of three cases Open
Pregnant patients have an increased risk of torsion compared to that seen in nonpregnant patients, and those with larger cysts undergo torsion more frequently, which can cause obstructions during labor. The risks associated with emergent s…
View article: Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3
Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3 Open
Background Melanocytes are an essential part of the epidermis, and their regeneration has received much attention because propagation of human adult melanocytes in vitro is too slow for clinical use. Differentiation from human pluripotent …
View article: Novel therapeutic strategies for injured endometrium: Autologous intrauterine transplantation of menstrual blood-derived cells from infertile patients
Novel therapeutic strategies for injured endometrium: Autologous intrauterine transplantation of menstrual blood-derived cells from infertile patients Open
Background Menstrual blood-derived cells show regenerative potential as a mesenchymal stem cell and may therefore be a novel stem cell source of treatment for refractory infertility with injured endometrium. However, there have been few pr…
View article: Antenatal screening timeline and cutoff scores of the Edinburgh Postnatal Depression Scale for predicting postpartum depressive symptoms in healthy women: a prospective cohort study
Antenatal screening timeline and cutoff scores of the Edinburgh Postnatal Depression Scale for predicting postpartum depressive symptoms in healthy women: a prospective cohort study Open
Background It is worthwhile to identify women at risk of developing postpartum depression during pregnancy. This study aimed to determine the optimal time and cutoff score for antenatal screening for prediction of postpartum depressive sym…
View article: O3C Glass-Class: A Machine-Learning Framework for Prognostic Prediction of Ovarian Clear-Cell Carcinoma
O3C Glass-Class: A Machine-Learning Framework for Prognostic Prediction of Ovarian Clear-Cell Carcinoma Open
Ovarian clear cell carcinoma (OCCC), one of the histopathological types of ovarian cancer, has a poor prognosis when it recurs; however, it is difficult to precisely predict the risk of recurrence. Here, we analyzed pathological images of …
View article: Smartphone application improves fertility treatment-related literacy in a large-scale virtual randomized controlled trial in Japan
Smartphone application improves fertility treatment-related literacy in a large-scale virtual randomized controlled trial in Japan Open
View article: Evaluation of Pregnancy Outcomes of Vitrified-Warmed Blastocyst Transfer before and after Endometrial Receptivity Analysis in Identical Patients with Recurrent Implantation Failure
Evaluation of Pregnancy Outcomes of Vitrified-Warmed Blastocyst Transfer before and after Endometrial Receptivity Analysis in Identical Patients with Recurrent Implantation Failure Open
Background: The clinical value of personalized embryo transfer (pET) guided by the endometrial receptivity analysis (ERA) tests for recurrent implantation failure (RIF) cases is still unclear. The aim of this study is to clarify the effica…
View article: Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma
Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma Open
Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with elevated interleukin-6 (IL-6) expression, resistance to chemotherapy, and increased mortality. Although bevacizumab (Bev) is a wide…
View article: Analysis of Surgical Procedure of Four Cases of Ovarian Pregnancies Treated with Laparoscopic Surgery
Analysis of Surgical Procedure of Four Cases of Ovarian Pregnancies Treated with Laparoscopic Surgery Open
Ovarian pregnancy is a rare disease, accounting for 0.5%–3% of ectopic pregnancies. Ovarian pregnancy risk factors and preoperative diagnosis have been extensively reported. However, its histopathology and surgical findings have been poorl…
View article: Endometrial regeneration with endometrial epithelium: homologous orchestration with endometrial stroma as a feeder
Endometrial regeneration with endometrial epithelium: homologous orchestration with endometrial stroma as a feeder Open
View article: Interleukin-6 As An Enhancer of Anti-Angiogenic Therapy for Ovarian Clear Cell Carcinoma.
Interleukin-6 As An Enhancer of Anti-Angiogenic Therapy for Ovarian Clear Cell Carcinoma. Open
Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) and associated with elevated interleukin-6 (IL-6) expression, resistance to chemotherapy, and increased mortality. Although bevacizumab (Bev) is a widely u…
View article: <i>MicroRNA-34a</i>/IL-6R pathway as a potential therapeutic target for ovarian high-grade serous carcinoma
<i>MicroRNA-34a</i>/IL-6R pathway as a potential therapeutic target for ovarian high-grade serous carcinoma Open
Accumulating evidence has indicated that microRNAs play a critical role in the pathogenesis of human cancers. microRNA-34a (miR-34a) has been shown to be a key regulator of tumor suppression by targeting several cancer-relate…
View article: A case of combined ovarian and intrauterine pregnancies resulting in a live birth after laparoscopic surgery
A case of combined ovarian and intrauterine pregnancies resulting in a live birth after laparoscopic surgery Open
Introduction: Heterotopic pregnancies are rare, with an incidence of approximately 0.003% in a natural ovulation cycle. We report a case of combined ovarian and intrauterine pregnancies, in which laparoscopic surgery confirmed the diagnosi…
View article: Laparoscopic surgery for ovarian epidermoid cyst with preservation of ovarian function
Laparoscopic surgery for ovarian epidermoid cyst with preservation of ovarian function Open
Ovarian epidermoid cyst, an extremely rare tumor occurring mostly in older females, is lined by mature stratified squamous epithelium and distinguishable from mature teratoma by the absence of skin adnexae and other tissues. In imaging, th…
View article: Dedifferentiated endometrial carcinoma: A report of three cases and review of the literature
Dedifferentiated endometrial carcinoma: A report of three cases and review of the literature Open
Dedifferentiated endometrial carcinoma, which is defined microscopically as the co-existence of undifferentiated carcinoma and grade 1 or 2 endometrioid adenocarcinoma, is an aggressive type of cancer regardless of the percentage of undiff…
View article: Innovative 2-port laparoscopic-assisted myomectomy without a morcellator
Innovative 2-port laparoscopic-assisted myomectomy without a morcellator Open
Objective: This study aimed to investigate the utility and safety of 2-port laparoscopic-assisted myomectomy (2P-LAM), performed without a morcellator, in comparison with conventional laparoscopic-assisted myomectomy (C-LAM).
View article: J2340104 Aerodynamics properties of the cloth for the sprotswear
J2340104 Aerodynamics properties of the cloth for the sprotswear Open
The decrease in fluid resistance is one of the important keys for the purpose of shortening of the sports time record. By wearing of a low resistance swimsuit, it still reminds us that there were a lot of large time record shortening in sw…