Ryoichiro Doi
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View article: Anti-tumor Effects of Erlotinib<i>via</i>Thymidylate Synthase Down-regulation in Pancreatic Cancer Cells
Anti-tumor Effects of Erlotinib<i>via</i>Thymidylate Synthase Down-regulation in Pancreatic Cancer Cells Open
Erlotinib could have a synergistic anti-tumor effect when combined with gemcitabine via down-regulation of TS expression.
View article: Association between health-related quality of life and perioperative exercise capacity in older postoperative patients with non-small cell lung cancer
Association between health-related quality of life and perioperative exercise capacity in older postoperative patients with non-small cell lung cancer Open
HRQOL recovered to preoperative levels 3 months after surgery; the 6MWD decrease before and after surgery was associated with HRQOL recovery than other clinically relevant factors. These results suggest the importance of active early mobil…
View article: Spheroid Morphology of Lung Cancer Cell Lines Correlates with Oncological Profiles
Spheroid Morphology of Lung Cancer Cell Lines Correlates with Oncological Profiles Open
We assessed the correlation between Multicellular tumor spheroids (MCTS) morphology and the oncological profile of lung cancer cells. MCTS were generated in five lung cancer cell lines and classified into Type–A MCTS, which showed strong a…
View article: Post-thoracotomy pain syndrome in the era of minimally invasive thoracic surgery
Post-thoracotomy pain syndrome in the era of minimally invasive thoracic surgery Open
Post-thoracotomy pain syndrome (PTPS) is defined as pain around the wound that persists for more than 2 months after surgery. Persistent pain not only increases the use of analgesics and their side effects but also causes many social probl…
View article: Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models
Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models Open
Background Researchers are focusing on cellular therapy for chronic obstructive pulmonary disease (COPD) using mesenchymal stem cells (MSCs), with human bone marrow-derived MSCs (hBM-MSCs) leading the way. However, BM-MSCs may not be as op…
View article: Curved Axillary Incision with Video-Assisted Thoracoscopic Surgery: An Alternative Approach for Teenage Female with Large Apical Chest Wall Tumor
Curved Axillary Incision with Video-Assisted Thoracoscopic Surgery: An Alternative Approach for Teenage Female with Large Apical Chest Wall Tumor Open
Primary chest wall tumors are rare, their common clinical features are not well known, and surgical resection remains the main treatment. Apical chest wall tumors require large skin incisions and dissection of the chest wall muscles, makin…
View article: Does the human leukocyte antigen’s relatively homogeneous genetic background relate to better lung transplantation outcomes in Japan?
Does the human leukocyte antigen’s relatively homogeneous genetic background relate to better lung transplantation outcomes in Japan? Open
The outcomes of lung transplantation in Japan are better than in other countries; however, the reasons for this are unclear. While the genetic background of the Japanese may be relatively homogeneous compared with those of other countries,…
View article: A novel ex vivo lung cancer model based on bioengineered rat lungs
A novel ex vivo lung cancer model based on bioengineered rat lungs Open
Introduction: Two-dimensional cell cultures have contributed substantially to lung cancer research, but 3D cultures are gaining attention as a new, more efficient, and effective research model. A model reproducing the 3D characteristics an…
View article: Adipose-Derived Mesenchymal Stem Cells Attenuate Immune Reactions Against Pig Decellularized Bronchi Engrafted into Rat Tracheal Defects
Adipose-Derived Mesenchymal Stem Cells Attenuate Immune Reactions Against Pig Decellularized Bronchi Engrafted into Rat Tracheal Defects Open
Decellularized scaffolds are promising biomaterials for tissue and organ reconstruction; however, strategies to effectively suppress the host immune responses toward these implants, particularly those without chemical crosslinking, remain …
View article: Timing of Mesenchymal Stromal Cell Therapy Defines its Immunosuppressive Effects in a Rat Lung Transplantation Model
Timing of Mesenchymal Stromal Cell Therapy Defines its Immunosuppressive Effects in a Rat Lung Transplantation Model Open
Cell therapy using mesenchymal stromal cells (MSCs) is being studied for its immunosuppressive effects. In organ transplantation, the amount of MSCs that accumulate in transplanted organs and other organs may differ depending on administra…
View article: Spontaneous pleural aspergillosis in an immunocompetent young adult treated with minimally invasive surgery
Spontaneous pleural aspergillosis in an immunocompetent young adult treated with minimally invasive surgery Open
Spontaneous cases of pleural aspergillosis in healthy adults are rare, and the optimal therapeutic approach has not been established. Here we report a rare case of spontaneous pleural aspergillosis in an otherwise healthy young adult. Two-…
View article: Donor and Recipient Adipose-Derived Mesenchymal Stem Cell Therapy for Rat Lung Transplantation
Donor and Recipient Adipose-Derived Mesenchymal Stem Cell Therapy for Rat Lung Transplantation Open
Collectively, the results indicate that allogenic ADMSCs, regardless of their origin, may exert similar immunosuppressive effects in clinical organ transplantation.
