Ryoichi Yoshimura
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View article: Efficacy of low-dose rate brachytherapy utilizing a mold with gold-198 grains for hard palate and gingival cancer
Efficacy of low-dose rate brachytherapy utilizing a mold with gold-198 grains for hard palate and gingival cancer Open
Objectives Mold therapy using gold-198 grains (Au-mold therapy) is a radical treatment for early stage oral cancer owing to its localized delivery of radiation. Understanding the efficacy and limitations of Au-mold therapy is crucial for o…
View article: Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy
Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy Open
Background To evaluate the efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for recurrent head and neck cancer (rHNC) after radiotherapy. Methods This study was a multicenter prospective clinical trial. Eligibility c…
View article: Radioprotection Performance Evaluation of 3D-Printed and Conventional Heat-Cured Dental Resins for Radiotherapy Prostheses
Radioprotection Performance Evaluation of 3D-Printed and Conventional Heat-Cured Dental Resins for Radiotherapy Prostheses Open
3D printing is increasingly used in dentistry, with biocompatible resins playing a key role. This study compared the radioprotective properties of a commonly used 3D-printed resin (Formlabs surgical guide resin) with traditional heat-cured…
View article: <i>In vitro</i> and <i>in silico</i> study of biological effects on cancer cells in the presence of metallic materials during radiotherapy
<i>In vitro</i> and <i>in silico</i> study of biological effects on cancer cells in the presence of metallic materials during radiotherapy Open
X-ray therapy aims to eliminate tumours while minimizing side effects. Intense mucositis is sometimes induced when irradiating the oral cavity with a dental metal crown (DMC). However, the underlying mechanisms of such inducing radiosensit…
View article: Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis
Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis Open
Background To analyze in a prospective study the long-term safety and efficacy of 3-dimensional conformal radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI) for Japanese women with early breast cancer. Methods B…
View article: A Case of Malignant Transformation of Recurrent Respiratory Papillomatosis That Was Effectively Treated with Pembrolizumab
A Case of Malignant Transformation of Recurrent Respiratory Papillomatosis That Was Effectively Treated with Pembrolizumab Open
Introduction: Recurrent respiratory papillomatosis (RRP) is a benign tumor caused by the human papillomavirus that mainly occurs in the larynx; the tumor is known to show malignant transformation in a small percentage of cases. In this rep…
View article: A Case of Radiation-Induced Brachial Plexopathy Below the Tolerance Dose
A Case of Radiation-Induced Brachial Plexopathy Below the Tolerance Dose Open
This case report details a rare instance of radiation-induced brachial plexopathy (RIBP) occurring below the typical tolerance dose in a 55-year-old woman following chemoradiotherapy for apical non-small cell lung carcinoma. Despite receiv…
View article: Clinical investigation of use of Episil® oral solution in oral mucositis during radiotherapy for head and neck cancer
Clinical investigation of use of Episil® oral solution in oral mucositis during radiotherapy for head and neck cancer Open
Although Episil® has been shown to be effective in improving the pain of OM caused by RT for HNC patients, and medical professionals are required to give careful attention to each patient.
View article: Phase I/II prospective clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer
Phase I/II prospective clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer Open
The effectiveness of HBT were demonstrated by a prospective clinical study. Because the dose goal determined in the protocol was lower than 85 Gy, there is room in improvement for local control. A higher dose might have been needed for tum…
View article: Retrograde Migration of an Au-198 Grain to the Submandibular Gland Post Brachytherapy Treatment of Floor of Mouth Cancer
Retrograde Migration of an Au-198 Grain to the Submandibular Gland Post Brachytherapy Treatment of Floor of Mouth Cancer Open
At our institution, radiation oncologists routinely treat early-stage oral cancer with low-dose-rate brachytherapy (LDR-BRT) using Au-198 grains. In this report, we show a unique case of a patient with a gold grain located within the subma…
View article: Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer
Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer Open
Comprehensive genomic profiling (CGP) provides information regarding cancer-related genetic aberrations. However, its clinical utility in recurrent/metastatic head and neck cancer (R/M HNC) remains unknown. Additionally, predictive biomark…
View article: A Rare Case of Radiation-Induced Liver Disease in Treated Abdominal Lymphoma Showing High [18F]FDG Avidity and Low EOB Uptake Proportional to the Irradiation Dose
A Rare Case of Radiation-Induced Liver Disease in Treated Abdominal Lymphoma Showing High [18F]FDG Avidity and Low EOB Uptake Proportional to the Irradiation Dose Open
A 44-year-old woman presented with high [18F]FDG uptake liver lesion after six courses of R-CHOP and radiotherapy for abdominal DLBCL, which was misdiagnosed as a hepatic invasion. EOB–MRI showed slight T2 hyperintensity, low-intensity DWI…
View article: Clinical Investigation Of Use Of Episil® Oral Solution In Oral Mucositis During Radiotherapy For Head And Neck Cancer
Clinical Investigation Of Use Of Episil® Oral Solution In Oral Mucositis During Radiotherapy For Head And Neck Cancer Open
Objective: Episil ® is a bioadhesive barrier-forming oral liquid gel that has been used in recent years to relieve pain at the onset of oral mucositis (OM) associated with radiotherapy (RT) or chemoradiotherapy (CRT) in patients with head …
View article: Impact of Progressive Site-Directed Therapy in Oligometastatic Castration-Resistant Prostate Cancer on Subsequent Treatment Response
Impact of Progressive Site-Directed Therapy in Oligometastatic Castration-Resistant Prostate Cancer on Subsequent Treatment Response Open
The purpose of this study was to evaluate the impact of progressive site-directed therapy (PSDT) for oligometastatic castration-resistant prostate cancer (OM-CRPC) on the efficacy of subsequent androgen receptor axis-targeted (ARAT) drugs,…
View article: Radiation attenuation properties of materials used to fabricate radiotherapy prostheses <i>in vitro</i> study
Radiation attenuation properties of materials used to fabricate radiotherapy prostheses <i>in vitro</i> study Open
PVS showed higher attenuating radiation exposure compared with PMMA.
