Ryohei Shoji
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View article: p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis
p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis Open
Pancreatic ductal adenocarcinoma (PDAC)-associated pancreatic stellate cells (PSCs) promote PDAC tumor progression. Notably, PDAC tumors display enhanced macropinocytosis, resulting in enhanced uptake of extracellular particles, including …
View article: Surgical resection of inoperable Lynch syndrome-related colorectal cancer following pembrolizumab treatment: Report of two cases
Surgical resection of inoperable Lynch syndrome-related colorectal cancer following pembrolizumab treatment: Report of two cases Open
View article: D3 lymph node dissection in colon cancer patients aged 90 years and over: Is it justified? A multi‐institutional retrospective study
D3 lymph node dissection in colon cancer patients aged 90 years and over: Is it justified? A multi‐institutional retrospective study Open
Aim The oncological benefit of D3 lymph node dissection (D3 LND) for colon cancer in patients aged ≥90 years remains unclear. This study aimed to evaluate the impact of D3 LND on outcomes in this specific, vulnerable population. Method Thi…
View article: The Geriatric Nutritional Risk Index: A Key Indicator of Perioperative Outcome in Oldest-old Patients With Colorectal Cancer
The Geriatric Nutritional Risk Index: A Key Indicator of Perioperative Outcome in Oldest-old Patients With Colorectal Cancer Open
Preoperative GNRI effectively identifies oldest-old patients with CRC at increased risk for postoperative complications. A GNRI ≤98 correlates with poorer nutritional status and impaired geriatric functional parameters. These findings high…
View article: Early C-reactive protein as a predictive biomarker for postoperative complications following robot-assisted surgery for rectal cancer
Early C-reactive protein as a predictive biomarker for postoperative complications following robot-assisted surgery for rectal cancer Open
This retrospective cohort study aimed to assess the predictive value of early postoperative C-reactive protein (CRP) levels for complications following robot-assisted rectal surgery (RARS) for rectal cancer. We analyzed data from 117 conse…
View article: A case of retrograde colonic intussusception by tubulovillous adenoma
A case of retrograde colonic intussusception by tubulovillous adenoma Open
View article: ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy
ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy Open
RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes plays a role in cancer progression. However, its clinical significance in metastatic colorectal cancer (CRC) remains unclear. This study aimed to evaluate whether ADAR1 expres…
View article: Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine
Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine Open
Dendritic cells (DCs) transduced with replication-deficient, wild-type human p53-expressing adenovirus Ad-p53 (Ad-p53 DCs) induce p53-targeting cytotoxic T lymphocytes (CTLs). However, the antitumor efficacy of Ad-p53 DCs is diminished by …
View article: Severe Anemia Caused by a Colorectal Lipoma With Central Erosions: A Case Report
Severe Anemia Caused by a Colorectal Lipoma With Central Erosions: A Case Report Open
Colorectal lipomas are benign tumors that are often asymptomatic and discovered incidentally. In most cases, they can be managed conservatively with observation. We report the case of a man in his 70s with a colorectal lipoma located in th…
View article: Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients
Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients Open
Low NLR and high ADAR1 were predictive markers for a positive response to the FTD/TPI plus bevacizumab regimen associated with prolonged PFS. The FTD/TPI plus bevacizumab regimen should be proactively implemented in the low NLR and high AD…
View article: Investigation of perioperative changes in sciatic nerve stiffness in patients with lumbar disc herniation using shear wave elastography:A longitudinal cohort study
Investigation of perioperative changes in sciatic nerve stiffness in patients with lumbar disc herniation using shear wave elastography:A longitudinal cohort study Open
Sciatic nerve stiffness on the affected side was decreased at one week postoperatively compared with preoperatively. In addition, sciatic nerve stiffness on the affected side was correlated with leg pain severity.
