Ryosuke Ikeguchi
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View article: Efficacy and safety of Bio 3D conduits composed of human umbilical cord–derived mesenchymal stromal cells: A proof-of-concept study in a canine ulnar nerve defect model
Efficacy and safety of Bio 3D conduits composed of human umbilical cord–derived mesenchymal stromal cells: A proof-of-concept study in a canine ulnar nerve defect model Open
Peripheral nerve injuries involving nerve defects remain challenging to treat. Although autologous nerve grafting is considered the gold standard, it has notable limitations, including donor site morbidity. To address this, we developed a …
View article: Characteristics of Skeletal Muscles in Lower Limb From the Perspective of Muscle Quality in Patients With Knee Osteoarthritis
Characteristics of Skeletal Muscles in Lower Limb From the Perspective of Muscle Quality in Patients With Knee Osteoarthritis Open
This observational cohort study aimed to comprehensively assess the muscle quality of gluteus, quadriceps femoris, and calf muscles. Seventy‐seven patients with knee osteoarthritis scheduled for total knee arthroplasty participated in this…
View article: Motor Recovery in Glioma Patients After Craniotomy: A Case Study of Continuous Rehabilitation Assessed With Diffusion Tensor Imaging
Motor Recovery in Glioma Patients After Craniotomy: A Case Study of Continuous Rehabilitation Assessed With Diffusion Tensor Imaging Open
Motor function deterioration is a common postoperative complication in glioma patients, affecting daily activities. Although continuous rehabilitation is essential for motor recovery, the underlying cause of postoperative decline remains u…
View article: Facial Nerve Regeneration in Immunodeficient Rats Using a Bio 3D Conduit Fabricated From Human Dental Pulp Stem Cells
Facial Nerve Regeneration in Immunodeficient Rats Using a Bio 3D Conduit Fabricated From Human Dental Pulp Stem Cells Open
Tumor surgery or trauma in the maxillofacial region may cause injuries to peripheral nerves, such as facial nerves. The gold standard of treatment for peripheral nerve injury has been autologous nerve grafting. Since new peripheral nerve r…
View article: The effect of KUS121, a novel VCP modulator, against ischemic injury in random pattern flaps
The effect of KUS121, a novel VCP modulator, against ischemic injury in random pattern flaps Open
Surgery using skin flaps is essential for soft tissue reconstruction. However, postoperative ischemic injury of the skin flap is a major complication and a top concern after the surgery. Currently, evidence-based drugs to fully prevent isc…
View article: Nerve regeneration using a Bio 3D conduit derived from umbilical cord–Derived mesenchymal stem cells in a rat sciatic nerve defect model
Nerve regeneration using a Bio 3D conduit derived from umbilical cord–Derived mesenchymal stem cells in a rat sciatic nerve defect model Open
Human umbilical cord–derived mesenchymal stromal cells (UC-MSCs), which can be prepared in advance and are presumed to be advantageous for nerve regeneration, have potential as a cell source for Bio 3D conduits. The purpose of this study w…
View article: Impact of Preoperative Skeletal Muscle Quality on Functional Outcome in Total Hip Arthroplasty
Impact of Preoperative Skeletal Muscle Quality on Functional Outcome in Total Hip Arthroplasty Open
Our results revealed that patients with a significantly higher IMAT prevalence and reduced NDM preoperatively were less likely to experience significant improvement after THA. Therefore, we propose that undergoing THA with good muscle qual…
View article: Fluctuation of physical function during chimeric antigen receptor T‐cell therapy during rehabilitation intervention: Real‐world data and risk factor analyses
Fluctuation of physical function during chimeric antigen receptor T‐cell therapy during rehabilitation intervention: Real‐world data and risk factor analyses Open
Introduction Patients undergoing chimeric antigen receptor (CAR) T‐cell therapy face prolonged treatment timelines and are prone to cytokine release syndrome (CRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) after in…
View article: Comparison of physical function recovery in patients with rheumatoid arthritis and those with osteoarthritis after total knee arthroplasty
Comparison of physical function recovery in patients with rheumatoid arthritis and those with osteoarthritis after total knee arthroplasty Open
Purpose: Patients with rheumatoid arthritis (RA) who have undergone primary total knee arthroplasty (TKA) have a different recovery process of walking ability compared with patients with osteoarthritis (OA). However, how this relates to pa…
View article: Fabrication of Artificial Nerve Conduits Used in a Long Nerve Gap: Current Reviews and Future Studies
Fabrication of Artificial Nerve Conduits Used in a Long Nerve Gap: Current Reviews and Future Studies Open
There are many commercially available artificial nerve conduits, used mostly to repair short gaps in sensory nerves. The stages of nerve regeneration in a nerve conduit are fibrin matrix formation between the nerve stumps joined to the con…
View article: A new method of the dynamic assessment of the supraspinatus using ultrasonography
A new method of the dynamic assessment of the supraspinatus using ultrasonography Open
Objective: We devised a new dynamic assessment of the supraspinatus (DAS) using ultrasonography. The objectives of this study are as follows: 1. to verify the moving distance of the supraspinatus using ultrasonography in the cadaveric shou…
View article: Treatment of Complete Brachial Plexus Injuries Using Double Free Muscle Transfer
Treatment of Complete Brachial Plexus Injuries Using Double Free Muscle Transfer Open
Therapeutic IV.
