Stanley A. Plotkin
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View article: Expert consensus on the benefits of neuraminidase in conventional influenza vaccines: a Delphi study
Expert consensus on the benefits of neuraminidase in conventional influenza vaccines: a Delphi study Open
NA is an important influenza vaccine component and is associated with specific benefits. These benefits would likely be greater if NA content were standardised. Additional research is needed to optimise vaccines for anti-NA effects.
View article: Realising the potential of correlates of protection for vaccine development, licensure and use: short summary
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary Open
View article: Enabling the evaluation of COVID-19 vaccines with correlates of protection
Enabling the evaluation of COVID-19 vaccines with correlates of protection Open
In February 2023, a meeting about correlates of protection (CoPs) against COVID-19 was organized by the International Alliance for Biological Standardization, the European Plotkin Institute for Vaccinology, and Vaccinopolis. The meeting ai…
View article: State-of-the-Science of human papillomavirus vaccination in women with human immunodeficiency Virus: Summary of a scientific workshop
State-of-the-Science of human papillomavirus vaccination in women with human immunodeficiency Virus: Summary of a scientific workshop Open
The burden of cervical cancer is disproportionately distributed globally, with the vast majority of cases occurring in low- and middle-income countries. Women with human immunodeficiency virus (HIV) (WWH) are at increased risk of human pap…
View article: Supp Figure Legends from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Supp Figure Legends from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy Open
Legends
View article: Supp Figures from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Supp Figures from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy Open
Supplemental Figure 1 - Rates of CIN2/3 regression (primary endpoint) or CIN2/3 regression concomitant with clearance of HPV16 and/or HPV18 infection (secondary endpoint) in the Per Protocol population of the Phase IIb study of VGX-3100 fo…
View article: Data from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Data from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy Open
Purpose: As previously reported, treatment of high-grade cervical dysplasia with VGX-3100 resulted in complete histopathologic regression (CR) concomitant with elimination of HPV16/18 infection in 40.0% of VGX-3100–treated patients …
View article: Supp Figures from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Supp Figures from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy Open
Supplemental Figure 1 - Rates of CIN2/3 regression (primary endpoint) or CIN2/3 regression concomitant with clearance of HPV16 and/or HPV18 infection (secondary endpoint) in the Per Protocol population of the Phase IIb study of VGX-3100 fo…
View article: Data from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Data from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy Open
Purpose: As previously reported, treatment of high-grade cervical dysplasia with VGX-3100 resulted in complete histopathologic regression (CR) concomitant with elimination of HPV16/18 infection in 40.0% of VGX-3100–treated patients …
View article: Supp Figure Legends from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Supp Figure Legends from Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy Open
Legends
View article: Vaccine Decision-making in a Time of Conflicting Recommendations: A Call to Go Beyond Politics
Vaccine Decision-making in a Time of Conflicting Recommendations: A Call to Go Beyond Politics Open
Salmon, Daniel A. PhD; Plotkin, Stanley MD; Navar, Ann Marie MD, PhD Author Information
View article: Recent updates on correlates of vaccine-induced protection
Recent updates on correlates of vaccine-induced protection Open
Correlates of protection are key for vaccine development against any pathogen. In this paper we summarize recent information about correlates for vaccines against dengue, Ebola, influenza, pneumococcal, respiratory syncytial virus, rotavir…
View article: A Covid-19 Milestone Attained — A Correlate of Protection for Vaccines
A Covid-19 Milestone Attained — A Correlate of Protection for Vaccines Open
View article: The world needs to prepare now to prevent polio resurgence post eradication
The world needs to prepare now to prevent polio resurgence post eradication Open
View article: Review of: "Lessons from vaccine-related poliovirus in Israel, UK and USA"
Review of: "Lessons from vaccine-related poliovirus in Israel, UK and USA" Open
a well known polio expert, and his associate Dr. Dharmapalan, have published a strong argument for a change in the strategy of polio eradication.Attempts to eradicate polio have been going on for the last 30 years using attenuated strains …
View article: Making more COVID-19 vaccines available to address global needs: Considerations and a framework for their evaluation
Making more COVID-19 vaccines available to address global needs: Considerations and a framework for their evaluation Open
View article: Why We Need Precision Vaccinology
Why We Need Precision Vaccinology Open
Vaccine development has moved from an empirical origin to the use of antigenic characterization, structural biology, immune function definition, protein synthesis, and precise definition of immune correlates of protection in order to deal …
View article: Serologic Tests for COVID-19 Infections and Vaccination
Serologic Tests for COVID-19 Infections and Vaccination Open
From the Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Pennsylvania, USA Accepted for publication April 23, 2022 The author has no funding or conflicts of interest to disclose. Address for corre…
View article: Correlates of protection against <scp>SARS</scp>‐<scp>CoV</scp>‐2 infection and COVID‐19 disease
Correlates of protection against <span>SARS</span>‐<span>CoV</span>‐2 infection and COVID‐19 disease Open
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers givi…
View article: Obituary of Robert Daum - Expert in Staphylococcal Disease
Obituary of Robert Daum - Expert in Staphylococcal Disease Open
View article: Precision Vaccines: Lessons Learned From the Coronavirus Pandemic
Precision Vaccines: Lessons Learned From the Coronavirus Pandemic Open
View article: Correlates of Protection Against SARS CoV-2 Infection and Covid 19 Disease
Correlates of Protection Against SARS CoV-2 Infection and Covid 19 Disease Open
Antibodies against epitopes in S1 of SARS-2 coronavirus give the most accurate correlate of protection against infection. Measurement of those antibodies by neutralization or binding assays have predictive value. However, the protective fu…
View article: The scourge of vaccine falsification
The scourge of vaccine falsification Open
View article: Evolving measles status and immunization policy development in six European countries
Evolving measles status and immunization policy development in six European countries Open
Developing and implementing new immunization policies in response to shifting epidemiology is a critical public health component. We adopted a mixed-methods approach (via narrative literature review [101 articles] and 9 semi-structured int…
View article: Towards a population-based threshold of protection for COVID-19 vaccines
Towards a population-based threshold of protection for COVID-19 vaccines Open
Correlates of protection for COVID-19 vaccines are urgently needed to license additional vaccines. We measured immune responses to four COVID-19 vaccines of proven efficacy using a single serological platform. IgG anti-Spike antibodies wer…
View article: The influence of interval between doses on response to vaccines
The influence of interval between doses on response to vaccines Open
View article: Polio eradication vaccine investment: how do we ensure polio vaccines are available to keep the world polio-free after transmission of wild poliovirus (wPV) has been interrupted?
Polio eradication vaccine investment: how do we ensure polio vaccines are available to keep the world polio-free after transmission of wild poliovirus (wPV) has been interrupted? Open
View article: NIAID workshop on secondary vaccine effects
NIAID workshop on secondary vaccine effects Open
View article: A Population-Based Threshold of Protection for COVID-19 Vaccines
A Population-Based Threshold of Protection for COVID-19 Vaccines Open
Correlates of protection for COVID-19 vaccines are urgently needed to license and deploy additional vaccines. We measured immune responses to four COVID-19 vaccines of proven efficacy using a single serological platform calibrated to the i…
View article: Evidence for antibody as a protective correlate for COVID-19 vaccines
Evidence for antibody as a protective correlate for COVID-19 vaccines Open