Marina Ryzhova
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View article: P10.17.B IMPACT OF SOMATIC TP53 MUTATION ON SURVIVAL OF PATIENTS WITH MEDULLOBLASTOMA OF THE WNT MOLECULAR GROUP
P10.17.B IMPACT OF SOMATIC TP53 MUTATION ON SURVIVAL OF PATIENTS WITH MEDULLOBLASTOMA OF THE WNT MOLECULAR GROUP Open
RELEVANCE The WNT molecular group (MB-WNT) constitutes only 10% of medulloblastoma cases. This group is characterized by a favorable prognosis. Considering the aggressive schemes used in the treatment for medulloblastoma, it seems appropri…
View article: P10.06.A PROGNOSTIC FACTORS IN CHILDREN WITH SHH MEDULLOBLASTOMA.
P10.06.A PROGNOSTIC FACTORS IN CHILDREN WITH SHH MEDULLOBLASTOMA. Open
RELEVANCE Medulloblastomas of the SHH account for 30% of all medulloblastomas in children and are a heterogeneous group in the histological and molecular landscape. The prognosis of the disease depends on many factors. OBJECTIVE To evaluat…
View article: The phenomenon of long-term survival of patients with supratentorial glioblastomas: features of complex treatment and neuroimaging data
The phenomenon of long-term survival of patients with supratentorial glioblastomas: features of complex treatment and neuroimaging data Open
Background. Glioblastoma is the most common primary malignant brain tumor with an extremely unfavorable prognosis. The frequency of the “longevity” phenomenon (>3 years of overall survival – OS) in this disease is 5–10 %. The reasons for t…
View article: A modern view of the phenomenon of trilateral retinoblastoma from the positions of ophthalmic oncology and neurooncology. Part I. Literature review
A modern view of the phenomenon of trilateral retinoblastoma from the positions of ophthalmic oncology and neurooncology. Part I. Literature review Open
Trilateral retinoblastoma (TRb) phenomenon is a combination of bilateral retinoblastoma (Rb) (in most cases) and molecular group A pineoblastoma (Pb). The study of this phenomenon has been going on for more than 30 years, is interdisciplin…
View article: Metronomic chemotherapy in pediatric neurooncology: insight the problem. A review
Metronomic chemotherapy in pediatric neurooncology: insight the problem. A review Open
Metronomic chemotherapy (MCT) is a promising direction of anticancer therapy, as well as in pediatric oncology, and its administration in patients with refractory and recurrent tumors of the central nervous system becomes increasingly rele…
View article: NFS-26.<i>RB1</i>-ALTERED SUBTYPE (GROUP A) PINEOBLASTOMA AS A PART OF «TRILATERAL RETINOBLASTOMA» PHENOMENON: NEURO-ONCOLOGICAL AND OPHTHALMIC-ONCOLOGICAL VIEW
NFS-26.<i>RB1</i>-ALTERED SUBTYPE (GROUP A) PINEOBLASTOMA AS A PART OF «TRILATERAL RETINOBLASTOMA» PHENOMENON: NEURO-ONCOLOGICAL AND OPHTHALMIC-ONCOLOGICAL VIEW Open
BACKGROUND RB1-altered subtype (Group A) pineoblastoma as a part of «Trilateral retinoblastoma» is an extremely rare phenomenon. But over the past 10 years, the incidence of this disease has been increasing. Optimal therapeutic strategy is…
View article: Experience of like-SJMB03 protocolin treatment of children with medulloblastomain the age group over 3 years:results of an intercenter pilot study
Experience of like-SJMB03 protocolin treatment of children with medulloblastomain the age group over 3 years:results of an intercenter pilot study Open
Background. The experience of using the like-SJMB03 therapeutic program is presented. The aim of this study was to assess the potential possibility of reducing the dose of craniospinal and local radiation therapy in the standard and high-r…
View article: The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration
The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration Open
High-grade gliomas are considered an incurable disease. Despite all the various therapy options available, patient survival remains low, and the tumor usually returns. Tumor resistance to conventional therapy and stimulation of the migrato…
View article: International experience by using of the SJMB protocols in treatment of children with medulloblastoma in the age group over 3 years (literature review)
International experience by using of the SJMB protocols in treatment of children with medulloblastoma in the age group over 3 years (literature review) Open
During the last 30 years, unique international experience has been accumulated in the treatment of children with medulloblastoma, especially in the age group over 3 years. Evolutionary representations about one of the most well – known int…
View article: Results of a multicenter study of the treatment of WNT medulloblastomas in children
Results of a multicenter study of the treatment of WNT medulloblastomas in children Open
Medulloblastomas of the WNT molecular group (MB-WNT) represent the smallest group of MB and account for only 10 % of the total. This molecular group is characterized by a favorable prognosis. Given the aggressive treatment regimens for MB,…
