S. Altieri
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View article: Characterisation of the neutron beam in the n_TOF-EAR2 experimental area at CERN following the spallation target upgrade
Characterisation of the neutron beam in the n_TOF-EAR2 experimental area at CERN following the spallation target upgrade Open
The n_TOF facility at CERN has undergone a major upgrade after the installation of a new spallation target, designed to improve the performance of both neutron beamlines at the experimental areas 1 and 2 (EAR1 and EAR2) and the commissioni…
View article: The CERN n_TOF NEAR station for astrophysics- and application-related neutron activation measurements
The CERN n_TOF NEAR station for astrophysics- and application-related neutron activation measurements Open
A new experimental area, the NEAR station, has recently been built at the CERN n_TOF facility, at a short distance from the spallation target (3 m). The new area, characterized by a neutron beam of very high flux, has been designed with th…
View article: Capture‐enhanced neutron irradiation to treat Alzheimer's disease: Design of a small animal set‐up for future in‐vivo experiments
Capture‐enhanced neutron irradiation to treat Alzheimer's disease: Design of a small animal set‐up for future in‐vivo experiments Open
Background Alzheimer's disease (AD) is characterized by the accumulation of ‐Amyloid and proteins in the brain that causes dementia. To date, there is no cure capable of eradicating AD, so it is necessary to study a performing therapy. The…
View article: EGFR-targeted antisense oligonucleotides modified with boron clusters offer an innovative approach to cancer chemo-radiotherapy
EGFR-targeted antisense oligonucleotides modified with boron clusters offer an innovative approach to cancer chemo-radiotherapy Open
Suppression of cancer-associated EGFR expression by antisense oligonucleotides is an attractive strategy to augment the efficacy of radiotherapy in cancer treatment. Boron clusters act as selective ligands for the epidermal growth factor r…
View article: New measurement of $^{50}$Cr and $^{53}$Cr (n,$γ$) cross sections at n_TOF: a call for chromium nuclear data revision
New measurement of $^{50}$Cr and $^{53}$Cr (n,$γ$) cross sections at n_TOF: a call for chromium nuclear data revision Open
$^{50}$Cr and $^{53}$Cr are very relevant in criticality safety benchmarks related to nuclear reactors. The discrepancies of up to 30% between the neutron capture cross section evaluations have an important effect on the $k_{eff}$ and $k_{…
View article: Prompt gamma-ray imaging in realistic background conditions of a boron neutron capture therapy facility
Prompt gamma-ray imaging in realistic background conditions of a boron neutron capture therapy facility Open
Boron neutron capture therapy (BNCT) is a highly targeted radiation therapy that shows great promise for treating tumors that are challenging to address with conventional methods. The dose deposited in the tumor during a treatment can be m…
View article: Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes
Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes Open
Melanoma is an aggressive disease that arises from mutations in the cells that produce the pigment melanin, melanocytes. Melanoma is characterized by a high mortality rate, due to avoidance of applied therapies and metastasis to other orga…
View article: Fluorescent Neutron Track Detectors for Boron-10 Microdistribution Measurement in BNCT: A Feasibility Study
Fluorescent Neutron Track Detectors for Boron-10 Microdistribution Measurement in BNCT: A Feasibility Study Open
Boron Neutron-Capture Therapy (BNCT) is a form of radiation therapy that relies on the highly localized and enhanced biological effects of the 10B neutron capture (BNC) reaction products to selectively kill cancer cells. The efficacy of BN…
View article: Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes
Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes Open
Melanoma is an aggressive disease that arises from mutations in the cells that produce the pigment melanin, melanocytes. Melanoma is characterized by a high mortality rate, due to avoidance of applied therapies and metastasis to other orga…
View article: Towards Clinical Integration of a SPECT Detection Module for BNCT Dose Monitoring
Towards Clinical Integration of a SPECT Detection Module for BNCT Dose Monitoring Open
Boron Neutron Capture Therapy (BNCT) is a targeted radiotherapy that requires precise dose monitoring to ensure effective treatment. We initially report experimental measurements performed with the BeNEdiCTE detector, designed for SPECT-ba…
View article: Recent highlights and prospects on (n,<i>γ</i>) measurements at the CERN n_TOF facility
Recent highlights and prospects on (n,<i>γ</i>) measurements at the CERN n_TOF facility Open
Neutron capture cross-section measurements are fundamental in the study of the slow neutron capture (s-) process of nucleosynthesis and for the development of innovative nuclear technologies. One of the best suited methods to measure radia…
