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View article: α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages
α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages Open
Sepsis-induced acute kidney injury (AKI) is associated with a high mortality rate and presents a significant clinical challenge. However, effective treatment measures have not yet been established. The cholinergic anti-inflammatory pathway…
View article: Macrophage depletion lowers blood pressure and reduces renal fibrosis progression in existing hypertension mice model
Macrophage depletion lowers blood pressure and reduces renal fibrosis progression in existing hypertension mice model Open
Uncontrolled hypertension is a global health issue with 40 % of hypertensive patients not achieving blood pressure control with current therapies. Previously, we demonstrated renal macrophage infiltration during hypertension development wi…
View article: Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation
Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation Open
Psychological stress diminishes the efferocytotic capacity of PD-L2-positive macrophages, causing an accumulation of dead cells. This, in turn, heightens eosinophil infiltration through Caspase-1-dependent production of CCL24, exacerbating…
View article: Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury
Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury Open
Acute kidney injury (AKI), a serious disease for which there is no effective Federal Drug Administration-approved treatment, is associated with high mortality rates. Bone marrow stromal cell antigen-1 (Bst1) is a cell surface molecule that…
View article: Bone marrow stromal cell antigen-1 (CD157) regulated by sphingosine kinase 2 mediates kidney fibrosis
Bone marrow stromal cell antigen-1 (CD157) regulated by sphingosine kinase 2 mediates kidney fibrosis Open
Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.…
View article: Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency
Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency Open