Arulselvi Subramanian
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View article: Diagnostic and Prognostic Significance of Serum Biomarkers in Traumatic Spinal Cord Injury: A Prospective Cohort Study
Diagnostic and Prognostic Significance of Serum Biomarkers in Traumatic Spinal Cord Injury: A Prospective Cohort Study Open
Objective: This study was conducted to analyze the association of serum biomarkers (S-100 B protein [S-100β], glial fibrillary acidic protein [GFAP], neuron-specific enolase [NSE], and phosphorylated form of neurofilament protein heavy sub…
View article: Liaison of Dimethylated arginine between PDL1 and its ligand expressions in Gastric Cancer
Liaison of Dimethylated arginine between PDL1 and its ligand expressions in Gastric Cancer Open
Gastric cancer is one of the most common oncological diseases. It can develop in any part of the stomach and spread to other organs, especially in the lungs, liver and oesophagus. Programmed death-1 (PD1), a cell-surface molecule, is invol…
View article: Rapid Thromboelastography Identifies Coagulopathy and Predicts Poor Outcomes in Severe Traumatic Brain Injury
Rapid Thromboelastography Identifies Coagulopathy and Predicts Poor Outcomes in Severe Traumatic Brain Injury Open
Introduction Traumatic brain injury (TBI) occurs when a force transmitted to the head or body results in neuropathologic damage and dysfunction. Approximately 25% of patients with TBI present with coagulopathy on admission, which is associ…
View article: Gut Microbiome Alterations in Patients with Severe Traumatic Brain Injury: A Feasibility Study
Gut Microbiome Alterations in Patients with Severe Traumatic Brain Injury: A Feasibility Study Open
Severe traumatic brain injury (sTBI) is associated with significant morbidity and mortality. Emerging evidence from animal studies suggests a potential role for the gut microbiome in modulating systemic inflammation and neurological outcom…
View article: Role of the Gut-Brain Axis in Severe Traumatic Brain Injury: Insights from Experimental Models and Clinical Studies
Role of the Gut-Brain Axis in Severe Traumatic Brain Injury: Insights from Experimental Models and Clinical Studies Open
Traumatic brain injury (TBI) induces systemic alterations, including gut microbiome dysbiosis, increased intestinal permeability, and neuroinflammatory responses. This review explores the bidirectional gut-brain interactions, focusing on m…
View article: A Comprehensive Review of the Brain–Gut Microbiota System in Traumatic Brain Injury: Mechanisms, Outcomes, and Emerging Interventions
A Comprehensive Review of the Brain–Gut Microbiota System in Traumatic Brain Injury: Mechanisms, Outcomes, and Emerging Interventions Open
Traumatic brain injury (TBI) has profound effects that extend beyond the brain, affecting other body systems via secondary pathways and leading to various complications, including gastrointestinal (GI) dysfunction during and after hospital…
View article: Impact of platelet transfusion on outcome, clot dynamics, and platelet function in thrombocytopenic trauma patients
Impact of platelet transfusion on outcome, clot dynamics, and platelet function in thrombocytopenic trauma patients Open
Objectives: Of all trauma patients, 25% require a blood transfusion, of which 2–3% receive a massive transfusion. In severely injured bleeding trauma patients, early platelet administration has been shown to improve hemostasis and decrease…
View article: Analysing Osteoporosis Detection: A Comparative Study of CNN and FNN
Analysing Osteoporosis Detection: A Comparative Study of CNN and FNN Open
Osteoporosis causes progressive loss of bone density and strength, causing a more elevated risk of fracture than in normal healthy bones. It is estimated that some 1 in 3 women and 1 in 5 men over the age of 50 will experience osteoporotic…
View article: Can laboratory investigations prevent ABO-incompatible-related complications? A rare case report of acute hemolytic transfusion reaction in a poly-trauma patient
Can laboratory investigations prevent ABO-incompatible-related complications? A rare case report of acute hemolytic transfusion reaction in a poly-trauma patient Open
A 15-year-old critically injured male was transferred to the trauma management center after a road traffic accident. The patient had sustained a head injury with a lower limb crush injury and underwent massive blood loss before hospitaliza…
View article: Transfusion Practices in Severely Injured Patients at a Level 1 Trauma Center
Transfusion Practices in Severely Injured Patients at a Level 1 Trauma Center Open