View article: Cobaltabis(dicarbollide) [ <i>o</i> -COSAN] <sup>−</sup> loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
Cobaltabis(dicarbollide) [ <i>o</i> -COSAN] <sup>−</sup> loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications Open
Apoferritin-based nanohybrid, Apo:[ o -COSAN] − is designed as a high-capacity boron delivery system for BNCT acting as a multifunctional nanocarrier for targeted cancer therapy, combining high boron payloads with selective tumour cell upt…
View article: Fluorescent Neutron Track Detectors for Boron-10 Micro-Distribution Measurement in BNCT: a Feasibility Study
Fluorescent Neutron Track Detectors for Boron-10 Micro-Distribution Measurement in BNCT: a Feasibility Study Open
The interest in Boron Neutron Capture Therapy (BNCT) has been recently increasing thanks to the latest advancements in accelerator technology which allow to generate the required neutron field from accelerator facilities that could be host…
View article: Towards a new generation of solid total-energy detectors for neutron-capture time-of-flight experiments with intense neutron beams
Towards a new generation of solid total-energy detectors for neutron-capture time-of-flight experiments with intense neutron beams Open
Challenging neutron-capture cross-section measurements of small cross sections and samples with a very limited number of atoms require high-flux time-of-flight facilities. In turn, such facilities need innovative detection setups that are …
View article: Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples
Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples Open
Alzheimer Disease (AD) is the most common cause of dementia. 46.8 million people live with AD worldwide, with numbers projected to almost double every 20 years. The etiological mechanisms underlying the neuropathological changes in AD rema…
View article: Hadron therapy in radiation oncology and why BNCT is a paradigm shift
Hadron therapy in radiation oncology and why BNCT is a paradigm shift Open
Purpose Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in speciali…
View article: Study of the thermal neutron activation of a gamma-ray detector for BNCT dose monitoring
Study of the thermal neutron activation of a gamma-ray detector for BNCT dose monitoring Open
We present a study on the neutron activation of a gamma-ray detector for a BNCT-SPECT dose imaging system. The detector is based on a LaBr 3 (Ce+Sr) scintillator crystal, coupled with a matrix of Silicon Photomultipliers (SiPMs), read by a…
View article: Combining BNCT with carbonic anhydrase inhibition for mesothelioma treatment: Synthesis, in vitro, in vivo studies of ureidosulfamido carboranes
Combining BNCT with carbonic anhydrase inhibition for mesothelioma treatment: Synthesis, in vitro, in vivo studies of ureidosulfamido carboranes Open
Mesothelioma is a malignant neoplasm of mesothelial cells caused by exposure to asbestos. The average survival time after diagnosis is usually nine/twelve months. A multi-therapeutic approach is therefore required to treat and prevent recu…
View article: A compact scintillator-based detector with collimator and shielding for dose monitoring in boron neutron capture therapy
A compact scintillator-based detector with collimator and shielding for dose monitoring in boron neutron capture therapy Open
Boron neutron capture therapy exploits 10B(n,)7Li reactions for targeted tumor destruction. In this work, we aimed at developing a dose monitoring system based on the detection of 478 keV gamma rays emitted by the reactions, which is very …
View article: Description and outlook of the <sup>50,53</sup>Cr(n,γ) cross section measurement at n_TOF and HiSPANoS
Description and outlook of the <sup>50,53</sup>Cr(n,γ) cross section measurement at n_TOF and HiSPANoS Open
Chromium is a very relevant element regarding criticality safety in nuclear reactors because of its presence in stainless steel, an important structural material. Currently, there are serious discrepancies between the different evaluations…
View article: Experimental setup of the <sup>239</sup>Pu neutron capture and fission cross-section measurements at n_TOF, CERN
Experimental setup of the <sup>239</sup>Pu neutron capture and fission cross-section measurements at n_TOF, CERN Open
The experimental setup of the new measurement of 239 Pu fission and capture cross-section in the n_TOF time-of-flight facility at CERN is presented. The measurement aims to address the needs and demands of nuclear data users. The experimen…
View article: Combined BNCT-CIRT treatment planning for glioblastoma using the effect-based optimization
Combined BNCT-CIRT treatment planning for glioblastoma using the effect-based optimization Open
Objective . Boron neutron capture therapy (BNCT) and carbon ion radiotherapy (CIRT) are emerging treatment modalities for glioblastoma. In this study, we investigated the methodology and feasibility to combine BNCT and CIRT treatments. The…