Jens Andersen
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View article: Temporal Dynamics of <scp>tsRNA</scp> Regulation Mark an Abrupt Transition After Epileptogenesis
Temporal Dynamics of <span>tsRNA</span> Regulation Mark an Abrupt Transition After Epileptogenesis Open
Epileptogenesis involves widespread molecular remodeling, including transcriptional and post‐transcriptional changes that reshape neuronal networks. While microRNAs have been extensively studied in this context, the contribution of transfe…
View article: Molecular basis of polyadenylated RNA fate determination in the nucleus
Molecular basis of polyadenylated RNA fate determination in the nucleus Open
Eukaryotic genomes generate a plethora of polyadenylated (pA + ) RNAs 1,2 , that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA + RNPs, including protein-coding RNPs, are exported to…
View article: PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity
PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity Open
Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting replisome components. Here, we find that…
View article: Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling Open
Intraflagellar transport (IFT) is a fundamental process driving ciliogenesis in most eukaryotic organisms. IFT172, the largest protein of the IFT complex, plays a crucial role in cilium formation and is associated with several disease vari…
View article: Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling Open
Intraflagellar transport (IFT) is a fundamental process driving ciliogenesis in most eukaryotic organisms. IFT172, the largest protein of the IFT complex, plays a crucial role in cilium formation and is associated with several disease vari…
View article: Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling Open
Intraflagellar transport (IFT) is a fundamental process driving ciliogenesis in most eukaryotic organisms. IFT172, the largest protein of the IFT complex, plays a crucial role in cilium formation and is associated with several disease vari…
View article: Exploring the structural landscape of DNA maintenance proteins
Exploring the structural landscape of DNA maintenance proteins Open
Evolutionary annotation of genome maintenance (GM) proteins has conventionally been established by remote relationships within protein sequence databases. However, often no significant relationship can be established. Highly sensitive appr…
View article: Dual agonistic and antagonistic roles of ZC3H18 provides for co-activation of distinct nuclear RNA decay pathways
Dual agonistic and antagonistic roles of ZC3H18 provides for co-activation of distinct nuclear RNA decay pathways Open
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the Nuclear EXosome Targeting (NEXT) complex and the PolyA eXosome Targeting (PAXT) connection. Via its association with the…
View article: Supplementary Methods, Figures 1-3, Table 1 from Identification of Let-7–Regulated Oncofetal Genes
Supplementary Methods, Figures 1-3, Table 1 from Identification of Let-7–Regulated Oncofetal Genes Open
Supplementary Methods, Figures 1-3, Table 1 from Identification of Let-7–Regulated Oncofetal Genes
View article: Supplementary Table 2 from Identification of Let-7–Regulated Oncofetal Genes
Supplementary Table 2 from Identification of Let-7–Regulated Oncofetal Genes Open
Supplementary Table 2 from Identification of Let-7–Regulated Oncofetal Genes
View article: Supplementary Methods, Figures 1-3, Table 1 from Identification of Let-7–Regulated Oncofetal Genes
Supplementary Methods, Figures 1-3, Table 1 from Identification of Let-7–Regulated Oncofetal Genes Open
Supplementary Methods, Figures 1-3, Table 1 from Identification of Let-7–Regulated Oncofetal Genes
View article: Data from Identification of Let-7–Regulated Oncofetal Genes
Data from Identification of Let-7–Regulated Oncofetal Genes Open
MicroRNAs (miRNA) are small RNA molecules of ∼20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/m…
View article: Supplementary Table 3 from Identification of Let-7–Regulated Oncofetal Genes
Supplementary Table 3 from Identification of Let-7–Regulated Oncofetal Genes Open
Supplementary Table 3 from Identification of Let-7–Regulated Oncofetal Genes
View article: Supplementary Table 3 from Identification of Let-7–Regulated Oncofetal Genes
Supplementary Table 3 from Identification of Let-7–Regulated Oncofetal Genes Open
Supplementary Table 3 from Identification of Let-7–Regulated Oncofetal Genes
View article: Data from Identification of Let-7–Regulated Oncofetal Genes
Data from Identification of Let-7–Regulated Oncofetal Genes Open
MicroRNAs (miRNA) are small RNA molecules of ∼20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/m…
View article: Supplementary Table 2 from Identification of Let-7–Regulated Oncofetal Genes
Supplementary Table 2 from Identification of Let-7–Regulated Oncofetal Genes Open
Supplementary Table 2 from Identification of Let-7–Regulated Oncofetal Genes
View article: Biochemically validated structural model of the 15-subunit IFT-B complex
Biochemically validated structural model of the 15-subunit IFT-B complex Open
Cilia are ubiquitous eukaryotic organelles important to cellular motility, signalling and sensory reception. Cilium formation requires intraflagellar transport for trafficking of structural and signalling components. The large MDa IFT-B co…
View article: The IFT81-IFT74 complex enhances GTP hydrolysis to inactivate RabL2 during early steps of intraflagellar transport
The IFT81-IFT74 complex enhances GTP hydrolysis to inactivate RabL2 during early steps of intraflagellar transport Open
Cilia are important organelles for signaling and motility and are constructed via intraflagellar transport (IFT). RabL2 is a small Rab-like GTPase that localizes to the basal body of cilia via an interaction with the centriolar protein CEP…
View article: Transient accumulation and bidirectional movement of KIF13B in primary cilia
Transient accumulation and bidirectional movement of KIF13B in primary cilia Open
Primary cilia are microtubule-based sensory organelles whose assembly and function rely on the conserved bidirectional intraflagellar transport (IFT) system, which is powered by anterograde kinesin-2 and retrograde cytoplasmic dynein-2 mot…
View article: Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation
Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation Open
Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is mediated by two adaptors: the Nuclear EXosome Targeting (NEXT) complex and the Poly(A) tail eXosome Targeting (PAXT) connection. Functional analyses of NEX…
View article: CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels Open
CEP78 is a centrosomal protein implicated in ciliogenesis and ciliary length control, and mutations in the CEP78 gene cause retinal cone-rod dystrophy associated with hearing loss. However, the mechanism by which CEP78 affects cilia format…
View article: Transient accumulation and bidirectional movement of KIF13B in primary cilia
Transient accumulation and bidirectional movement of KIF13B in primary cilia Open
Primary cilia are microtubule-based sensory organelles whose assembly and function rely on the conserved bidirectional intraflagellar transport (IFT) system, which is powered by anterograde kinesin-2 and retrograde cytoplasmic dynein 2 mot…