Introduction: Acute trauma resuscitation is challenging and disorganized in low- and middle-income countries as there is lack of evidence-based transfusion practices with respect to ratio, volume, trigger, cutoff points for various trigger…
View article: Impact of Early Microparticle Release during Isolated Severe Traumatic Brain Injury: Correlation with Coagulopathy and Mortality
Impact of Early Microparticle Release during Isolated Severe Traumatic Brain Injury: Correlation with Coagulopathy and Mortality Open
Background: Microparticles (MPs) have been implicated in thrombosis and endothelial dysfunction. Their involvement in early coagulopathy and in worsening of outcomes in isolated severe traumatic brain injury (sTBI) patients remains ill def…
View article: Impact of early and empirical cryoprecipitate administration on the transfusion requirements in trauma patients with hemorrhagic shock
Impact of early and empirical cryoprecipitate administration on the transfusion requirements in trauma patients with hemorrhagic shock Open
BACKGROUND: Fibrinogen is the earliest coagulation factor falling to the critical levels in severely bleeding trauma patients. Early fibrinogen supplementation in these patients has been recommended to improve the patient outcomes. However…
View article: Malarial Antibodies and Endemicity: Does It Affect SARS-CoV-2 Severity and Outcomes?
Malarial Antibodies and Endemicity: Does It Affect SARS-CoV-2 Severity and Outcomes? Open
Background India has a disproportionately lower rate of coronavirus disease 2019 (COVID-19) severe disease and lower death rates with respect to other parts of the world. It has been proposed that malaria-endemic countries such as India ar…
View article: B-217 The study of association of FokI Polymorphism of Vitamin D Receptor (VDR) Gene, Vitamin D and Parathyroid Hormone Levels in Stage 4–5 Chronic Kidney Disease Patients: A Cross-sectional Study
B-217 The study of association of FokI Polymorphism of Vitamin D Receptor (VDR) Gene, Vitamin D and Parathyroid Hormone Levels in Stage 4–5 Chronic Kidney Disease Patients: A Cross-sectional Study Open
Background Chronic Kidney Disease (CKD) is an important public health problem globally and almost 35% patients of CKD have deficiency in vitamin D which progresses to 80% in stage 4–5 CKD patients. Active vitamin D binds to Vitamin D Recep…
View article: Post-mortem detection of a calcifying fibrous pseudotumor at a rare site—A case report
Post-mortem detection of a calcifying fibrous pseudotumor at a rare site—A case report Open
We report the case of a 48 year old man brought-in-dead to the trauma unit following an alleged accidental fall from a multi-storied building. Autopsy findings were consistent with traumatic injuries to the head, chest and spine. Incidenta…
View article: Evaluating platelet concentrates by platelet indices, thromboelastography, and flow cytometry
Evaluating platelet concentrates by platelet indices, thromboelastography, and flow cytometry Open
INTRODUCTION: Platelet transfusion has been therapeutically used in patients with thrombocytopenia and platelet function defects over the years. The use of advanced techniques may add value in assessing the quality of platelet products. Th…
View article: Myelin degradation, axonal changes and expression trajectories of glial cells stimulated by rapid head insult in humans to estimate approximate time elapsed since trauma
Myelin degradation, axonal changes and expression trajectories of glial cells stimulated by rapid head insult in humans to estimate approximate time elapsed since trauma Open
Background Post severe traumatic brain injury (sTBI), axonal alterations lead to myelin loss and its degeneration. In the recovery phase, numerous intermingled biochemical pathways involving complex inflammatory reactions cloud the underst…
View article: Impact of Yoga Intervention in Lower Limb Amputees following Trauma in Relation to Behavior and Quality of Life: A Randomized Controlled Trial
Impact of Yoga Intervention in Lower Limb Amputees following Trauma in Relation to Behavior and Quality of Life: A Randomized Controlled Trial Open
Background: Yoga is an emerging intervention causing improvement in physical, mental, and spiritual well-being. Its role in improving outcomes in patients with amputation was investigated. Methodology: Patients with traumatic lower limb am…
View article: A Combination of Inflammatory and Hematological Markers is Strongly Associated with the Risk of Death in Both Mild and Severe Initial Disease in Unvaccinated Individuals with COVID-19 Infection.
