Sadako Akashi‐Tanaka
YOU?
Author Swipe
View article: Development of an intraoperative margin assessment method for breast cancer using a fluorescence probe targeting α-mannosidase: A multicenter study
Development of an intraoperative margin assessment method for breast cancer using a fluorescence probe targeting α-mannosidase: A multicenter study Open
Background Accurate intraoperative margin assessment is essential to minimize reoperation in breast-conserving surgery (BCS) for breast cancer (BC). This multicenter study aimed to evaluate a novel fluorescent probe targeting α-mannosidase…
View article: Development and internal validation of a predictive model of overall and progression-free survival in eribulin-treated patients with breast cancer based on baseline peripheral blood parameters
Development and internal validation of a predictive model of overall and progression-free survival in eribulin-treated patients with breast cancer based on baseline peripheral blood parameters Open
Background Immune and inflammatory blood parameters have been reported as biomarkers for treatment efficacy. This study aimed to establish a predictive model that includes blood parameters for patients with metastatic breast cancer treated…
View article: Retrospective Analysis of the Clinical Usefulness of a Strut-Adjusted Volume Implant in a Single Center
Retrospective Analysis of the Clinical Usefulness of a Strut-Adjusted Volume Implant in a Single Center Open
The local recurrence rate does not differ between SAVI and WBI within the relatively short-term follow-up period. Longer follow-up is required to confirm our results in the Japanese population.
View article: Severe thrombocytopaenia caused by trastuzumab emtansine in a patient with breast cancer: A case report
Severe thrombocytopaenia caused by trastuzumab emtansine in a patient with breast cancer: A case report Open
We present the case of a 48-year-old woman with human epidermal growth factor receptor 2- and hormone receptor-positive left early breast cancer who developed severe thrombocytopaenia and moderate liver dysfunction after administration of …
View article: Retrospective Analysis of the Clinical Usefulness of a Strut-adjusted Volume Implant in a Single Center
Retrospective Analysis of the Clinical Usefulness of a Strut-adjusted Volume Implant in a Single Center Open
Background: Reports demonstrating the effectiveness and safety of strut-adjusted volume implant (SAVI) in Japan are limited. Therefore, we aimed to compare the treatment outcomes of SAVI and whole breast irradiation (WBI) at a single facil…
View article: Supplementary Table from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Supplementary Table from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study Open
Supplementary Table S1 Association between all CYP2D6 genotype and ER status in pre-treatment tissue.
View article: Data from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Data from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study Open
Purpose: CYP2D6 is the key enzyme responsible for the generation of the potent active metabolite of tamoxifen, “endoxifen.” There are still controversial reports questioning the association between CYP2D6 genotype and tamoxifen efficacy. H…
View article: Supplementary Figures from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Supplementary Figures from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study Open
Supplementary Figure S1. 　ER status in breast cancer tissues was associated with Ki-67 response after tamoxifen therapy. (A) Ki-67 response was lower in the tissues in which the proportion of ER-positive cells was less than 2/3 than in t…
View article: Supplementary Figures from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Supplementary Figures from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study Open
Supplementary Figure S1. 　ER status in breast cancer tissues was associated with Ki-67 response after tamoxifen therapy. (A) Ki-67 response was lower in the tissues in which the proportion of ER-positive cells was less than 2/3 than in t…
View article: Data from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Data from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study Open
Purpose: CYP2D6 is the key enzyme responsible for the generation of the potent active metabolite of tamoxifen, “endoxifen.” There are still controversial reports questioning the association between CYP2D6 genotype and tamoxifen efficacy. H…
View article: Supplementary Table from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Supplementary Table from Significant Effect of Polymorphisms in <i>CYP2D6</i> on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study Open
Supplementary Table S1 Association between all CYP2D6 genotype and ER status in pre-treatment tissue.