View article: Efficacy and Safety of Induction Chemotherapy and/or External Beam Radiotherapy Followed by Brachytherapy in Patients With Tongue Cancer
Efficacy and Safety of Induction Chemotherapy and/or External Beam Radiotherapy Followed by Brachytherapy in Patients With Tongue Cancer Open
Induction therapy contributed to the efficacy of the subsequent BT in LC rate.
View article: Prognostic impact of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue: a retrospective study
Prognostic impact of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue: a retrospective study Open
Squamous cell carcinoma (SCC) of the tongue rarely metastasizes to the lingual lymph nodes (LLNs), which are inconstant nodes and often situated outside the areas of basic tongue tumor surgery. The current study evaluated the clinicopathol…
View article: Nonmetastatic castration‐resistant prostate cancer treated with salvage focal brachytherapy after external beam radiotherapy
Nonmetastatic castration‐resistant prostate cancer treated with salvage focal brachytherapy after external beam radiotherapy Open
Introduction The efficacy of salvage local therapy after external beam radiotherapy has recently gained attention. However, a challenge with these therapies is the risk of significant genitourinary and gastrointestinal toxicity. Focal brac…
View article: CT-Guided Pelvic Lymph Nodal Brachytherapy
CT-Guided Pelvic Lymph Nodal Brachytherapy Open
Purpose This is a report of our initial experience using computed tomography (CT)-guided interstitial high dose rate (HDR) brachytherapy to treat bulky pelvic nodal metastases as a part of definitive radiotherapy. Material and methods Betw…
View article: The clinical utility of comprehensive genomic profiling for recurrent / metastatic head and neck cancer
The clinical utility of comprehensive genomic profiling for recurrent / metastatic head and neck cancer Open
頭頸部癌患者14例18件に対しFoundationOne CDxなどのがん遺伝子パネル検査を使用し,組織検体15件(83.3%),血液検体3件(16.6%)における遺伝子変異の解析を行った。原発部位別では,舌癌が6例(42.8%)と最多で,検出された遺伝子変異としてはTP53,TERT promoter,CDKN2Aなどであり,全ゲノム解析を用いた既報と矛盾しない結果となった。14例のうち,治療候補があった症例は11 例(78.6%)であったが,実際に遺伝子パネル検査に基づ…
View article: Outcomes after reirradiation of spinal metastasis with stereotactic body radiation therapy (SBRT): a retrospective single institutional study
Outcomes after reirradiation of spinal metastasis with stereotactic body radiation therapy (SBRT): a retrospective single institutional study Open
This study was aimed at assessing the feasibility and toxicity of using stereotactic body radiation therapy (SBRT) for reirradiation of spinal metastatic tumors. We conducted a retrospective review, from our institutional database, of the …
View article: Inter-fractional variations in the dosimetric parameters of accelerated partial breast irradiation using a strut-adjusted volume implant
Inter-fractional variations in the dosimetric parameters of accelerated partial breast irradiation using a strut-adjusted volume implant Open
The aim of the study was to evaluate inter-fractional dosimetric variations for high-dose rate breast brachytherapy using a strut-adjusted volume implant (SAVI). For the nine patients included, dosimetric constraints for treatment were as …
View article: Intensity Modulated Radiation Therapy for Syringomatous Carcinoma of the Face: A Case Report
Intensity Modulated Radiation Therapy for Syringomatous Carcinoma of the Face: A Case Report Open
Sweat gland carcinomas are extremely rare tumors. The age-adjusted incidence rate of cutaneous appendageal carcinomas, including sweat gland carcinomas, is 5.1 per 1 million person-years.1 The main treatment method is wide local excision a…