Ryosuke Doi
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View article: Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence Open
Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which causes numerous morbidities and economic burdens in human populations. Mechanisms implicated in age-related sarcopenia or frailty include inflammation, mu…
View article: Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types
Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types Open
Cellular senescence is a driver of many age-related pathologies. There is an active search for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by targeting genes that promote the survival of senescent …
View article: Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB
Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB Open
Skeletal muscle mass and function can decline with aging, resulting in a syndrome known as sarcopenia. This decline is linked to functional alterations in critical cell types within mature muscle, including fibro-adipogenic progenitors (FA…
View article: Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence Open
Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which causes numerous morbidities and economic burdens in human populations. Mechanisms implicated in age-related sarcopenia include inflammation, muscle stem c…