Ryoichi Kawamura
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View article: Cross-sectional and longitudinal associations of weekly step patterns with metabolic syndrome in middle-aged and older Japanese adults: The Toon Health Study
Cross-sectional and longitudinal associations of weekly step patterns with metabolic syndrome in middle-aged and older Japanese adults: The Toon Health Study Open
Total step volume showed a stronger association with MetS than step frequency. Nonetheless, regularly achieving step thresholds may be associated with potential benefits within specific activity ranges.
View article: Pulse Rate Variability and All-Cause Mortality Risk in the General Japanese Population
Pulse Rate Variability and All-Cause Mortality Risk in the General Japanese Population Open
View article: The Association Between Dietary Fat Intake and Mild Cognitive Impairment in Japanese Men and Women: The Toon Health Study
The Association Between Dietary Fat Intake and Mild Cognitive Impairment in Japanese Men and Women: The Toon Health Study Open
Previous studies have shown that dietary fatty acid intake is associated with the risk of developing dementia. However, its association with mild cognitive impairment (MCI) remains controversial. Therefore, we aimed to examine the associat…
View article: Are There Sex Differences in Brain Activity in Response to Active Tactile Stimulation?
Are There Sex Differences in Brain Activity in Response to Active Tactile Stimulation? Open
Tactile information plays a crucial role in object recognition, spatial localization, and motor control. In elucidating the neural basis of these processes, it is critically important to clarify the underlying neural mechanisms of active t…
View article: Association Between Low-Carbohydrate Diet Scores and Incidence of Hypertension Among the Middle-Aged Japanese Population: The Toon Health Study
Association Between Low-Carbohydrate Diet Scores and Incidence of Hypertension Among the Middle-Aged Japanese Population: The Toon Health Study Open
This study investigates the association between Low-Carbohydrate Diet (LCD) score and the incidence of hypertension in the Japanese population. This cohort study was conducted in an ongoing longitudinal study, the Toon Health Study. Hypert…
View article: Patterns of daily ambulatory activity and the onset of metabolic syndrome in middle-aged and older Japanese women: the Toon Health Study
Patterns of daily ambulatory activity and the onset of metabolic syndrome in middle-aged and older Japanese women: the Toon Health Study Open
AA patterns accumulating a certain number or more steps, regardless of the intensity of AA, may help reduce the risk of MetS compared to inactive AA patterns.
View article: The Longitudinal Relationship between Educational Level and Arterial Stiffness: The Toon Health Study
The Longitudinal Relationship between Educational Level and Arterial Stiffness: The Toon Health Study Open
Education is a factor that affects arterial stiffness in women of ≥ 65 years of age. These results suggest that educational level affects arterial stiffness, depending on sex and age.
View article: Halopseudomonas sp. MFKK-1: A marine-derived bacterium capable of degrading poly(butylene succinate-co-adipate), poly(ε-caprolactone), and poly(butylene adipate-co-terephthalate) in marine ecosystems
Halopseudomonas sp. MFKK-1: A marine-derived bacterium capable of degrading poly(butylene succinate-co-adipate), poly(ε-caprolactone), and poly(butylene adipate-co-terephthalate) in marine ecosystems Open
View article: Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study
Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study Open
The G-A haplotype, accompanied by latent low skeletal muscle mass and visceral obesity, led to the deterioration of insulin resistance over a 5 year period in this cohort, possibly through the altered expression of mitophagy-related genes.
View article: Prediction of future insulin‐deficiency in glutamic acid decarboxylase autoantibody enzyme‐linked immunosorbent assay‐positive patients with slowly‐progressive type 1 diabetes
Prediction of future insulin‐deficiency in glutamic acid decarboxylase autoantibody enzyme‐linked immunosorbent assay‐positive patients with slowly‐progressive type 1 diabetes Open
Aims/Introduction This study aimed to identify risk factors that contribute to the progression of slowly‐progressive type 1 diabetes by evaluating the positive predictive value (PPV) of factors associated with the progression to an insulin…
View article: Pulse rate variability and health-related quality of life assessment with the Short Form-8 Japanese version in the general Japanese population
Pulse rate variability and health-related quality of life assessment with the Short Form-8 Japanese version in the general Japanese population Open
View article: Effect of high-amylose rice “Hoshinishiki” on postprandial glucose levels measured by continuous glucose monitoring in patients with diabetes
Effect of high-amylose rice “Hoshinishiki” on postprandial glucose levels measured by continuous glucose monitoring in patients with diabetes Open
We examined the effect of consuming Hoshinishiki, a type of high-amylose rice, on postprandial glucose as measured by continuous glucose monitoring in diabetes patients. A single-blinded clinical trial involving 11 hospitalized patients di…
View article: Heart rate variability and the short form-8 Japanese version for health-related quality of life in the general Japanese population
Heart rate variability and the short form-8 Japanese version for health-related quality of life in the general Japanese population Open
Self-rated health predicts mortality. Autonomic dysfunction is thought to be a relevant biological mechanism but has not been investigated in the general population. A cross-sectional study was conducted on 5,908 Japanese men and women age…
View article: Longitudinal Changes in Arterial Stiffness Associated with Physical Activity Intensity: The Toon Health Study
Longitudinal Changes in Arterial Stiffness Associated with Physical Activity Intensity: The Toon Health Study Open
In summary, this study provides evidence to support the existence of a threshold for beneficial levels of MVPA in the prevention of arterial stiffness. Furthermore, this study suggests that exceeding this threshold may exert similar effect…
View article: The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study
The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study Open
View article: Resistin G–A haplotype at <scp>SNP</scp>‐420/‐358 is associated with the latent sarcopenic obesity index in the toon genome study
