Salvador Arias‐Santiago
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View article: Patients’ Emotional Experiences and Life Changes Following a Diagnosis of Skin Cancer: A Qualitative Study Comparing Melanoma and Squamous Cell Carcinoma
Patients’ Emotional Experiences and Life Changes Following a Diagnosis of Skin Cancer: A Qualitative Study Comparing Melanoma and Squamous Cell Carcinoma Open
Background: Despite advances in diagnosis and treatment, the psychosocial impact of skin cancer remains relatively underexplored. The aim of this study was to explore the emotional experiences of people diagnosed with melanoma and cutaneou…
View article: Update on the Research of an Emulgel for the Effective Treatment of Atopic Dermatitis: Clinical Investigation in Children
Update on the Research of an Emulgel for the Effective Treatment of Atopic Dermatitis: Clinical Investigation in Children Open
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects up to 25% of children and impairs both skin barrier function and quality of life. This study examined the effectiveness of an emulgel containing hyaluronic acid, …
View article: Transitioning from Cyclosporine to Tralokinumab in Moderate-to-Severe Atopic Dermatitis: A Prospective Real-World Comparison of Direct Switch vs. Short Overlap
Transitioning from Cyclosporine to Tralokinumab in Moderate-to-Severe Atopic Dermatitis: A Prospective Real-World Comparison of Direct Switch vs. Short Overlap Open
Background: Cyclosporine (CSA) is a fast-acting systemic immunosuppressant frequently used in moderate-to-severe atopic dermatitis (AD), but its long-term use is limited by toxicity. AD affects as many as 20% of children and nearly 10% of …
View article: Defining a Therapeutic Window of Opportunity in Alopecia Areata: Predictors of Early Response to Baricitinib
Defining a Therapeutic Window of Opportunity in Alopecia Areata: Predictors of Early Response to Baricitinib Open
Background/Objectives: Baricitinib, a selective Janus kinase (JAK) 1 and 2 inhibitor, has recently emerged as a therapeutic option for patients with severe alopecia areata (AA). The aim of this study was to identify clinical and biological…
View article: Impact of Vitiligo on Major Life-changing Decisions and Perceived Stigmatization: A Cross-sectional Study
Impact of Vitiligo on Major Life-changing Decisions and Perceived Stigmatization: A Cross-sectional Study Open
Vitiligo is a chronic autoimmune disease that profoundly affects patients’ quality of life. A cross--sectional, observational study was conducted with 51 patients using self-administered questionnaires, with the aim to evaluate the impact …
View article: Sexual Dysfunction in Melanoma Survivors: A Cross-Sectional Study on Prevalence and Associated Factors
Sexual Dysfunction in Melanoma Survivors: A Cross-Sectional Study on Prevalence and Associated Factors Open
Background/Objectives: Melanoma is a skin cancer that can lead to a poor prognosis. Unlike other oncologic diseases, there is scarce evidence regarding sexual function in melanoma patients, as well as factors associated with sexual dysfunc…
View article: Impact of Hidradenitis Suppurativa on Major Life-Changing Decisions: A Cross-Sectional Study
Impact of Hidradenitis Suppurativa on Major Life-Changing Decisions: A Cross-Sectional Study Open
Hidradenitis suppurativa (HS) significantly impacts patients’ quality of life, particularly in major life-changing decisions (MLCDs) such as career, relationships, and lifestyle. This cross-sectional study involving 50 HS patients identifi…
View article: Effects of Extra Virgin Olive Oil and Petrolatum on Skin Barrier Function and Microtopography
Effects of Extra Virgin Olive Oil and Petrolatum on Skin Barrier Function and Microtopography Open
Background/Objectives: Natural oils are widely promoted and used around the world as part of skincare. Among them, extra virgin olive oil (EVOO) stands out for its broad range of organic compositions and well-known moisturizing properties.…
View article: The Microbiome in Hidradenitis Suppurativa Tunnels: A Systematic Review
The Microbiome in Hidradenitis Suppurativa Tunnels: A Systematic Review Open
Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects the pilosebaceous units, particularly in large skin folds. The pathophysiology of HS is multifactorial, with evidence suggesting that the microbiome plays a cruci…
View article: Application of allogeneic adult mesenchymal stem cells in the treatment of venous ulcers: A phase I/II randomized controlled trial protocol
Application of allogeneic adult mesenchymal stem cells in the treatment of venous ulcers: A phase I/II randomized controlled trial protocol Open
Objective To evaluate the feasibility, safety and efficacy of the cutaneous application of Bioengineered Artificial Mesenchymal Sheet (BAMS) in venous leg ulcers (VLUs) versus conventional treatment. Methods This protocol is based on the d…
View article: Impact on Major Life-changing Decisions in Patients with Atopic Dermatitis
Impact on Major Life-changing Decisions in Patients with Atopic Dermatitis Open
Atopic dermatitis (AD) is a chronic skin disease that significantly affects patients’ quality of life. While other dermatological conditions like psoriasis are known to impact major life-changing decisions (MLCD), no prior studies have eva…
View article: Blood Plasma, Fibrinogen or Fibrin Biomaterial for the Manufacturing of Skin Tissue-Engineered Products and Other Dermatological Treatments: A Systematic Review
Blood Plasma, Fibrinogen or Fibrin Biomaterial for the Manufacturing of Skin Tissue-Engineered Products and Other Dermatological Treatments: A Systematic Review Open
