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View article: Identification and verification of novel therapeutic agents for diabetic kidney disease based on exosome-targeted high-throughput chemical screening
Identification and verification of novel therapeutic agents for diabetic kidney disease based on exosome-targeted high-throughput chemical screening Open
Exosomes are important mediators of intercellular communication and play key roles in the regulation of pathophysiological processes. In diabetic kidney disease (DKD), it has been reported that macrophages recruited in the mesangial region…
View article: POS-018 A NOVEL ATP-RETAINING COMPOUND, KUS121, ENHANCES ER-ASSOCIATED DEGRADATION AND EXERTS RENOPROTECTIVE EFFECTS AGAINST ACUTE KIDNEY INJURY
POS-018 A NOVEL ATP-RETAINING COMPOUND, KUS121, ENHANCES ER-ASSOCIATED DEGRADATION AND EXERTS RENOPROTECTIVE EFFECTS AGAINST ACUTE KIDNEY INJURY Open
Acute kidney injury (AKI) is a great concern for global public health, which not only is associated with high mortality but may give rise to chronic kidney disease and other organ dysfunction even after recovery. Although there has been an…
View article: POS-328 SUPPRESSION OF ER-ASSOCIATED DEGRADATION BY INTRAGLOMERULAR CROSS-COMMUNICATION BETWEEN MESANGIAL CELLS AND PODOCYTES CAUSES PODOCYTE INJURY IN DIABETIC KIDNEY DISEASE
POS-328 SUPPRESSION OF ER-ASSOCIATED DEGRADATION BY INTRAGLOMERULAR CROSS-COMMUNICATION BETWEEN MESANGIAL CELLS AND PODOCYTES CAUSES PODOCYTE INJURY IN DIABETIC KIDNEY DISEASE Open
Mesangial lesions and podocyte injury are essential manifestations of the progression of diabetic kidney disease (DKD). Although cross-communication between mesangial cells (MCs) and podocytes has recently been suggested by the results of …
View article: Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice
Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice Open
Background Osteocrin (OSTN), a bone-derived humoral factor, was reported to act on heart and bone by potentiating the natriuretic peptide (NP) system. Ostn gene polymorphisms have been associated with renal function decline, but its pathop…
View article: Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review
Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review Open
Background Pembrolizumab, a highly selective humanized monoclonal IgG4κ isotype antibody against PD-1, is one of the immune checkpoint inhibitors approved for treatment of various cancers. The most frequent immune-related adverse events in…