View article: Clinical Impacts of Minimally Invasive Transperineal Abdominoperineal Resection in Crohn's Disease: A Retrospective Analysis
Clinical Impacts of Minimally Invasive Transperineal Abdominoperineal Resection in Crohn's Disease: A Retrospective Analysis Open
Introduction Crohn's disease (CD) often leads to complex anorectal complications, posing significant challenges in surgical management. Transperineal abdominoperineal resection (TpAPR) has emerged as a minimally invasive alternative to APR…
View article: Obese Patient with Gastric Diverticulum Undergoing Laparoscopic Sleeve Gastrectomy Guided by Preoperative Endoscopic Measurement: A Case Report and Literature Review
Obese Patient with Gastric Diverticulum Undergoing Laparoscopic Sleeve Gastrectomy Guided by Preoperative Endoscopic Measurement: A Case Report and Literature Review Open
This case highlights the importance of thorough preoperative evaluation when performing LSG in patients with gastric diverticulum. Accurate endoscopic measurement of the diverticulum's location aids in determining the optimal resection lin…
View article: Robot-Assisted Laparoscopic Resection With the Transanal Approach for Massive Rectal Gastrointestinal Stromal Tumor: A Case Report
Robot-Assisted Laparoscopic Resection With the Transanal Approach for Massive Rectal Gastrointestinal Stromal Tumor: A Case Report Open
Rectal gastrointestinal stromal tumors (GISTs) are often asymptomatic and may be detected as giant tumors. This may require highly invasive surgery for radical resection. Here, we describe a 74-year-old man with a locally advanced non-meta…
View article: Subjective global assessment for nutritional screening and its impact on surgical outcomes: A prospective study in older patients with colorectal cancer
Subjective global assessment for nutritional screening and its impact on surgical outcomes: A prospective study in older patients with colorectal cancer Open
Purpose Our perioperative management center provides preoperative intervention and functional and nutritional assessments for colorectal cancer patients aged over 75 years. This study evaluated the associations of preoperative nutritional …
View article: A Case of Laparoscopic Left Hemicolectomy for Transverse Colon Cancer With Severe Obesity Performed Safely by Multidisciplinary Perioperative Management
A Case of Laparoscopic Left Hemicolectomy for Transverse Colon Cancer With Severe Obesity Performed Safely by Multidisciplinary Perioperative Management Open
A minimally invasive approach using laparoscopy or robotics has become the standard procedure in surgery for colorectal cancer. However, obesity is considered to be associated with a poor prognosis in laparoscopic colorectal surgery. Perio…
View article: Primary ileal myeloid sarcoma presenting with bowel obstruction: a case report
Primary ileal myeloid sarcoma presenting with bowel obstruction: a case report Open
View article: Calcium polystyrene sulfonate-induced rectal ulcer causing E. coli native-valve infective endocarditis
Calcium polystyrene sulfonate-induced rectal ulcer causing E. coli native-valve infective endocarditis Open
Escherichia coli -associated native-valve infective endocarditis is a rare disease that affects elderly patients with underlying risk factors such as diabetes mellitus, malignancy, and renal failure. Long-term use of calcium polystyrene su…
View article: Calcium polystyrene sulfonate-induced rectal ulcer causing E. coli native-valve infective endocarditis
Calcium polystyrene sulfonate-induced rectal ulcer causing E. coli native-valve infective endocarditis Open
Escherichia coli-associated native valve infective endocarditis is a rare disease that affects elderly patients with underlying risk factors such as diabetes mellitus, malignancy, and renal failure. Long-term use of calcium polystyrene sul…
View article: Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer
Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer Open
View article: Case of Small Intestinal Angioectasia Resected with Preoperative Video-assisted Thoracoscopic Surgery Marking
Case of Small Intestinal Angioectasia Resected with Preoperative Video-assisted Thoracoscopic Surgery Marking Open
症例は71歳，男性．既往に胆嚢十二指腸瘻に対する開腹手術歴があった．術後9年目頃から繰り返す下血，貧血の進行を主訴に入退院を繰り返していた．それまで各種検査を施行していたが，明らかな出血源は不明のままであった．しかし，今回の入院時に撮影した腹部造影CT検査では上腸間膜静脈の閉塞と，小腸，上行結腸辺縁静脈の拡張，側副血行路の発達を認め，また活動性出血時に撮影した腹部造影CT検査で臍近傍の小腸壁の一部に造影剤の貯留を認めたため，この部位の腸管壁に術前VATS（video-ass…
View article: A Case of Duodenal Papillary Cancer 30 Years after Total Colectomy for Familial Adenomatous Polyposis
A Case of Duodenal Papillary Cancer 30 Years after Total Colectomy for Familial Adenomatous Polyposis Open
症例は57歳，女性．家族性大腸腺腫症（familial adenomatous polyposis:FAP）のため，直腸癌，腹腔内デスモイド腫瘍，直腸癌肝転移，直腸癌肺転移の治療既往がある．心窩部痛・嘔気・嘔吐を主訴に近医を受診し，絞扼性イレウスの疑いにて当院救急外来へ救急搬送された．採血，造影CTにて急性膵炎と診断され，当院内科にて加療．上部消化管内視鏡にて十二指腸乳頭部に腫瘤を認め，生検にて乳頭部癌が強く疑われたため当科紹介となり，膵頭十二指腸切除術を施行した．術後経過…