The use of blood plasma, fibrinogen or fibrin, a natural biomaterial, has been widely studied for the development of different skin tissue-engineered products and other dermatological treatments. This systematic review reports the preclini…
View article: Pediatric Kikuchi–Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood
Pediatric Kikuchi–Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood Open
Kikuchi–Fujimoto disease (KFD) is a rare condition characterized by necrotizing lymphadenitis and fever, often associated with immune dysregulation. Histologically, it features necrotic foci with abundant histiocytes and plasmacytoid dendr…
View article: [Translated article] Clinical–Epidemiological Profile, and Treatment Response in Relation to Associated Atopic Comorbidity in Atopic Dermatitis. Experience From the BIOBADATOP Registry
[Translated article] Clinical–Epidemiological Profile, and Treatment Response in Relation to Associated Atopic Comorbidity in Atopic Dermatitis. Experience From the BIOBADATOP Registry Open
Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better underst…
View article: Pediatric Kikuchi-Fujimoto Disease with Malar Erythema: A Case Report and Review of Cutaneous and Histopathologic Presentations in Childhood
Pediatric Kikuchi-Fujimoto Disease with Malar Erythema: A Case Report and Review of Cutaneous and Histopathologic Presentations in Childhood Open
Kikuchi-Fujimoto disease (KFD) is a rare condition characterized by necrotizing lymphadenitis and fever, often associated with immune dysregulation. Histologically, it features necrotic foci with abundant histiocytes and plasmacytoid dendr…
View article: Baricitinib Effectiveness in JAKi‐Naïve and Tofacitinib‐Exposed Patients: A Prospective Study in Alopecia Areata
Baricitinib Effectiveness in JAKi‐Naïve and Tofacitinib‐Exposed Patients: A Prospective Study in Alopecia Areata Open
Background Janus kinase inhibitors (JAKi) have substantially modified the treatment paradigm for alopecia areata (AA). However, the response to switching between these agents following therapeutic failure remains poorly defined. Objective …
View article: Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome
Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome Open
Background Flecainide and other class-Ic antiarrhythmic drugs (AADs) are widely used in Andersen-Tawil syndrome type 1 (ATS1) patients. However, class-Ic drugs might be proarrhythmic in some cases. We investigated the molecular mechanisms …
View article: Microencapsulation, Cream Development, and Controlled Clinical Study of an Upcycled Polyphenolic Extract Combined with sh-Oligopeptide-1
Microencapsulation, Cream Development, and Controlled Clinical Study of an Upcycled Polyphenolic Extract Combined with sh-Oligopeptide-1 Open
Olive mills produce pomace as a by-product of olive oil production process, which has a negative environmental impact. In this study, the dry extract of pomace (OG2), rich in polyphenols, was used for cosmetic purposes. The polyphenolic ex…
View article: Therapeutic burden in hidradenitis suppurativa: a cross‐sectional study of 557 patients
Therapeutic burden in hidradenitis suppurativa: a cross‐sectional study of 557 patients Open
Introduction Therapeutic burden (TB) has been identified as a potential predictor of response to biologic therapy in hidradenitis suppurativa (HS). We aim to analyze the determinants of TB in real‐world clinical settings among HS patients …
View article: Skin Barrier Function and Microtopography in Patients with Atopic Dermatitis
Skin Barrier Function and Microtopography in Patients with Atopic Dermatitis Open
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease whose incidence is increasing. Skin barrier dysfunction plays an important role in this disease. It has been observed that AD patients have higher transepidermal wat…
View article: [Tanslated article] Burnout Syndrome, Anxiety, and Depression in Dermatology Residents: A Cross-Sectional Study
[Tanslated article] Burnout Syndrome, Anxiety, and Depression in Dermatology Residents: A Cross-Sectional Study Open
Burnout syndrome and its comorbidities are both prevalent in dermatology residents in Spain and closely related to each other.
View article: Omalizumab and Dupilumab for the Treatment of Bullous Pemphigoid: A Systematic Review
Omalizumab and Dupilumab for the Treatment of Bullous Pemphigoid: A Systematic Review Open
Background: Bullous pemphigoid (BP) is an autoimmune disease characterized by the appearance of very pruritic subepidermal blisters. It appears mostly in the elderly and is associated with multiple comorbidities, which makes its management…
View article: Antibiotic Nanoparticles-Loaded Wound Dressings Against Pseudomonas aeruginosa’s Skin Infection: A Systematic Review
Antibiotic Nanoparticles-Loaded Wound Dressings Against Pseudomonas aeruginosa’s Skin Infection: A Systematic Review Open
Pseudomonas aeruginosa (P. aeruginosa) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness an…
View article: Generational differences in perceived severity of atopic dermatitis
Generational differences in perceived severity of atopic dermatitis Open
Introduction Atopic dermatitis (AD) is a chronic inflammatory dermatosis that affects all age groups. The impact of AD on patients' lives could differ across generations. Understanding the differences in objective and subjective severity o…
View article: Development of an Emulgel for the Effective Treatment of Atopic Dermatitis: Biocompatibility and Clinical Investigation
Development of an Emulgel for the Effective Treatment of Atopic Dermatitis: Biocompatibility and Clinical Investigation Open
Atopic dermatitis (AD) is a common dermatological disease affecting both children and adults. No drug-free emulgel has been developed and studied in vitro and in vivo for the treatment of AD. The aim of this study was to develop and assess…