View article: Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models
Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models Open
Malignant pleural mesothelioma (MPM) is a highly malignant disease that develops after asbestos exposure. Although the number of MPM cases is predicted to increase, no effective standard therapies have been established. The novel radiosens…
View article: Mirogabalin treatment of postoperative neuropathic pain after thoracic surgery: study protocol for a multicenter, randomized, open-label, parallel-group, interventional trial
Mirogabalin treatment of postoperative neuropathic pain after thoracic surgery: study protocol for a multicenter, randomized, open-label, parallel-group, interventional trial Open
Japan Registry of Clinical Trials Identifier: jRCTs071200053.
View article: Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells
Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells Open
With the emergence of coronavirus disease-2019, researchers have gained interest in the therapeutic efficacy of mesenchymal stem/stromal cells (MSCs) in acute respiratory distress syndrome; however, the mechanisms of the therapeutic effect…
View article: Lung Microvascular Niche, Repair, and Engineering
Lung Microvascular Niche, Repair, and Engineering Open
Biomaterials have been used for a long time in the field of medicine. Since the success of "tissue engineering" pioneered by Langer and Vacanti in 1993, tissue engineering studies have advanced from simple tissue generation to whole organ …
View article: Alteration of the extracellular matrix and alpha‐gal antigens in the rat lung scaffold reseeded using human vascular and adipogenic stromal cells
Alteration of the extracellular matrix and alpha‐gal antigens in the rat lung scaffold reseeded using human vascular and adipogenic stromal cells Open
Regenerated organs are expected to solve the problem of donor organ shortage in transplantation medicine. One approach to lung regeneration is to decellularize the organ and reseed it with selected cells. An advantage of the procedure is r…
View article: Replacement of Rat Tracheas by Layered, Trachea‐Like, Scaffold‐Free Structures of Human Cells Using a Bio‐3D Printing System
Replacement of Rat Tracheas by Layered, Trachea‐Like, Scaffold‐Free Structures of Human Cells Using a Bio‐3D Printing System Open
Current scaffold‐based tissue engineering approaches are subject to several limitations, such as design inflexibility, poor cytocompatibility, toxicity, and post‐transplant degradation. Thus, scaffold‐free tissue‐engineered structures can …
View article: A case of emergent operation for a life-threatening infectious mediastinal cyst
A case of emergent operation for a life-threatening infectious mediastinal cyst Open
Mediastinal bronchogenic cysts with life-threatening complications are rarely reported in adults. However, this case was life-threatening due to airway and vascular compression; emergent surgical care should be considered in such cases.
View article: Cephalic Vein Cut-down for Totally Implantable Central Venous Access Devices With Preoperative Ultrasonography by Surgical Residents
Cephalic Vein Cut-down for Totally Implantable Central Venous Access Devices With Preoperative Ultrasonography by Surgical Residents Open
CV cut-down can be safely performed by surgical residents under the use of preoperative US.
View article: Sodium hydroxide based non-detergent decellularizing solution for rat lung
Sodium hydroxide based non-detergent decellularizing solution for rat lung Open
Lung transplantation is the last option for the treatment of end stage chronic lung disorders. Because the shortage of donor lung organs represents the main hurdle, lung regeneration has been considered to overcome this hurdle. Recellulari…