View article: Radiographic Evaluation after Arthroscopic Partial Trapeziectomy with Suture-button Suspensionplasty for Thumb Carpometacarpal Arthritis
Radiographic Evaluation after Arthroscopic Partial Trapeziectomy with Suture-button Suspensionplasty for Thumb Carpometacarpal Arthritis Open
Background: Arthroscopic partial trapeziectomy with suture-button suspensionplasty was developed for the surgical treatment of thumb carpometacarpal arthritis. However, the relationship between clinical results and radiographic evidence is…
View article: Investigation of treatment invasiveness from the terms of physical function in patients treated with Chimeric antigen receptor-T cell therapy
Investigation of treatment invasiveness from the terms of physical function in patients treated with Chimeric antigen receptor-T cell therapy Open
キメラ抗原受容体T(CAR-T)細胞療法患者の身体機能および治療侵襲度を検討した報告は少ない。そこでCAR-T細胞療法患者の治療前後の身体機能を定量的に評価し,CAR-T細胞療法の治療侵襲度を身体機能の側面より自家移植患者と比較し検討した。2014年から2022年に当院でびまん性大細胞型B細胞リンパ腫,多発性骨髄腫に対してCAR-T細胞療法および自家移植目的で入院した58人を対象とした。CAR-T細胞療法患者では,治療後においてサイトカイン放出症候群(CRS)を26人中23…
View article: Correlation between brain functional connectivity and neurocognitive function in patients with left frontal glioma
Correlation between brain functional connectivity and neurocognitive function in patients with left frontal glioma Open
The association between neurocognitive function (NCF) impairment and brain cortical functional connectivity in glioma patients remains unclear. The correlations between brain oscillatory activity or functional connectivity and NCF measured…
View article: Intramuscular Adipose Tissue Content Predicts Patient Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation
Intramuscular Adipose Tissue Content Predicts Patient Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation Open
During clinical courses involving treatment with allogeneic hematopoietic stem cell transplantation (allo-HSCT), multidisciplinary patient assessment including physical function is indispensable, and quantitative skeletal muscle loss is a …
View article: A First View of the Effect of a Trial of Early Mobilization on the Muscle Strength and Activities of Daily Living in Mechanically Ventilated Patients With COVID-19
A First View of the Effect of a Trial of Early Mobilization on the Muscle Strength and Activities of Daily Living in Mechanically Ventilated Patients With COVID-19 Open
This small sample size study found no difference in the functional recovery of patients with severe COVID-19 who underwent early mobilization under mechanical ventilation relative to when it was begun after extubation.
View article: First in-human trial protocol investigating a scaffold-free Bio 3D conduit developed from autologous dermal fibroblasts for peripheral nerve regeneration: a safety and feasibility study
First in-human trial protocol investigating a scaffold-free Bio 3D conduit developed from autologous dermal fibroblasts for peripheral nerve regeneration: a safety and feasibility study Open
Background Autologous nerve grafting is considered to be the gold standard treatment for severe and/or wide-ranging damage resulting in neurotmesis. However, the technique has several disadvantages including donor site morbidity and the li…
View article: Increased Brain Functional Connectivity Correlated With Neurocognitive Performance Decline in Patients With Left Frontal Glioma
Increased Brain Functional Connectivity Correlated With Neurocognitive Performance Decline in Patients With Left Frontal Glioma Open
Objectives: The association between neurocognitive decline and changing functional connectivity in glioma patients remains unclear. This study aimed to investigate the correlation between brain oscillatory activity or functional connectivi…
View article: Enthesopathy of the bicipital tuberosity of the radius treated under intraoperative computed tomography
Enthesopathy of the bicipital tuberosity of the radius treated under intraoperative computed tomography Open
Background There is no report of the application of intraoperative computed tomography to the extremities, and its usefulness is not mentioned. Case presentation We present a case of a patient with the elbow pain and loss of the forearm ro…
View article: Clinical Results of Arthroscopic Partial Trapeziectomy With Suture-Button Suspensionplasty for Thumb Carpometacarpal Arthritis
Clinical Results of Arthroscopic Partial Trapeziectomy With Suture-Button Suspensionplasty for Thumb Carpometacarpal Arthritis Open
Background: This study represents the clinical results, especially range of motion (ROM) improvement, of arthroscopic partial trapeziectomy with suture-button suspensionplasty for symptomatic grade II and III thumb carpometacarpal arthriti…
View article: Effect of a Rehabilitation Program After Mesenchymal Stromal Cell Transplantation for Advanced Osteonecrosis of the Femoral Head: A 10-Year Follow-Up Study
Effect of a Rehabilitation Program After Mesenchymal Stromal Cell Transplantation for Advanced Osteonecrosis of the Femoral Head: A 10-Year Follow-Up Study Open
The 12-week rehabilitation program and annual follow-up after mesenchymal stromal cell transplantation for osteonecrosis of the femoral head was associated with pain reduction, maintaining hip muscle strength, widening range of motion, and…
View article: Development of the Perfect O Sign Quantification Tool
Development of the Perfect O Sign Quantification Tool Open
Objective: The perfect O sign is often evaluated in carpal tunnel syndrome but there are no clear criteria. The purpose of this study is to develop a tool for quantifying the perfect O sign and to investigate the values of the perfect O si…