A Combination of Inflammatory and Hematological Markers is Strongly Associated with the Risk of Death in Both Mild and Severe Initial Disease in Unvaccinated Individuals with COVID-19 Infection. Open
The combination of routinely used markers, CRP, IL-6, Ferritin and 1/LCR can be used to predict adverse outcomes, even in those presenting with mild to moderate disease. This would identify subset of patients who would benefit from closer …
View article: Evaluation of plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) as an early diagnostic marker of acute kidney injury (AKI) in critically ill trauma patients
Evaluation of plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) as an early diagnostic marker of acute kidney injury (AKI) in critically ill trauma patients Open
Background and Aims: Acute kidney injury (AKI) is a frequent complication of severe trauma associated with high mortality. The aim of this study was to evaluate the diagnostic ability of plasma and urine neutrophil gelatinase-associated li…
View article: Biocompatible Dressing for Pediatric Hypospadias Repair
Biocompatible Dressing for Pediatric Hypospadias Repair Open
Purpose : The search for an ideal Hypospadias repair dressing continues. We aimed to develop a hypoallergenic optimized biocompatible dressing (BD) Method : BD with a multi-layered structure of hydrophilic treated Polypropylene with three-…
View article: Traumatic Jejunal Mesenteric Pseudocyst in the Vicinity of Blunt Abdominal Trauma with a Brief Review of Literature
Traumatic Jejunal Mesenteric Pseudocyst in the Vicinity of Blunt Abdominal Trauma with a Brief Review of Literature Open
Mesenteric pseudocyst (MP) is a rare heterogeneous group of intra-abdominal benign cystic lesions with different etiopathogenesis and clinically silent behaviours. These lesions are introduced as one of the entities based on the histologic…
View article: Spongiform leukoencephalopathy unveiled in an autopsy of a drug abuser
Spongiform leukoencephalopathy unveiled in an autopsy of a drug abuser Open
Toxic leukoencephalopathy (TLE) is a rare neurological debilitating and fatal condition. It has been previously associated with exposure to leukotoxic offenders such as chemotherapy, cranial radiation, certain drugs, and environmental fact…
View article: Blood component utilization in hospitalized COVID-19 patients: Experience from a dedicated COVID-19 center
Blood component utilization in hospitalized COVID-19 patients: Experience from a dedicated COVID-19 center Open
BACKGROUND: Blood transfusion services were seriously affected during COVID-19 not only due to limited availability of blood components but also due to gap in the clinical knowledge about the need for transfusion in COVID-19 patients. Howe…
View article: Adherence to low volume massive hemorrhage protocol: Experience from an urban level 1 trauma center
Adherence to low volume massive hemorrhage protocol: Experience from an urban level 1 trauma center Open
BACKGROUND AND OBJECTIVES: Adherence to the massive hemorrhage protocol (MHP) is essential for its successful implementation. An indigenous low-volume MHP was designed in accordance with the institutional needs. Adherence to various compon…
View article: A study on the morbid histopathological changes in COVID‐19 patients with or without comorbidities using minimally invasive tissue sampling
A study on the morbid histopathological changes in COVID‐19 patients with or without comorbidities using minimally invasive tissue sampling Open
COVID‐19 causes morbid pathological changes in different organs including lungs, kidneys, liver, and so on, especially in those who succumb. Though clinical outcomes in those with comorbidities are known to be different from those without—…
View article: Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study
Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study Open
Background Calcium has been shown to play a vital role in the pathophysiology of severe acute respiratory syndrome-coronavirus-2 and middle east respiratory syndrome coronavirus diseases, but less is known about hypocalcemia in coronavirus…