Rei Ono
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View article: Association of physical activity and hydration markers with cellular health in older adults: A doubly labeled water study
Association of physical activity and hydration markers with cellular health in older adults: A doubly labeled water study Open
PAL, measured using the precise DLW method, is an explanatory factor for PhA and ECW/ICW ratio. HLPA below the MVPA threshold was linked to more favorable hydration markers of cellular health in older adults. As this was a cross-sectional …
View article: Peritoneal Dialysis-Related Peritonitis Caused by Staphylococcus caprae: A Case Report.
Peritoneal Dialysis-Related Peritonitis Caused by Staphylococcus caprae: A Case Report. Open
Herein, we report a case of peritoneal dialysis (PD)-related peritonitis caused by Staphylococcus caprae (S. caprae). An 88-year-old man who had been receiving PD presented with cloudy effluent and an elevated dialysate white blood cell (W…
View article: Effect of short-term dietary intervention on fecal serotonin, gut microbiome-derived tryptophanase, and energy absorption in a randomized crossover trial: an exploratory analysis
Effect of short-term dietary intervention on fecal serotonin, gut microbiome-derived tryptophanase, and energy absorption in a randomized crossover trial: an exploratory analysis Open
In this study, we investigated the effects of short-term energy loads on changes in gut microbiome-derived tryptophanase and fecal serotonin levels and their association with variations in energy absorption. This randomized crossover energ…
View article: Changes in Step-Defined Physical Activity by Occupation: The National Health and Nutrition Survey of Japan 2001–2019
Changes in Step-Defined Physical Activity by Occupation: The National Health and Nutrition Survey of Japan 2001–2019 Open
Background : Accumulating more steps/day provides considerable health benefits; however, studies of steps/day trends among a working population are quite limited. Moreover, steps/day trends may differ among occupations. We aimed to assess …
View article: Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration
Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration Open
Emerging evidence has established neuroinflammation as a primary driver of progressive neuronal loss observed across neurodegenerative diseases (NDDs). The NLRP3 inflammasome is a cytosolic immunoprotective danger sensing complex, which wh…
View article: Association between preoperative grip strength and postoperative upper extremity impairments in patients with breast cancer: a retrospective cohort study
Association between preoperative grip strength and postoperative upper extremity impairments in patients with breast cancer: a retrospective cohort study Open
Background Upper extremity impairments in patients with breast cancer persist after curative surgery. Although postoperative factors associated with upper extremity impairments have been reported, modifiable factors affecting these impairm…
View article: Monocyte-derived Langerhans cells express Delta-like 4 induced by peptidoglycan and interleukin-4 mediated suppression
Monocyte-derived Langerhans cells express Delta-like 4 induced by peptidoglycan and interleukin-4 mediated suppression Open
T cells contribute to immunotherapy and autoimmune pathogenesis and Langerhans cells (LCs) have a substantial ability to activate T cells. In vitro -generated monocyte-derived LCs (Mo-LCs) are useful models to study LC function in autoimmu…
View article: Step-Determined Physical Activity among Individuals with Chronic Conditions: The 2007-2019 National Health and Nutrition Survey of Japan
Step-Determined Physical Activity among Individuals with Chronic Conditions: The 2007-2019 National Health and Nutrition Survey of Japan Open
Despite physical activity recommendations by clinical guidelines, steps/day in individuals with CCs were very low. More than half of individuals with CCs did not meet the physical activity guideline targets, even for those who reported eng…
View article: Relationship Between the 25-Question Geriatric Locomotive Function Scale and Falls: A One-Year Longitudinal Observational Study of 1,173 Healthy Community-Dwelling Residents Aged 65 and Older
Relationship Between the 25-Question Geriatric Locomotive Function Scale and Falls: A One-Year Longitudinal Observational Study of 1,173 Healthy Community-Dwelling Residents Aged 65 and Older Open
Introduction This study aimed to explore the relationship between the 25-question Geriatric Locomotive Function Scale (GLFS-25) score (i.e., total score and domain scores) and falls (i.e., history with or without falls and frequency of fal…
View article: Clinical characteristics of individuals stratified by the number of answered items on the 25-question Geriatric Locomotive Function Scale.
Clinical characteristics of individuals stratified by the number of answered items on the 25-question Geriatric Locomotive Function Scale. Open
The 25-question Geriatric Locomotive Function Scale (GLFS-25) is a tool to identify locomotive syndrome, however, this tool is associated with the problem of a low complete response rate. We conducted this cross-sectional study of 2,474 co…
View article: Effect of Centrality on Physical Activity in Late Childhood: A 1-Year Prospective Cohort Study
Effect of Centrality on Physical Activity in Late Childhood: A 1-Year Prospective Cohort Study Open
Background/Objectives: Engaging in physical activity (PA) is crucial for children’s physical and mental health, with PA in childhood influencing lifelong activity levels. However, PA during childhood tends to decrease with age. Childhood f…
View article: An 18‐month multimodal intervention trial for preventing dementia: J‐MINT PRIME Tamba
An 18‐month multimodal intervention trial for preventing dementia: J‐MINT PRIME Tamba Open
BACKGROUND The number of people with dementia is increasing in Japan, and establishing evidence for preventing dementia is necessary. METHODS This study was a randomized controlled trial in cognitively normal community‐dwelling older adult…
View article: Radiographic Knee Osteoarthritis Is a Risk Factor for the Development of Dementia: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study
Radiographic Knee Osteoarthritis Is a Risk Factor for the Development of Dementia: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study Open
Objective: Osteoarthritis is linked to dementia, but no longitudinal studies have established this connection. This prospective cohort study from the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) aimed to determine if…
View article: Morning physical activity may be more beneficial for blood lipids than afternoon physical activity in older adults: a cross-sectional study
Morning physical activity may be more beneficial for blood lipids than afternoon physical activity in older adults: a cross-sectional study Open
Background The effect of differences in daily physical activity patterns on blood lipids has not been determined. This study examines the effects of the differences in free-living daily physical activity patterns (amount and intensity) on …
View article: Predictors of Water Turnover in Older Adults: A Doubly Labeled Water- and Triaxial Accelerometer-Based Study
Predictors of Water Turnover in Older Adults: A Doubly Labeled Water- and Triaxial Accelerometer-Based Study Open
Our results confirmed that age, sex, weight, FFM, TEE, and PAL are the potential predictors of WT in older Japanese adults aged ≥65 y.