View article: Clinical significance of blood endocan level in breast cancer patients
Clinical significance of blood endocan level in breast cancer patients Open
Endocan expression has been associated with aggressive tumor progression and poor outcomes in various cancers. Our preclinical study demonstrated that endocan in the peripheral blood has the potential for use as a prognostic biomarker of t…
View article: A prospective analysis of two studies that used the 5-mm interval slices and 5-mm margin-free method for ipsilateral breast tumor recurrence after breast-conserving surgery without radiotherapy
A prospective analysis of two studies that used the 5-mm interval slices and 5-mm margin-free method for ipsilateral breast tumor recurrence after breast-conserving surgery without radiotherapy Open
Background : Breast-conserving surgery with radiotherapy is one of standard treatments for early breast cancer. However, it is regarded as an option to treat elderly patients with small hormone receptor-positive breast cancer with breast-c…
View article: A comparison of tumor size with ultrasonography and magnetic resonance imaging and histopathology based on ductal carcinoma <i>in situ</i> subtype
A comparison of tumor size with ultrasonography and magnetic resonance imaging and histopathology based on ductal carcinoma <i>in situ</i> subtype Open
The precise measurement and detection of a tumor is indispensable in establishing the regular use of minimally invasive procedures for breast cancer treatment. We, herein, focused on ultrasonography （US） and magnetic resonance imaging （MRI…
View article: Optimal Breast Density Characterization Using a Three-Dimensional Automated Breast Densitometry System
Optimal Breast Density Characterization Using a Three-Dimensional Automated Breast Densitometry System Open
Dense breasts are a risk factor for breast cancer. Assessment of breast density is important and radiologist-dependent. We objectively measured mammographic density using the three-dimensional automatic mammographic density measurement dev…
View article: Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan
Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan Open
Accurate pre-operative localization of nonpalpable lesions plays a pivotal role in guiding breast-conserving surgery (BCS). In this multicenter feasibility study, nonpalpable breast lesions were localized using a handheld magnetic probe (T…
View article: A Case of Arteriovenous Fistula of the Breast as a Complication of Core Needle Biopsy
A Case of Arteriovenous Fistula of the Breast as a Complication of Core Needle Biopsy Open
症例は35歳,女性.健診の乳房超音波検査にて左乳房腫瘤を指摘され,二次精査で針生検を施行,線維腺腫の診断であった.生検時は大きな出血もなく終了.生検翌日より左乳房表在血管の怒張と違和感を認め,前医を受診し同部位にthrillを触知し,定期経過観察としていたが,2年経過した時点で症状増悪認めたため当院を紹介受診となった.CTにて乳房表在に多数の拡張血管と乳房内に多数の動脈からの流入血管を疑う所見を認めた.血管造影検査にて3本以上の流入動脈と2本の流出静脈を認め,左乳房内動静脈…
View article: Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome
Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome Open
Panel sequencing of susceptibility genes for hereditary breast and ovarian cancer (HBOC) syndrome has uncovered numerous germline variants; however, their pathogenic relevance and ethnic diversity remain unclear. Here, we examined the prev…
View article: BRCAness as an Important Prognostic Marker in Patients with Triple-Negative Breast Cancer Treated with Neoadjuvant Chemotherapy: A Multicenter Retrospective Study
BRCAness as an Important Prognostic Marker in Patients with Triple-Negative Breast Cancer Treated with Neoadjuvant Chemotherapy: A Multicenter Retrospective Study Open
Triple-negative breast cancer (TNBC) has several subtypes. The identification of markers associated with recurrence and poor prognosis in patients with TNBC is urgently needed. BRCAness is a set of traits in which BRCA1 dysfunction, arisin…
View article: Datasets and metadata supporting the published article: Prevalence of Disease-Causing Genes in Japanese Patients with BRCA1/2-Wildtype Hereditary Breast and Ovarian Cancer Syndrome
Datasets and metadata supporting the published article: Prevalence of Disease-Causing Genes in Japanese Patients with BRCA1/2-Wildtype Hereditary Breast and Ovarian Cancer Syndrome Open
Panel sequencing of susceptibility genes for hereditary breast and ovarian cancer (HBOC) syndrome has uncovered numerous germline variants; however, their pathogenic relevance and ethnic diversity remain unclear.In this study, the authors …
View article: <i>BRCA1/BRCA2</i> mutations in Japanese women with ductal carcinoma in situ
<i>BRCA1/BRCA2</i> mutations in Japanese women with ductal carcinoma in situ Open
Background Ductal carcinoma in situ (DCIS) is considered a component of the clinical spectrum of breast cancer even in those with BRCA1/2 mutation. The aim of this study was to report the feature of DCIS raised in Japanese women with BRCA1…
View article: Genetic variations in triple-negative breast cancers undergoing neo-adjuvant chemotherapy
Genetic variations in triple-negative breast cancers undergoing neo-adjuvant chemotherapy Open
Aim: Triple negative breast cancer (TNBC) is known as aggressive subtype and have no identified targeted therapies. We examined the relationship of neoadjuvant chemotherapy response to genetic variations of TNBC. Methods: The tumors used i…
View article: QOL Evaluation of Nab-Paclitaxel and Docetaxel for Early Breast Cancer
QOL Evaluation of Nab-Paclitaxel and Docetaxel for Early Breast Cancer Open
There were no significant safety differences between nab-PTX and DTX. HRQoL tended to decrease during taxane-based anticancer treatment, with no significant differences between the treatments. We suggest that the HRQoL questionnaire has li…
View article: A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study
A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study Open
We identified three novel loci, which could be associated with clinical response to tamoxifen. These findings provide new insights into personalized hormonal therapy for the patients with breast cancer.
View article: Satisfaction with Decision Regarding <i>BRCA1/2</i> Genetic Testing and Willingness to Undergo <i>BRCA1/2</i> Genetic Testing in the Future Among Breast Cancer Patients who Had not Previously Undergone <i>BRCA1/2</i> Genetic Testing in Japan
Satisfaction with Decision Regarding <i>BRCA1/2</i> Genetic Testing and Willingness to Undergo <i>BRCA1/2</i> Genetic Testing in the Future Among Breast Cancer Patients who Had not Previously Undergone <i>BRCA1/2</i> Genetic Testing in Japan Open
Breast cancer patients must make their own decision of whether or not to undergo BRCA1/2 genetic testing. The present study investigated satisfaction surrounding this decision and the willingness to undergo BRCA1/2 genetic testing in the f…