View article: Analysis of DNA methylation profiles confirms a high proportion of immune cells in glioblastoma samples
Analysis of DNA methylation profiles confirms a high proportion of immune cells in glioblastoma samples Open
Glioblastomas are malignant tumors that belong to the central nervous system and are challenging to diagnose due to their significant intratumoral heterogeneity, which makes molecular testing and diagnosis confirmation particularly difficu…
View article: DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report Open
Central nervous system (CNS) tumors in children comprise a highly heterogenous and complex group of diseases. Historically, diagnosis and confirmation of these tumors were routinely based on histological examination. However, recently obta…
View article: The principles of therapy for modern diagnosis of brain tumors in children, which determine the prescription of the drugs
The principles of therapy for modern diagnosis of brain tumors in children, which determine the prescription of the drugs Open
Currently, the daily routine of a molecular pathologist is DNA methylation and RNA and DNA sequencing. The authors, from the standpoint of researchers and clinicians, explain the molecular methods used not only to diagnose brain tumors, bu…
View article: Principles of modern brain tumor diagnosis
Principles of modern brain tumor diagnosis Open
The paper reports methodology of the current phase of brain tumor recognition. The World Health Organization classification of the central nervous system tumors issued in 2021 and its main differences from the previous version are provided…
View article: Comparative treatment results of children with atypical teratoid/rhabdoid tumor of the central nervous system in the younger age group
Comparative treatment results of children with atypical teratoid/rhabdoid tumor of the central nervous system in the younger age group Open
Introduction. Atypical teratoid/rhabdoid tumor (ATRT) of the central nervous system (CNS) belongs to the embryonic group, occurs mainly in children under 3 years of age and is characterized by an extremely aggressive clinical course and un…
View article: Supplementary Table S5 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S5 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S5 - GO analysis for C11orf95-target models specific DEGs
View article: Supplementary Table S7 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S7 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S7 - Antibody list
View article: Supplementary Table S2 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S2 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S2 - Copy number alterations for all 613 tumors
View article: Supplementary Table S1 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S1 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S1 - A summary of the human cohort used for DNA methylation-profiling_DRG3003
View article: Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA–RELA or YAP1-involving fusions and fusion-negative subependymoma. However, occasionally supratentorial ependymomas cannot be readily assigned to any of these groups d…
View article: Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA–RELA or YAP1-involving fusions and fusion-negative subependymoma. However, occasionally supratentorial ependymomas cannot be readily assigned to any of these groups d…
View article: Supplementary Table S3 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S3 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S3 - Differentially expressed genes of ST-EPN-RELA and cluster 2 - 4
View article: Supplementary Table S3 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S3 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S3 - Differentially expressed genes of ST-EPN-RELA and cluster 2 - 4
View article: Supplementary Table S7 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S7 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S7 - Antibody list
View article: Supplementary Table S4 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S4 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S4 - Histopathological evaluation of 25 cases
View article: Supplementary Table S2 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S2 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S2 - Copy number alterations for all 613 tumors
View article: Supplementary Table S1 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S1 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S1 - A summary of the human cohort used for DNA methylation-profiling_DRG3003
View article: Supplementary Table S5 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S5 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S5 - GO analysis for C11orf95-target models specific DEGs
View article: Supplementary Table S6 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S6 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S6 - Primer list