View article: Behavioral and Psychological Symptoms of Dementia and Mortality Risk Among People With Cognitive Impairment: An 8-year Longitudinal Study From the NCGG-STORIES
Behavioral and Psychological Symptoms of Dementia and Mortality Risk Among People With Cognitive Impairment: An 8-year Longitudinal Study From the NCGG-STORIES Open
The findings suggest a potential association between BPSD and poor prognosis among males with cognitive impairment.
View article: Factors Influencing Life Space Mobility in Cancer Survivors Following Hematopoietic Stem Cell Transplantation - Physical Function, Depression, Fatigue, Neighborhood Walkability, and Employment Status
Factors Influencing Life Space Mobility in Cancer Survivors Following Hematopoietic Stem Cell Transplantation - Physical Function, Depression, Fatigue, Neighborhood Walkability, and Employment Status Open
Background/objective: The level of physical activity in the daily lives of cancer survivors following hematopoietic stem cell transplantation (HSCT) is crucial for maintaining their physical and mental health. Considering that life space m…
View article: Impact of type 2 diabetes and glycated hemoglobin levels within the recommended target range on mortality in older adults with cognitive impairment receiving care at a memory clinic: NCGG-STORIES
Impact of type 2 diabetes and glycated hemoglobin levels within the recommended target range on mortality in older adults with cognitive impairment receiving care at a memory clinic: NCGG-STORIES Open
Objective: To determine the impact of type 2 diabetes and glycated hemoglobin (HbA1c) levels within the recommended target range according to the Japan Diabetes Society/Japan Geriatrics Society Joint Committee on mortality in older adults …
View article: Impact of type 2 diabetes and glycated hemoglobin levels within the recommended target range on mortality in older adults with cognitive impairment receiving care at a memory clinic: NCGG-STORIES
Impact of type 2 diabetes and glycated hemoglobin levels within the recommended target range on mortality in older adults with cognitive impairment receiving care at a memory clinic: NCGG-STORIES Open
Objective: To determine the impact of type 2 diabetes and glycated hemoglobin (HbA1c) levels within the recommended target range according to the Japan Diabetes Society/Japan Geriatrics Society Joint Committee on mortality in older adults …
View article: Impact of Concurrent Visual and Hearing Impairment on Incident Alzheimer’s Disease: The LIFE Study
Impact of Concurrent Visual and Hearing Impairment on Incident Alzheimer’s Disease: The LIFE Study Open
Background: The prevalence of Alzheimer’s disease (AD) is increasing in Japan due to population aging. The association between sensory impairment and incident AD remains unclear. Objective: This study aimed to investigate the impact of sen…
View article: Association between abdominal adiposity and cognitive decline in older adults: a 10-year community-based study
Association between abdominal adiposity and cognitive decline in older adults: a 10-year community-based study Open
Higher WC, SFA, and VFA in men and higher WC and SFA in women were identified as risk factors for cognitive decline in later life, suggesting that abdominal adiposity involved in cognitive decline may differ according to sex.
View article: Association between regular physical activity and pneumonia-related hospitalization according to pneumococcal vaccination status: The VENUS study
Association between regular physical activity and pneumonia-related hospitalization according to pneumococcal vaccination status: The VENUS study Open
PA can reduce the risk of pneumonia-related hospitalization in vaccinated persons. Interventions that increase both vaccination rates and PA habits may help to reduce these hospitalizations in older adults.
View article: Data resource profile: Exercise habits, step counts, and sedentary behavior from the National Health and Nutrition Survey in Japan
Data resource profile: Exercise habits, step counts, and sedentary behavior from the National Health and Nutrition Survey in Japan Open
The National Health and Nutrition Survey consistently assesses the prevalence of exercise habits, step counts, and sedentary behaviors in a strategically selected random sample of the Japanese population. The aim of this study was to provi…
View article: Relationship between mortality and vitality in patients with mild cognitive impairment/dementia: An 8‐year retrospective study
Relationship between mortality and vitality in patients with mild cognitive impairment/dementia: An 8‐year retrospective study Open
Aim The study aimed to investigate the association of vitality, as measured using the vitality index (Vix), with the survival outcomes of older adults with mild cognitive impairment (MCI) or dementia. Methods We analyzed data from 3731 pat…
View article: Pneumococcal vaccination coverage and vaccination-related factors among older adults in Japan: LIFE Study
Pneumococcal vaccination coverage and vaccination-related factors among older adults in Japan: LIFE Study Open
Individual factors, such as sex and Specific Health Check-ups participation, were found to be important factors affecting pneumococcal vaccination among older adults in Japan. Environmental factors, such as the characteristics of residenti…