Ryuji Ikeda
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View article: Pharmacist support in the entry of blood drug concentration test order avoids vancomycin-induced kidney injury
Pharmacist support in the entry of blood drug concentration test order avoids vancomycin-induced kidney injury Open
Background: Task shifting and sharing have been proposed as strategies to address healthcare staffing shortages and improve patient outcomes. In emergency and intensive care medicine, pharmacist interventions have shown potential to reduce…
View article: Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis
Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis Open
Intra-patient variability in immunosuppressive blood drug concentrations is a potential biomarker in managing organ transplant patients. However, the association between the time in therapeutic range of tacrolimus blood concentrations and …
View article: Characteristics of psychiatric patients with nightmares after suvorexant administration: A retrospective study
Characteristics of psychiatric patients with nightmares after suvorexant administration: A retrospective study Open
Aim Suvorexant is an orexin receptor antagonist (ORA) for the treatment of insomnia. The antagonistic action of suvorexant on orexin receptors is associated with an increase in rapid eye movement (REM) sleep, which can potentially lead to …
View article: Development of Dose Calculation Application for Computed Tomography Dose Management When Facility Protocols Differ from Diagnostic Reference Level (DRL)
Development of Dose Calculation Application for Computed Tomography Dose Management When Facility Protocols Differ from Diagnostic Reference Level (DRL) Open
By calculating dose values that align with DRL conditions, our application contributes to the implementation and optimization of dose management in CT for facilities that use diverse imaging protocols.
View article: Development of an automated region-of-interest-setting method based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods.
Development of an automated region-of-interest-setting method based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods. Open
New ROI- setting programs were developed using a deep convolution neural network DCNN to determine the input functions for the SIMS and IBUR methods. The accuracy of these methods is comparable to that of the manual method.
View article: Feasibility of direct brain <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography attenuation and high-resolution correction methods using deep learning.
Feasibility of direct brain <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography attenuation and high-resolution correction methods using deep learning. Open
The direct+HRC method enables accurate attenuation without CT exposure and high-resolution correction without dedicated correction programs.
View article: Influence of Endogenous Substances on Site-II to Site-I Displacement of Diclofenac Bound to Albumin in the Aqueous Humor of Patients with Cataract
Influence of Endogenous Substances on Site-II to Site-I Displacement of Diclofenac Bound to Albumin in the Aqueous Humor of Patients with Cataract Open
Diclofenac instillation is useful in preventing intraoperative miosis and macular edema caused by postoperative inflammation in cataract surgery; however, optimum efficacy is not attained when the instilled diclofenac strongly binds to alb…
View article: Development of an automated region-of-interest-setting program based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods
Development of an automated region-of-interest-setting program based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods Open
A simple noninvasive microsphere (SIMS) method using 123I-IMP and an improved brain uptake ratio (IBUR) method using 99mTc-ECD for the quantitative measurement of regional cerebral blood flow have been recently reported. The input function…
View article: Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment Open
Background Niemann–Pick disease type C (NPC) is a fatal neurodegenerative disorder caused by abnormal intracellular cholesterol trafficking. Cyclodextrins (CDs), the most promising therapeutic candidates for NPC, but with concerns about ot…
View article: Supplementary Table 1 from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil
Supplementary Table 1 from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil Open
Supplementary Table 1 from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil
View article: Data from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil
Data from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil Open
5-Fluorouracil (5-FU) is one of the most commonly used anticancer drugs in chemotherapy against various solid tumors. 5-FU dose-dependently increased the expression levels of intrinsic antiangiogenic factor thrombospondin-1 (TSP-1) in huma…
View article: Supplementary Table 1 from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Supplementary Table 1 from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
Supplementary Table 1 from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
View article: Supplementary Figure 1B from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Supplementary Figure 1B from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
Supplementary Figure 1B from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
View article: Data from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Data from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
We and others have shown that the copper transporters ATP7A and ATP7B play a role in cellular resistance to cis-diaminedichloroplatinum (II) (CDDP). In this study, we found that ATP7A transfection of Chinese hamster ovary cells (CHO-K1) an…
View article: Data from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Data from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
We and others have shown that the copper transporters ATP7A and ATP7B play a role in cellular resistance to cis-diaminedichloroplatinum (II) (CDDP). In this study, we found that ATP7A transfection of Chinese hamster ovary cells (CHO-K1) an…
View article: Supplementary Figure 1B from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Supplementary Figure 1B from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
Supplementary Figure 1B from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
View article: Supplementary Table 1 from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Supplementary Table 1 from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
Supplementary Table 1 from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
View article: Data from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil
Data from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil Open
5-Fluorouracil (5-FU) is one of the most commonly used anticancer drugs in chemotherapy against various solid tumors. 5-FU dose-dependently increased the expression levels of intrinsic antiangiogenic factor thrombospondin-1 (TSP-1) in huma…
View article: Supplementary Figure 1A from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Supplementary Figure 1A from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
Supplementary Figure 1A from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
View article: Supplementary Figure 1A from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Supplementary Figure 1A from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer Open
Supplementary Figure 1A from Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
View article: Supplementary Table 1 from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil
Supplementary Table 1 from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil Open
Supplementary Table 1 from Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil
View article: Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study
Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study Open
Aim Yokukansan is a Japanese herbal medicine used in psychiatry to treat behavioral and psychological symptoms of dementia and other psychiatric symptoms. However, the glycyrrhizic acid included in this medicine can cause pseudoaldosteroni…
View article: Feasibility of Deep Convolution Neural Network-Based Automatic Time Activity Curve Fitting Method for Non-Invasive Cerebral Blood Flow Quantification
Feasibility of Deep Convolution Neural Network-Based Automatic Time Activity Curve Fitting Method for Non-Invasive Cerebral Blood Flow Quantification Open
In this study, we aimed to develop a deep convolutional neural network (DCNN)-based automatic time-activity curve (TAC) fitting method for input function determination. This will be achieved through a comparison between the DCNN method, ma…
View article: Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann–Pick disease type C without hearing loss
Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann–Pick disease type C without hearing loss Open
Niemann-Pick disease type C (NPC) is a fatal disorder with abnormal intracellular cholesterol trafficking resulting in neurodegeneration and hepatosplenomegaly. A cyclic heptasaccharide with different degrees of substitution of 2-hydroxypr…
View article: Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells
Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells Open
Aberrant activation of hepatocyte growth factor (HGF) and its receptor c-Met axis promotes tumor growth. Therefore, many clinical trials have been conducted. A phase 3 trial investigating a monoclonal antibody targeting HGF in combination …
View article: Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity
Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity Open
Background Cardiac troponin-T ( TNNT2 ) is exclusively present in cardiac muscle. Measurement of TNNT2 is used for diagnosing acute coronary syndrome. However, its expression may not be limited in myocardium. This study aimed at evaluating…
View article: Correction of Partial Volume Effect Using CT Images in Brain <sup>18</sup>F-FDG PET
Correction of Partial Volume Effect Using CT Images in Brain <sup>18</sup>F-FDG PET Open
It is suggested that the correction by CT can be performed with the same accuracy, although some errors are generated compared with MRI.