Ryosuke Ishida
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View article: Development of selective RyR2 inhibitors with a pharmacophore containing a parabanic acid skeleton
Development of selective RyR2 inhibitors with a pharmacophore containing a parabanic acid skeleton Open
Novel RyR2 inhibitor with a parabanic acid core was found by the screening. A comprehensive structure-activity relationship study led to over 15-fold better inhibitor 18, which inhibited not only WT RyR2 but also pathogenic mutated RyR2s.
View article: A novel RyR2-selective stabilizer prevents stress-induced ventricular arrhythmias without impairing cardiac function
A novel RyR2-selective stabilizer prevents stress-induced ventricular arrhythmias without impairing cardiac function Open
Background and Purpose Aberrant activation of the type 2 ryanodine receptor (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be …
View article: Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan Open
Background/Aims: Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging …
View article: Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor
Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor Open
Ryanodine receptor 2 (RyR2) is a large Ca2+-release channel in the sarcoplasmic reticulum (SR) of cardiac muscle cells. It serves to release Ca2+ from the SR into the cytosol to initiate muscle contraction. RyR2 overactivation is associate…
View article: Randomised controlled, patient-blinded, multicentre, superiority trial to evaluate the efficacy of the line-attached sheath-type traction device for endoscopic submucosal dissection in patients with superficial gastric neoplasms
Randomised controlled, patient-blinded, multicentre, superiority trial to evaluate the efficacy of the line-attached sheath-type traction device for endoscopic submucosal dissection in patients with superficial gastric neoplasms Open
Introduction EndoTrac is a line-attached sheath-type traction device that enables us to control the direction and the force of traction during endoscopic submucosal dissection (ESD). The efficacy of EndoTrac for gastric ESD has not been fu…
View article: CCDC 2283636: Experimental Crystal Structure Determination
CCDC 2283636: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring
Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring Open
Type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic (ER)/sarcoplasmic reticulum that plays a central role in the excitation-contraction coupling in the heart. Hyperactivity of RyR2 has been linked to ventricular a…
View article: Screening for novel RyR2 inhibitors by ER Ca<sup>2+</sup>monitoring
Screening for novel RyR2 inhibitors by ER Ca<sup>2+</sup>monitoring Open
Type 2 ryanodine receptor (RyR2) is a Ca 2+ release channel on the endoplasmic/sarcoplasmic reticulum (ER/SR) that plays a central role in the excitation-contraction coupling in the heart. Hyperactivity of RyR2 has been linked to ventricul…
View article: A novel strategy facilitating endoscopic submucosal dissection of proximal colonic lesions: the rubber band and sheath method
A novel strategy facilitating endoscopic submucosal dissection of proximal colonic lesions: the rubber band and sheath method Open
A 70-year-old woman was referred to our hospital for the treatment of a laterally spreading tumor in the ascending colon ([Fig. 1]). Endoscopic submucosal dissection (ESD) was performed using a novel strategy with an orthodontic elastic ru…
View article: Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration
Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration Open
All-trans-retinoic Acid (atRA) is the principal active metabolite of Vitamin A, essential for various biological processes. The activities of atRA are mediated by nuclear RA receptors (RARs) to alter gene expression (canonical activities) …
View article: Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes
Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes Open
Type 1 ryanodine receptor (RYR1) is a Ca2+ release channel in the sarcoplasmic reticulum (SR) of the skeletal muscle and plays a critical role in excitation–contraction coupling. Mutations in RYR1 cause severe muscle diseases, such as mali…
View article: Smile and speech for screening Parkinson’s disease and cognitive decline: A crowdsourced cross-sectional study
Smile and speech for screening Parkinson’s disease and cognitive decline: A crowdsourced cross-sectional study Open
Smiling and speech are typically disturbed in patients with Parkinson’s disease (PD). This study aimed to find a subset of smile and speech features suitable for identifying PD and cognitive decline to build predictive models. This crowdso…
View article: A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery Open
In skeletal muscle excitation–contraction (E–C) coupling, depolarization of the plasma membrane triggers Ca2+ release from the sarcoplasmic reticulum (SR), referred to as depolarization-induced Ca2+ release (DICR). DICR occurs through the …
View article: Reconstituted depolarization-induced Ca<sup>2+</sup>release platform for skeletal muscle disease mutation validation and drug discovery
Reconstituted depolarization-induced Ca<sup>2+</sup>release platform for skeletal muscle disease mutation validation and drug discovery Open
In skeletal muscle excitation-contraction (E-C) coupling, depolarization of the plasma membrane triggers Ca 2+ release from the sarcoplasmic reticulum (SR), referred to as depolarization-induced Ca 2+ release (DICR). DICR occurs via the ty…
View article: Establishment of reconstituted depolarization-induced Ca<sup>2+</sup> release platform for drug discovery of skeletal muscle diseases
Establishment of reconstituted depolarization-induced Ca<sup>2+</sup> release platform for drug discovery of skeletal muscle diseases Open
In skeletal muscle, depolarization of the plasma membrane triggers Ca2+ release from the sarcoplasmic reticulum (SR),referred to as depolarization-induced Ca2+ release (DICR). DICR occurs via the type 1 ryanodine receptor (RyR1), which phy…
View article: Temporal Contribution of Myeloid-Lineage TLR4 to the Transition to Chronic Pain: A Focus on Sex Differences
Temporal Contribution of Myeloid-Lineage TLR4 to the Transition to Chronic Pain: A Focus on Sex Differences Open
Complex regional pain syndrome (CRPS) is a chronic pain disorder with a clear acute-to-chronic transition. Preclinical studies demonstrate that toll-like receptor 4 (TLR4), expressed by myeloid-lineage cells, astrocytes, and neurons, media…
View article: Correction to: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation
Correction to: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation Open
A correction to this paper has been published: https://doi.org/10.1007/s11418-021-01499-w
View article: Modeling Complex Orthopedic Trauma in Rodents: Bone, Muscle and Nerve Injury and Healing
Modeling Complex Orthopedic Trauma in Rodents: Bone, Muscle and Nerve Injury and Healing Open
Orthopedic injury can occur from a variety of causes including motor vehicle collision, battlefield injuries or even falls from standing. Persistent limb pain is common after orthopedic injury or surgery and presents a unique challenge, as…
View article: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation
Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation Open
The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells ad…
View article: Structure–Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge
Structure–Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge Open
The tumor microenvironment is considered as one of the important targets for anticancer drug discovery. In particular, nutrient deficiency may be observed in tumor microenvironment; biakamides A-D (1-4) isolated from marine sponge Petrosas…