Resistin G–A haplotype at <span>SNP</span>‐420/‐358 is associated with the latent sarcopenic obesity index in the toon genome study Open
Aim/Introduction Resistin, which induces insulin resistance, is mainly expressed in monocytes/macrophages in humans. We reported previously that serum resistin was highest in the G–A haplotype defined by resistin single nucleotide polymorp…
View article: The Relationship Between Oral Health and Cognitive Function Among Community‐Dwelling Japanese Older Adults: A Cross-sectional Study Using Toon Health Study Data
The Relationship Between Oral Health and Cognitive Function Among Community‐Dwelling Japanese Older Adults: A Cross-sectional Study Using Toon Health Study Data Open
Background This study aimed to investigate the relationship between tooth loss and cognitive function in community-dwelling elderly. Methods A total of 438 men and 715 women aged 60–84 years who participated in the Toon Study—an epidemiolo…
View article: Salivary Alpha-amylase Activity and Mild Cognitive Impairment Among Japanese Older Adults: The Toon Health Study
Salivary Alpha-amylase Activity and Mild Cognitive Impairment Among Japanese Older Adults: The Toon Health Study Open
Dementia is an important global issue, and early detection and intervention are critical.There is growing interest in identifying mild cognitive impairment (MCI) and intervening in patients' lifestyle-related behaviors in clinical and comm…
View article: Latent profile analysis approach to the relationship between daily ambulatory activity patterns and metabolic syndrome in middle-aged and elderly Japanese individuals: The Toon Health Study
Latent profile analysis approach to the relationship between daily ambulatory activity patterns and metabolic syndrome in middle-aged and elderly Japanese individuals: The Toon Health Study Open
AA pattern involving a certain number or greater of steps accumulated through not only MVAA but also LIAA may help reduce the risk of MetS compared to inactive AA pattern.
View article: Association of Fish and Omega-3 Fatty Acid Intake with Carotid Intima-Media Thickness in Middle-Aged to Elderly Japanese Men and Women: The Toon Health Study
Association of Fish and Omega-3 Fatty Acid Intake with Carotid Intima-Media Thickness in Middle-Aged to Elderly Japanese Men and Women: The Toon Health Study Open
Fish and omega-3 fatty acid consumption is known to be beneficial for cardiometabolic health. However, the related evidence for individuals with a relatively higher intake of fish or omega-3 unsaturated fatty acids, e.g., Japanese individu…
View article: Salivary Alpha-Amylase Activity and Mild Cognitive Impairment among Japanese Older Adults: The Toon Health Study
Salivary Alpha-Amylase Activity and Mild Cognitive Impairment among Japanese Older Adults: The Toon Health Study Open
Elevation of salivary alpha-amylase was associated with mild cognitive impairment among Japanese community-dwelling older adults. This suggests that salivary alpha-amylase is a useful objective marker of psychological stress responses asso…
View article: Recurrent Hypoglycemia Due to a High Titer of Insulin Antibody in Response to Exogenous Insulin Administration in Two Cases of Type 1 Diabetes
Recurrent Hypoglycemia Due to a High Titer of Insulin Antibody in Response to Exogenous Insulin Administration in Two Cases of Type 1 Diabetes Open
In the first case, a 60-year-old man who was using continuous subcutaneous insulin infusion (CSII), developed recurrent hypoglycemia due to insulin antibodies. This is the first report of such a case using CSII. In the second case, a 70-ye…
View article: Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study
Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study Open
View article: A Cross-Sectional Study of the Relationship of Timed Up & Go Test with Physical Characteristics and Physical Activity in Healthy Japanese: The Toon Health Study
A Cross-Sectional Study of the Relationship of Timed Up & Go Test with Physical Characteristics and Physical Activity in Healthy Japanese: The Toon Health Study Open
This study evaluated the Timed Up & Go test (TUG) among healthy Japanese individuals without walking problems to clarify the relationship of TUG performance with physical characteristics and physical activity according to sex and age group…
View article: The association between alcohol consumption and Mild Cognitive Impairment: the Toon Health Study
The association between alcohol consumption and Mild Cognitive Impairment: the Toon Health Study Open
Our findings suggest that alcohol consumption in moderation may contribute to the prevention of MCI development in men.
View article: Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study
Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study Open
Aims/Introduction Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus…
View article: Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study
Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study Open
Aims/Introduction Resistin is an adipocyte‐derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self‐reported intake of n −3 polyunsaturat…
View article: The fluctuation in sympathetic nerve activity around wake-up time was positively associated with not only morning but also daily glycemic variability in subjects with type 2 diabetes
The fluctuation in sympathetic nerve activity around wake-up time was positively associated with not only morning but also daily glycemic variability in subjects with type 2 diabetes Open
In T2D, the fluctuation in fasting sympathetic nerve activity around wake-up was positively associated with not only morning but also daily GV.
View article: Variants in the <i>BACH2</i> and <i>CLEC16A</i> gene might be associated with susceptibility to insulin‐triggered type 1 diabetes
Variants in the <i>BACH2</i> and <i>CLEC16A</i> gene might be associated with susceptibility to insulin‐triggered type 1 diabetes Open
Aim/Introduction Insulin administration was found to trigger type 1 diabetes in six Japanese type 2 diabetes patients with type 1 diabetes high‐risk human leukocyte antigen class II and the class I allele of the insulin gene variable numbe…
View article: Seasonal Variation in Severe Glucose-lowering Drug-induced Hypoglycemia in Patients with Type 2 Diabetes
Seasonal Variation in Severe Glucose-lowering Drug-induced Hypoglycemia in Patients with Type 2 Diabetes Open
Objective Glucose-lowering drug-induced hypoglycemia is a serious complication and there have been a few reports of seasonal variations in hypoglycemia in patients with type 2 diabetes. The aim of the present study was to examine the assoc…