Ryoichi Kimura
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View article: Identification of a novel stomatal opening chemical, PP242, that inhibits early abscisic acid signal transduction in guard cells
Identification of a novel stomatal opening chemical, PP242, that inhibits early abscisic acid signal transduction in guard cells Open
Plants control their stomatal apertures to optimize carbon dioxide uptake and water loss. Stomata open in response to light through the phosphorylation of the penultimate residue, Thr, of plasma membrane (PM) H+-ATPase in guard cells. Stom…
View article: Adverse Effects of Aβ1-42 Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons
Adverse Effects of Aβ1-42 Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons Open
Aβ1-42 (amyloid beta) oligomers, the major neurotoxic culprits in Alzheimer’s disease, initiate early pathophysiological events, including neuronal hyperactivity, that underlie aberrant network activity and cognitive impairment. Although s…
View article: Adverse Effects of Aβ1-42 Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons
Adverse Effects of Aβ1-42 Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons Open
Aβ1-42 (amyloid beta) oligomers, the major neurotoxic culprits in Alzheimer's disease, initiate early pathophysiological events, including neuronal hyperactivity, that underlie aberrant network activity and cognitive impairment. Altho…
View article: Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro
Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro Open
Extracellular vesicles (EVs) are double membrane structures released by all cell types with identified roles in the generation, transportation, and degradation of amyloid-β protein (Aβ) oligomers in Alzheimer’s disease (AD). EVs are thus i…
View article: Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models.
Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models. Open
Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a Class B G protein-coupled receptor (GPCR), is a potential modulator of Alzheimer’s disease (AD) pathogenesis. However, past pharmacological approaches have fai…
View article: Demand for TRU nuclide cross-sections from the view point of TRU production and radiotoxicity
Demand for TRU nuclide cross-sections from the view point of TRU production and radiotoxicity Open
The environmental load reduction of nuclear energy is required in Japan, from\nthe view point of public acceptance. Here, the long-term radiotoxicity of\nradioactive wastes is dominated by trans-uranium (TRU) nuclides. We evaluated\nthe ef…
View article: [P1–118]: AMYLIN RECEPTOR MODULATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY
[P1–118]: AMYLIN RECEPTOR MODULATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY Open
Alzheimer's disease (AD) is characterized by accumulation of amyloid-β peptide (Aβ) in the brain regions that subserve memory and cognition. We have previously demonstrated that effects of Aβ1–42 and human amylin on hippocampal long-term p…