Seema A. Khan
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View article: Reprogramming <scp>SREBP1</scp> ‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention
Reprogramming <span>SREBP1</span> ‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention Open
Anti‐estrogens have had a limited impact on breast cancer (BC) prevention. Novel agents with better tolerability, and efficacy beyond estrogen receptor (ER) positive BC are needed. We studied licochalcone A (LicA) for ER‐agnostic BC preven…
View article: USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I
USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I Open
While immune checkpoint blockade (ICB) therapy has revolutionized the antitumor therapeutic landscape, it remains successful in only a small subset of patients with cancer. Poor or loss of MHC-I expression has been implicated as a common m…
View article: Radiotherapy With a 12-Gene Expression Assay for Ductal Carcinoma In Situ
Radiotherapy With a 12-Gene Expression Assay for Ductal Carcinoma In Situ Open
Importance Breast ductal carcinoma in situ (DCIS) requires personalized treatment given its variable natural history. This study reports the first prospective oncologic outcomes of radiotherapy decisions as guided by 12-gene molecular assa…
View article: Medium-Chain Fatty Acid exposure in non-transformed mammary glands leads to pro-tumorigenic alterations associated with aging
Medium-Chain Fatty Acid exposure in non-transformed mammary glands leads to pro-tumorigenic alterations associated with aging Open
The local breast environment is a valuable research focus for identifying the etiological and biological factors that contribute to the development of breast cancer. Single-cell RNA sequencing shows that the increased availability of the m…
View article: Data from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
Data from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels Open
Accumulation of the DNA adduct γ-hydroxy-1,N2-propanodeoxyguanosine (γ-OHPdG) is associated with hepatocellular carcinoma development. Theaphenon E—a green tea polyphenol extract dosed according to mg of epigallocatechin gallate—suppresses…
View article: Supplemental Table 2 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
Supplemental Table 2 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels Open
Supplemental Table 2: Adverse Events, N = 13 Participants
View article: Supplemental Methods 1 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
Supplemental Methods 1 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels Open
Supplemental Methods 1: Clinical Trial Protocol
View article: Supplemental Table 1 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
Supplemental Table 1 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels Open
Supplemental Table 1: Baseline Liver Characteristics by Dose Cohort, N = 13 Participants
View article: Supplemental Table 3 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
Supplemental Table 3 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels Open
Supplemental Table 3: Study Participants Representativeness Table
View article: Multiomic Analysis Links Neighborhood Disadvantage to Inflammatory Proteins and Tumorigenic Markers in ER+ Breast Cancer Plasma and Tumor Samples
Multiomic Analysis Links Neighborhood Disadvantage to Inflammatory Proteins and Tumorigenic Markers in ER+ Breast Cancer Plasma and Tumor Samples Open
Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor-positive (ER+) breast cancer (BC), yet the underlying multiomic alterations remain underexplored. To investigate associat…
View article: Quality of Life Among Patients With Ductal Carcinoma In Situ
Quality of Life Among Patients With Ductal Carcinoma In Situ Open
Importance Limited longitudinal data exist regarding health-related quality of life (HRQL) following surgery for ductal carcinoma in situ (DCIS) breast cancer. Objective To assess individual- and neighborhood-level factors associated with …
View article: A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels Open
Accumulation of the DNA adduct γ-hydroxy-1,N2-propanodeoxyguanosine (γ-OHPdG) is associated with hepatocellular carcinoma development. Theaphenon E—a green tea polyphenol extract dosed according to mg of epigallocatechin gallate—suppresses…
View article: DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls
DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls Open
DNA methylation profiles differ profoundly at two points: tumor to case-benign and case-benign to HDB, with clear distinction between ER + and ER- tumors. Case-benign tissues are not epigenetically "normal", are similar across both breasts…
View article: Table S2 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S2 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S2: Representativeness of Study Participants
View article: Figure S1 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Figure S1 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Figure S1: Participants' study medication adherence
View article: Table S5 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S5 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S5: Baseline participant characteristics (Evaluable participants vs non-evaluable participants)
View article: Table S6 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S6 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S6: Adverse events by treatment arms
View article: Table S3 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S3 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S3: Baseline participant characteristics (All participants)
View article: Table S7 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S7 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S7: Comparisons of pre- to post-treatment changes in methylation biomarkers CpG for continuous aspirin vs. intermittent aspirin arm
View article: Data from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Data from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Aspirin reduces colorectal cancer risk but has a potential for adverse effects. Recent preclinical data suggest that intermittent dosing of aspirin may minimize adverse effects while maintaining efficacy. We conducted a three-arm double-bl…
View article: Table S4 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S4 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S4: Baseline participant characteristics (Evaluable participants only)
View article: Table S1 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S1 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S1: Strain information for microbiome analysis
View article: Table S8 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Table S8 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Table S8 Comparisons of pre- (Week 0) to post-treatment (Week 9) changes in endpoint biomarkers for continuous aspirin vs. intermittent aspirin arm
View article: SREBP1-Dependent Metabolism as a Potential Target for Breast Cancer Risk Reduction
SREBP1-Dependent Metabolism as a Potential Target for Breast Cancer Risk Reduction Open
There are an estimated 10 million U [...]
View article: MRI-based Radiomic Features for Risk Stratification of Ductal Carcinoma in Situ in a Multicenter Setting (ECOG-ACRIN E4112 Trial)
MRI-based Radiomic Features for Risk Stratification of Ductal Carcinoma in Situ in a Multicenter Setting (ECOG-ACRIN E4112 Trial) Open
Models using clinical and MRI-based radiomic features identified from ductal carcinoma in situ lesions improved prediction of disease upstaging at surgery compared with standard clinical information alone.
View article: A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells Open
Lipid metabolism and the serine, one-carbon, glycine (SOG) and methionine pathways are independently and significantly correlated with estrogen receptor–negative breast cancer (ERneg BC). Here, we propose a link between lipid metabolism an…
View article: Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention
Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open
Aspirin reduces colorectal cancer risk but has a potential for adverse effects. Recent preclinical data suggest that intermittent dosing of aspirin may minimize adverse effects while maintaining efficacy. We conducted a three-arm double-bl…
View article: Neoadjuvant chemotherapy response and genetic susceptibility in recently parous women with breast cancer
Neoadjuvant chemotherapy response and genetic susceptibility in recently parous women with breast cancer Open
Introduction Women with recent parity are at increased short-term breast cancer (BC) risk and face a worse prognosis. The effect of parity on response to neoadjuvant chemotherapy (NAC) is unstudied, and the influence of inherited susceptib…
View article: DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls
DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls Open
Background Epigenetic changes, particularly DNA methylation, are crucial to breast cancer development. Tumor-adjacent normal (AN) tissue frequently serves as a reference for characterizing genomic alterations but is reported to share some …